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Slc35f6 solute carrier family 35, member F6 [ Mus musculus (house mouse) ]

Gene ID: 74919, updated on 11-Apr-2024

Summary

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Official Symbol
Slc35f6provided by MGI
Official Full Name
solute carrier family 35, member F6provided by MGI
Primary source
MGI:MGI:1922169
See related
Ensembl:ENSMUSG00000029175 AllianceGenome:MGI:1922169
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P40; ANT2BP; Tango9; 4930471M23Rik; 5730478O19Rik
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway and positive regulation of cell population proliferation. Located in lysosome. Orthologous to human SLC35F6 (solute carrier family 35 member F6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 21.2), adrenal adult (RPKM 19.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc35f6 in Genome Data Viewer
Location:
5 B1; 5 16.74 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30805272..30817073)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30647939..30659729)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene calcium and integrin binding family member 4 Neighboring gene predicted gene, 40272 Neighboring gene predicted gene 9899 Neighboring gene potassium channel, subfamily K, member 3 Neighboring gene STARR-seq mESC enhancer starr_12757 Neighboring gene STARR-seq mESC enhancer starr_12759 Neighboring gene microRNA 5625 Neighboring gene STARR-positive B cell enhancer ABC_E4748 Neighboring gene centromere protein A Neighboring gene predicted gene, 57741

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Intracellular localization of p40, a protein identified in a preparation of lysosomal membranes. Boonen M, et al. Biochem J, 2006 Apr 1. PMID 16367739, Free PMC Article
  2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 35 member F6
Names
ANT2-binding protein
transmembrane protein C2orf18 homolog
transport and Golgi organization 9 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175675.3 → NP_783606.2  solute carrier family 35 member F6 precursor

    See identical proteins and their annotated locations for NP_783606.2

    Status: VALIDATED

    Source sequence(s)
    AK049408, AK051359, BY166812
    Consensus CDS
    CCDS19161.1
    UniProtKB/Swiss-Prot
    Q3UB33, Q8BKN1, Q8VE96, Q9D5B2
    UniProtKB/TrEMBL
    Q8BK02
    Related
    ENSMUSP00000058680.6, ENSMUST00000062962.12
    Conserved Domains (1) summary
    cl23754
    Location:105 → 160
    EamA; EamA-like transporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    30805272..30817073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165569.1 → XP_036021462.1  solute carrier family 35 member F6 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JEG3
    Related
    ENSMUSP00000142761.2, ENSMUST00000196740.5
    Conserved Domains (1) summary
    pfam04142
    Location:31 → 105
    Nuc_sug_transp; Nucleotide-sugar transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VE96.1 GenPept UniProtKB/Swiss-Prot:Q8VE96

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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