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Mmd2 monocyte to macrophage differentiation-associated 2 [ Mus musculus (house mouse) ]

Gene ID: 75104, updated on 5-Mar-2024

Summary

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Official Symbol
Mmd2provided by MGI
Official Full Name
monocyte to macrophage differentiation-associated 2provided by MGI
Primary source
MGI:MGI:1922354
See related
Ensembl:ENSMUSG00000039533 AllianceGenome:MGI:1922354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930518M15Rik
Summary
Predicted to enable protein kinase activity. Predicted to be involved in several processes, including positive regulation of Ras protein signal transduction; positive regulation of neuron differentiation; and positive regulation of protein kinase activity. Predicted to be located in perinuclear region of cytoplasm. Is expressed in central nervous system; gonad; liver; and peripheral nervous system ganglion. Orthologous to human MMD2 (monocyte to macrophage differentiation associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 31.8), cortex adult (RPKM 26.0) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Mmd2 in Genome Data Viewer
Location:
5 G2; 5 81.53 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142549229..142594886, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142563480..142608936, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Ras association and DIL domains Neighboring gene predicted gene, 38732 Neighboring gene poly (A) polymerase beta (testis specific) Neighboring gene STARR-positive B cell enhancer ABC_E8090 Neighboring gene STARR-positive B cell enhancer ABC_E10363 Neighboring gene predicted gene, 31274 Neighboring gene WD repeat domain, phosphoinositide interacting 2 Neighboring gene STARR-seq mESC enhancer starr_14752

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice. Zhao L, et al. Sex Dev, 2022. PMID 35306493
  2. Pancreatic expression and mitochondrial localization of the progestin-adipoQ receptor PAQR10. Góñez LJ, et al. Mol Med, 2008 Nov-Dec. PMID 18769639, Free PMC Article
  3. Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Kang P, et al. Neuron, 2012 Apr 12. PMID 22500632, Free PMC Article
  4. Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons. Machado CB, et al. Development, 2014 Feb. PMID 24496616, Free PMC Article
  5. Floor plate-derived sonic hedgehog regulates glial and ependymal cell fates in the developing spinal cord. Yu K, et al. Development, 2013 Apr. PMID 23482494, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables pore-forming activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
monocyte to macrophage differentiation factor 2
Names
progestin and adipoQ receptor family member 10
progestin and adipoQ receptor family member X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417873.1 → NP_001404802.1  monocyte to macrophage differentiation factor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158310

  2. NM_001417874.1 → NP_001404803.1  monocyte to macrophage differentiation factor 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158310

  3. NM_175217.7 → NP_780426.1  monocyte to macrophage differentiation factor 2 isoform 1

    See identical proteins and their annotated locations for NP_780426.1

    Status: VALIDATED

    Source sequence(s)
    AC158310
    Consensus CDS
    CCDS39363.1
    UniProtKB/Swiss-Prot
    Q8R189
    UniProtKB/TrEMBL
    Q3V1Z9
    Related
    ENSMUSP00000039357.8, ENSMUST00000037048.9
    Conserved Domains (1) summary
    cl03831
    Location:35 → 235
    HlyIII; Haemolysin-III related

RNA

  1. NR_184650.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158310

  2. NR_184651.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158310

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    142549229..142594886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165572.1 → XP_036021465.1  monocyte to macrophage differentiation factor 2 isoform X2

  2. XM_011240988.4 → XP_011239290.1  monocyte to macrophage differentiation factor 2 isoform X1

    Conserved Domains (1) summary
    cl03831
    Location:17 → 217
    HlyIII; Haemolysin-III related
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R189.1 GenPept UniProtKB/Swiss-Prot:Q8R189

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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