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Ankrd7 ankyrin repeat domain 7 [ Mus musculus (house mouse) ]

Gene ID: 75196, updated on 21-Apr-2024

Summary

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Official Symbol
Ankrd7provided by MGI
Official Full Name
ankyrin repeat domain 7provided by MGI
Primary source
MGI:MGI:1922446
See related
Ensembl:ENSMUSG00000029517 AllianceGenome:MGI:1922446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930532L20Rik
Summary
Acts upstream of or within blastocyst hatching. Located in nucleus. Is expressed in early conceptus. Orthologous to human ANKRD7 (ankyrin repeat domain 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.7), cerebellum adult (RPKM 0.3) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A2; 6 8.16 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (18855830..18879588)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (18855842..18879589)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:18798382-18798683 Neighboring gene STARR-seq mESC enhancer starr_15273 Neighboring gene predicted gene 5874 Neighboring gene LSM8 homolog, U6 small nuclear RNA associated Neighboring gene STARR-seq mESC enhancer starr_15274 Neighboring gene STARR-seq mESC enhancer starr_15275 Neighboring gene STARR-seq mESC enhancer starr_15276 Neighboring gene protein disulfide isomerase associated 6 pseudogene Neighboring gene STARR-seq mESC enhancer starr_15277 Neighboring gene RIKEN cDNA 4930524B17 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ankrd7, a novel gene specifically expressed in Sertoli cells and its potential roles in Sertoli cell maturation. Shi YQ, et al. Mol Cells, 2009 Feb 28. PMID 19277502
  2. CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†. Lu Y, et al. Biol Reprod, 2019 Aug 1. PMID 31201419, Free PMC Article
  3. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  4. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167757.1 → NP_001161229.1  ankyrin repeat domain-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001161229.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC167438, AK077080, BB019296
    Consensus CDS
    CCDS51724.1
    UniProtKB/TrEMBL
    A0A0R4J1L1
    Related
    ENSMUSP00000111054.3, ENSMUST00000115396.7
    Conserved Domains (4) summary
    cd00204
    Location:75 → 201
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:121 → 211
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:200 → 254
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:113 → 145
    ANK; ANK repeat [structural motif]

  2. NM_029202.2 → NP_083478.2  ankyrin repeat domain-containing protein 7 isoform 2

    See identical proteins and their annotated locations for NP_083478.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is one aa shorter compared to isoform 1.
    Source sequence(s)
    AC167438, AK015948, AK077080, BB019296
    Consensus CDS
    CCDS19933.1
    UniProtKB/Swiss-Prot
    Q810N2, Q8BVP4, Q9D504
    Related
    ENSMUSP00000031489.7, ENSMUST00000031489.10
    Conserved Domains (4) summary
    cd00204
    Location:75 → 200
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:118 → 210
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:199 → 253
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:113 → 144
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    18855830..18879588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505191.5 → XP_006505254.1  ankyrin repeat domain-containing protein 7 isoform X1

    Conserved Domains (2) summary
    sd00045
    Location:56 → 88
    ANK; ANK repeat [structural motif]
    cl39094
    Location:25 → 178
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_006505192.3 → XP_006505255.1  ankyrin repeat domain-containing protein 7 isoform X2

    Conserved Domains (2) summary
    sd00045
    Location:113 → 145
    ANK; ANK repeat [structural motif]
    cl39094
    Location:51 → 213
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. XR_003956259.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D504.2 GenPept UniProtKB/Swiss-Prot:Q9D504

Gene LinkOut

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