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Sf3a3 splicing factor 3a, subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 75062, updated on 11-Apr-2024

Summary

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Official Symbol
Sf3a3provided by MGI
Official Full Name
splicing factor 3a, subunit 3provided by MGI
Primary source
MGI:MGI:1922312
See related
Ensembl:ENSMUSG00000028902 AllianceGenome:MGI:1922312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
60kDa; 4930512K19Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in U2-type prespliceosome assembly. Predicted to act upstream of or within RNA splicing. Part of U2 snRNP. Is expressed in central nervous system and sensory organ. Orthologous to human SF3A3 (splicing factor 3a subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 56.6), liver E14 (RPKM 31.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Sf3a3 in Genome Data Viewer
Location:
4 D2.2; 4 57.88 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124602966..124626234)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124714861..124732423)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene UTP11 small subunit processome component Neighboring gene STARR-positive B cell enhancer ABC_E6213 Neighboring gene STARR-seq mESC enhancer starr_11340 Neighboring gene four and a half LIM domains 3 Neighboring gene STARR-positive B cell enhancer ABC_E6214 Neighboring gene PRELI domain containing 1 pseudogene Neighboring gene microRNA 697 Neighboring gene predicted gene 12915 Neighboring gene predicted gene, 32117 Neighboring gene inositol polyphosphate-5-phosphatase B Neighboring gene microRNA 698

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Temporal and tissue specific regulation of RP-associated splicing factor genes PRPF3, PRPF31 and PRPC8--implications in the pathogenesis of RP. Cao H, et al. PLoS One, 2011 Jan 19. PMID 21283520, Free PMC Article
  2. STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells. Jin L, et al. Nat Commun, 2020 Nov 23. PMID 33230114, Free PMC Article
  3. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
  4. Oct4 links multiple epigenetic pathways to the pluripotency network. Ding J, et al. Cell Res, 2012 Jan. PMID 22083510, Free PMC Article
  5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103282

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in U2-type prespliceosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U2 snRNP ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
splicing factor 3A subunit 3
Names
SAP 61
SF3a60
spliceosome-associated protein 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029157.4 → NP_083433.1  splicing factor 3A subunit 3

    See identical proteins and their annotated locations for NP_083433.1

    Status: VALIDATED

    Source sequence(s)
    AL606907
    Consensus CDS
    CCDS38875.1
    UniProtKB/Swiss-Prot
    Q9D554
    UniProtKB/TrEMBL
    Q58E59
    Related
    ENSMUSP00000030734.5, ENSMUST00000030734.5
    Conserved Domains (2) summary
    COG5188
    Location:2 → 501
    PRP9; Splicing factor 3a, subunit 3 [RNA processing and modification]
    pfam11931
    Location:323 → 500
    DUF3449; Domain of unknown function (DUF3449)

RNA

  1. NR_185053.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL606907

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    124602966..124626234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164510.1 → XP_036020403.1  splicing factor 3A subunit 3 isoform X1

    UniProtKB/Swiss-Prot
    Q9D554
    UniProtKB/TrEMBL
    Q58E59
    Conserved Domains (2) summary
    COG5188
    Location:2 → 501
    PRP9; Splicing factor 3a, subunit 3 [RNA processing and modification]
    pfam11931
    Location:323 → 500
    DUF3449; Domain of unknown function (DUF3449)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D554.2 GenPept UniProtKB/Swiss-Prot:Q9D554

Gene LinkOut

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