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GAS8-AS1 GAS8 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 750, updated on 10-Oct-2023

Summary

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Official Symbol
GAS8-AS1provided by HGNC
Official Full Name
GAS8 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:1197
See related
Ensembl:ENSG00000221819 MIM:605179; AllianceGenome:HGNC:1197
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C16orf3
Summary
This gene encodes a long non-coding RNA (lncRNA) that may function as a tumor suppressor. Mutations in this gene have been identified in human papillary thyroid carcinoma (PTC) patients that abrogate the ability of encoded lncRNA to inhibit cancer cell growth. [provided by RefSeq, May 2017]
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Genomic context

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See GAS8-AS1 in Genome Data Viewer
Location:
16q24.3
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (90028908..90029901, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (96115103..96116120, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (90095316..90096309, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:90039036-90040019 Neighboring gene AFG3 like matrix AAA peptidase subunit 1, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr16:90054784-90054958 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:90059900-90060881 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:90061681-90062880 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46884 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46891 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:90066749-90066899 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_46902 Neighboring gene dysbindin domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7936 Neighboring gene Sharpr-MPRA regulatory region 21 Neighboring gene growth arrest specific 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:90112831-90113344 Neighboring gene urate (hydroxyiso-) hydrolase, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:90123853-90125052 Neighboring gene PR/SET domain 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7937

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LncRNA GAS8-AS1 is a Novel Prognostic and Diagnostic Biomarker for Pancreatic Cancer. Li Z, et al. Crit Rev Eukaryot Gene Expr, 2022. PMID 35695668
  2. Long noncoding RNA GAS8-AS1: A novel biomarker in human diseases. Li G, et al. Biomed Pharmacother, 2021 Jul. PMID 33838502
  3. lncRNA GAS8-AS1 genetic alterations in papillary thyroid carcinoma and their clinical significance. Zhou DL, et al. Cancer Biomark, 2020. PMID 32675393
  4. Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients. Zhang D, et al. Int J Endocrinol, 2017. PMID 28781594, Free PMC Article
  5. Expression analysis of growth arrest specific 8 and its anti-sense in breast cancer tissues. Dashti S, et al. Exp Mol Pathol, 2020 Jun. PMID 32165089

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA GAS8-AS1 is a Novel Prognostic and Diagnostic Biomarker for Pancreatic Cancer.
    Title: LncRNA GAS8-AS1 is a Novel Prognostic and Diagnostic Biomarker for Pancreatic Cancer.
  2. Long noncoding RNA GAS8-AS1: A novel biomarker in human diseases.
    Title: Long noncoding RNA GAS8-AS1: A novel biomarker in human diseases.
  3. lncRNA GAS8-AS1 genetic alterations in papillary thyroid carcinoma and their clinical significance.
    Title: lncRNA GAS8-AS1 genetic alterations in papillary thyroid carcinoma and their clinical significance.
  4. lncRNA GAS8-AS1 downregulates lncRNA UCA1 to inhibit osteosarcoma cell migration and invasion.
    Title: lncRNA GAS8-AS1 downregulates lncRNA UCA1 to inhibit osteosarcoma cell migration and invasion.
  5. Expression analysis of growth arrest specific 8 and its anti-sense in breast cancer tissues.
    Title: Expression analysis of growth arrest specific 8 and its anti-sense in breast cancer tissues.
  6. The current study shows significance of GAS8 and GAS8-AS1 in the pathogenesis of MS and the putative role of GAS8-AS1 as a diagnostic biomarker in a subset of patients.
    Title: GAS8 and its naturally occurring antisense RNA as biomarkers in multiple sclerosis.
  7. LncRNA GAS8-AS1 suppresses papillary thyroid carcinoma cell growth through the miR-135b-5p/CCND2 axis.
    Title: LncRNA GAS8-AS1 suppresses papillary thyroid carcinoma cell growth through the miR-135b-5p/CCND2 axis.
  8. GAS8-AS1 was downregulated in colorectal cancer (CRC), and its overexpression may inhibit the proliferation of CRC cells by downregulating oncogenic lncRNA AFAP1-AS1.
    Title: LncRNA GAS8-AS inhibits colorectal cancer (CRC) cell proliferation by downregulating lncRNA AFAP1-AS1.
  9. Expression of GAS8-AS1 or GAS8 is significantly decreased in hepatocellular carcinoma tissues and is associated with a poor prognosis among hepatocellular carcinoma patients.
    Title: The long noncoding RNA GAS8-AS1 suppresses hepatocarcinogenesis by epigenetically activating the tumor suppressor GAS8.
  10. Mutation in GAS8-AS1 gene is associated with papillary thyroid carcinoma.
    Title: Whole exome sequencing identifies lncRNA GAS8-AS1 and LPAR4 as novel papillary thyroid carcinoma driver alternations.
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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • uncharacterized protein C16orf3

Clone Names

  • MGC132509

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054714.1 RefSeqGene

    Range
    5001..5994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_122031.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC133919, AF050081
    Related
    ENST00000408886.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    90028908..90029901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    96115103..96116120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001214.3: Suppressed sequence

    Description
    NM_001214.3: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version

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