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Rab11fip2 RAB11 family interacting protein 2 (class I) [ Mus musculus (house mouse) ]

Gene ID: 74998, updated on 5-Mar-2024

Summary

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Official Symbol
Rab11fip2provided by MGI
Official Full Name
RAB11 family interacting protein 2 (class I)provided by MGI
Primary source
MGI:MGI:1922248
See related
Ensembl:ENSMUSG00000040022 AllianceGenome:MGI:1922248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nrip11; 4930470G04Rik; A830046J09Rik
Summary
Predicted to enable protein homodimerization activity and protein kinase binding activity. Involved in insulin secretion involved in cellular response to glucose stimulus and regulated exocytosis. Predicted to be located in nucleoplasm. Predicted to be active in endosome and phagocytic cup. Is expressed in nephric duct of male and telencephalon ventricular layer. Orthologous to human RAB11FIP2 (RAB11 family interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 5.3), CNS E18 (RPKM 5.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 D3; 19 56.28 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (59881934..59933086, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (59893502..59943656, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46662 Neighboring gene predicted gene, 46660 Neighboring gene STARR-seq mESC enhancer starr_46593 Neighboring gene VISTA enhancer mm449 Neighboring gene predicted gene, 41879 Neighboring gene predicted gene, 41880

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab11FIP1-deficient mice develop spontaneous inflammation and show increased susceptibility to colon damage. Rathan-Kumar S, et al. Am J Physiol Gastrointest Liver Physiol, 2022 Sep 1. PMID 35819177, Free PMC Article
  2. Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking. Matthies HJ, et al. J Neurosci, 2010 Jun 9. PMID 20534835, Free PMC Article
  3. Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity. Wang Z, et al. Cell, 2008 Oct 31. PMID 18984164, Free PMC Article
  4. Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis. Sugawara K, et al. Genes Cells, 2009 Apr. PMID 19335615
  5. Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors. Cullis DN, et al. J Biol Chem, 2002 Dec 20. PMID 12364336

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data demonstrate that AMPH leads to an increase of NET in endosomes of single boutons and varicosities in a Rab11-dependent manner.
    Title: Rab11 supports amphetamine-stimulated norepinephrine transporter trafficking.
  2. Rab11-FIP2 has a role in the coupling of receptor-mediated endocytosis to the subsequent sorting of receptor-containing vesicles in endosomes [RAB11-FIP2]
    Title: Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in TRAM-dependent toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phagocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulated exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in phagocytic cup IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic cup ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rab11 family-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033172.3 → NP_001028344.2  rab11 family-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001028344.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC105061, AC162855, BC089010
    Consensus CDS
    CCDS38033.1
    UniProtKB/TrEMBL
    Q3U366
    Related
    ENSMUSP00000059978.7, ENSMUST00000051996.13
    Conserved Domains (2) summary
    cd08682
    Location:15 → 141
    C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
    pfam09457
    Location:452 → 499
    RBD-FIP; FIP domain

  2. NM_001164367.1 → NP_001157839.1  rab11 family-interacting protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001157839.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also contains an alternate segment in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC105061, AC162855, AK015534, BC089010
    Consensus CDS
    CCDS50482.1
    UniProtKB/TrEMBL
    G3UW57
    Related
    ENSMUSP00000128813.2, ENSMUST00000171986.8
    Conserved Domains (1) summary
    pfam09457
    Location:310 → 357
    RBD-FIP; FIP domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    59881934..59933086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247386.4 → XP_011245688.1  rab11 family-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    B9EID4, G3XA57, Q5HZI0
    Conserved Domains (2) summary
    cd08682
    Location:15 → 141
    C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
    pfam09457
    Location:452 → 499
    RBD-FIP; FIP domain

  2. XM_036161718.1 → XP_036017611.1  rab11 family-interacting protein 2 isoform X2

    Conserved Domains (2) summary
    pfam09457
    Location:348 → 395
    RBD-FIP; FIP domain
    cl14603
    Location:14 → 37
    C2; C2 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3XA57.1 GenPept UniProtKB/Swiss-Prot:G3XA57

Gene LinkOut

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