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Kbtbd11 kelch repeat and BTB (POZ) domain containing 11 [ Mus musculus (house mouse) ]

Gene ID: 74901, updated on 5-Mar-2024

Summary

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Official Symbol
Kbtbd11provided by MGI
Official Full Name
kelch repeat and BTB (POZ) domain containing 11provided by MGI
Primary source
MGI:MGI:1922151
See related
Ensembl:ENSMUSG00000055675 AllianceGenome:MGI:1922151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0711; 2900016B01Rik; 4930465M17Rik
Summary
Is expressed in several structures, including central nervous system; early tubule; ganglia; lung; and sensory organ. Orthologous to human KBTBD11 (kelch repeat and BTB domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 21.9), mammary gland adult (RPKM 18.9) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A1.1; 8 7.59 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (15059408..15083333)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (15011025..15033333)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 10 Neighboring gene STARR-positive B cell enhancer mm9_chr8:14961480-14961780 Neighboring gene predicted gene 16350 Neighboring gene STARR-positive B cell enhancer ABC_E4990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:14996167-14996320 Neighboring gene predicted gene, 35149 Neighboring gene STARR-seq mESC enhancer starr_20800 Neighboring gene predicted gene, 35340 Neighboring gene expressed sequence BB014433

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Kbtbd11 gene expression in adipose tissue increases in response to feeding and affects adipocyte differentiation. Watanabe K, et al. J Diabetes Investig, 2019 Jul. PMID 30582777, Free PMC Article
  2. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
  3. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
  4. Gene expression analysis of the embryonic subplate. Oeschger FM, et al. Cereb Cortex, 2012 Jun. PMID 21862448, Free PMC Article
  5. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kbtbd11 appears to be required for the differentiation of adipocytes in 3T3-L1 cells
    Title: Kbtbd11 gene expression in adipose tissue increases in response to feeding and affects adipocyte differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
kelch repeat and BTB domain-containing protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029116.2 → NP_083392.1  kelch repeat and BTB domain-containing protein 11

    See identical proteins and their annotated locations for NP_083392.1

    Status: VALIDATED

    Source sequence(s)
    AC124604, AK013531, BC080858, BY712628, CX207757
    Consensus CDS
    CCDS52493.1
    UniProtKB/Swiss-Prot
    A3KME3, Q8BNW9
    Related
    ENSMUSP00000068321.6, ENSMUST00000069399.7
    Conserved Domains (5) summary
    PHA03098
    Location:354 → 491
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:356 → 404
    Kelch; KELCH repeat [structural motif]
    cl38908
    Location:142 → 246
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    NF033913
    Location:16 → 108
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl28903
    Location:237 → 313
    BACK; BACK (BTB and C-terminal Kelch) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    15059408..15083333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508915.3 → XP_006508978.1  kelch repeat and BTB domain-containing protein 11 isoform X1

    See identical proteins and their annotated locations for XP_006508978.1

    UniProtKB/Swiss-Prot
    A3KME3, Q8BNW9
    Conserved Domains (5) summary
    PHA03098
    Location:354 → 491
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:356 → 404
    Kelch; KELCH repeat [structural motif]
    cl38908
    Location:142 → 246
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    NF033913
    Location:16 → 108
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl28903
    Location:237 → 313
    BACK; BACK (BTB and C-terminal Kelch) domain

  2. XM_006508916.4 → XP_006508979.1  kelch repeat and BTB domain-containing protein 11 isoform X1

    See identical proteins and their annotated locations for XP_006508979.1

    UniProtKB/Swiss-Prot
    A3KME3, Q8BNW9
    Conserved Domains (5) summary
    PHA03098
    Location:354 → 491
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:356 → 404
    Kelch; KELCH repeat [structural motif]
    cl38908
    Location:142 → 246
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    NF033913
    Location:16 → 108
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl28903
    Location:237 → 313
    BACK; BACK (BTB and C-terminal Kelch) domain

  3. XM_036154344.1 → XP_036010237.1  kelch repeat and BTB domain-containing protein 11 isoform X1

    UniProtKB/Swiss-Prot
    A3KME3, Q8BNW9
    Related
    ENSMUSP00000139292.2, ENSMUST00000183471.2
    Conserved Domains (5) summary
    PHA03098
    Location:354 → 491
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:356 → 404
    Kelch; KELCH repeat [structural motif]
    cl38908
    Location:142 → 246
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    NF033913
    Location:16 → 108
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl28903
    Location:237 → 313
    BACK; BACK (BTB and C-terminal Kelch) domain

  4. XM_036154345.1 → XP_036010238.1  kelch repeat and BTB domain-containing protein 11 isoform X1

    UniProtKB/Swiss-Prot
    A3KME3, Q8BNW9
    Conserved Domains (5) summary
    PHA03098
    Location:354 → 491
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:356 → 404
    Kelch; KELCH repeat [structural motif]
    cl38908
    Location:142 → 246
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    NF033913
    Location:16 → 108
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl28903
    Location:237 → 313
    BACK; BACK (BTB and C-terminal Kelch) domain

RNA

  1. XR_870083.3 RNA Sequence

  2. XR_870084.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BNW9.3 GenPept UniProtKB/Swiss-Prot:Q8BNW9

Gene LinkOut

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