U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zbtb3 zinc finger and BTB domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 75291, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Zbtb3provided by MGI
Official Full Name
zinc finger and BTB domain containing 3provided by MGI
Primary source
MGI:MGI:1922541
See related
Ensembl:ENSMUSG00000071661 AllianceGenome:MGI:1922541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930563M09Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in eye; genitourinary system; heart; and limb mesenchyme. Orthologous to human ZBTB3 (zinc finger and BTB domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 14.8), whole brain E14.5 (RPKM 1.6) and 14 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Zbtb3 in Genome Data Viewer
Location:
19 A; 19 5.65 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8779853..8783035)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8802489..8804853)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene interferon induced transmembrane protein 2 pseudogene Neighboring gene TATA-box binding protein associated factor 6 like Neighboring gene STARR-positive B cell enhancer ABC_E2519 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide G Neighboring gene STARR-positive B cell enhancer ABC_E173 Neighboring gene tetratricopeptide repeat domain 9C Neighboring gene STARR-seq mESC enhancer starr_45496 Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 2 Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin Neighboring gene guanine nucleotide binding protein (G protein), gamma 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A natural allele of Nxf1 suppresses retrovirus insertional mutations. Floyd JA, et al. Nat Genet, 2003 Nov. PMID 14517553, Free PMC Article
  2. Identification of differentially expressed genes in mouse spermatogenesis. Pang AL, et al. J Androl, 2003 Nov-Dec. PMID 14581517
  3. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger and BTB domain-containing protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098237.2 → NP_001091707.1  zinc finger and BTB domain-containing protein 3

    See identical proteins and their annotated locations for NP_001091707.1

    Status: VALIDATED

    Source sequence(s)
    AC129217
    Consensus CDS
    CCDS29548.1
    UniProtKB/Swiss-Prot
    Q3UQP3, Q8BIJ4, Q91X45
    Related
    ENSMUSP00000127746.2, ENSMUST00000172175.3
    Conserved Domains (4) summary
    COG5048
    Location:418 → 493
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18323
    Location:1 → 130
    BTB_POZ_ZBTB3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3)
    pfam13465
    Location:433 → 457
    zf-H2C2_2; Zinc-finger double domain

  2. NM_133759.4 → NP_598520.1  zinc finger and BTB domain-containing protein 3

    See identical proteins and their annotated locations for NP_598520.1

    Status: VALIDATED

    Source sequence(s)
    AC129217
    Consensus CDS
    CCDS29548.1
    UniProtKB/Swiss-Prot
    Q3UQP3, Q8BIJ4, Q91X45
    Conserved Domains (4) summary
    COG5048
    Location:418 → 493
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18323
    Location:1 → 130
    BTB_POZ_ZBTB3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3)
    pfam13465
    Location:433 → 457
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8779853..8783035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527420.5 → XP_006527483.1  zinc finger and BTB domain-containing protein 3 isoform X2

    Conserved Domains (1) summary
    cd18323
    Location:1 → 130
    BTB_POZ_ZBTB3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3)

  2. XM_006527419.3 → XP_006527482.1  zinc finger and BTB domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006527482.1

    UniProtKB/Swiss-Prot
    Q3UQP3, Q8BIJ4, Q91X45
    Conserved Domains (4) summary
    COG5048
    Location:418 → 493
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:420 → 440
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18323
    Location:1 → 130
    BTB_POZ_ZBTB3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3)
    pfam13465
    Location:433 → 457
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91X45.3 GenPept UniProtKB/Swiss-Prot:Q91X45

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous