U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hhatl hedgehog acyltransferase-like [ Mus musculus (house mouse) ]

Gene ID: 74770, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Hhatlprovided by MGI
Official Full Name
hedgehog acyltransferase-likeprovided by MGI
Primary source
MGI:MGI:1922020
See related
Ensembl:ENSMUSG00000032523 AllianceGenome:MGI:1922020
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gup1; Mg56; 1110011D13Rik
Summary
Predicted to enable acyltransferase activity. Involved in negative regulation of N-terminal protein palmitoylation. Located in endoplasmic reticulum. Orthologous to human HHATL (hedgehog acyltransferase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 20.6), mammary gland adult (RPKM 4.7) and 6 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 F4; 9 72.62 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121613082..121626604, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121784016..121792507, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E530011L22 gene Neighboring gene STARR-positive B cell enhancer ABC_E6812 Neighboring gene zinc finger and BTB domain containing 47 Neighboring gene kelch-like 40 Neighboring gene coiled-coil domain containing 13 Neighboring gene predicted gene, 51698 Neighboring gene STARR-positive B cell enhancer ABC_E3869 Neighboring gene HIG1 domain family, member 1A Neighboring gene predicted gene, 47112

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation. Van B, et al. FEBS Lett, 2015 Apr 28. PMID 25841338
  2. Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog. Abe Y, et al. FEBS J, 2008 Jan. PMID 18081866
  3. Isolation of novel heart-specific genes using the BodyMap database. Soejima H, et al. Genomics, 2001 May 15. PMID 11374908
  4. Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Richard AF, et al. Dev Biol, 2011 Nov 15. PMID 21884692
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MG56 seems essential for postnatal skeletal muscle maturation
    Title: Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation.
  2. results suggest that Gup1 is a negative regulator of N-terminal palmitoylation of Shh and may contribute to the variety of biological actions of Shh
    Title: Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of N-terminal protein palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of N-terminal protein palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein-cysteine N-palmitoyltransferase HHAT-like protein
Names
Mitsugumin 56
glycerol uptake/transporter homolog
hedgehog acyltransferase-like protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029095.2 → NP_083371.2  protein-cysteine N-palmitoyltransferase HHAT-like protein

    See identical proteins and their annotated locations for NP_083371.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AC165080, AK003605, BY232310, BY290483, BY703867
    Consensus CDS
    CCDS23638.1
    UniProtKB/Swiss-Prot
    Q3TZE3, Q8R1K3, Q9D1G3
    Related
    ENSMUSP00000035110.5, ENSMUST00000035110.11
    Conserved Domains (1) summary
    cl00738
    Location:139 → 449
    MBOAT; membrane-bound O-acyltransferase family

RNA

  1. NR_027967.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC165080, AK157924

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    121613082..121626604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155362.1 → XP_036011255.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X2

    Conserved Domains (1) summary
    cl00738
    Location:86 → 235
    MBOAT; membrane-bound O-acyltransferase family

  2. XM_030244689.2 → XP_030100549.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X1

    UniProtKB/Swiss-Prot
    Q3TZE3, Q8R1K3, Q9D1G3
    Conserved Domains (1) summary
    cl00738
    Location:139 → 449
    MBOAT; membrane-bound O-acyltransferase family

  3. XM_006512380.5 → XP_006512443.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X1

    See identical proteins and their annotated locations for XP_006512443.1

    UniProtKB/Swiss-Prot
    Q3TZE3, Q8R1K3, Q9D1G3
    Conserved Domains (1) summary
    cl00738
    Location:139 → 449
    MBOAT; membrane-bound O-acyltransferase family

  4. XM_006512379.4 → XP_006512442.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X1

    See identical proteins and their annotated locations for XP_006512442.1

    UniProtKB/Swiss-Prot
    Q3TZE3, Q8R1K3, Q9D1G3
    Conserved Domains (1) summary
    cl00738
    Location:139 → 449
    MBOAT; membrane-bound O-acyltransferase family

  5. XM_006512381.4 → XP_006512444.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X1

    See identical proteins and their annotated locations for XP_006512444.1

    UniProtKB/Swiss-Prot
    Q3TZE3, Q8R1K3, Q9D1G3
    Related
    ENSMUSP00000131971.2, ENSMUST00000163981.3
    Conserved Domains (1) summary
    cl00738
    Location:139 → 449
    MBOAT; membrane-bound O-acyltransferase family

  6. XM_011243053.2 → XP_011241355.1  protein-cysteine N-palmitoyltransferase HHAT-like protein isoform X2

    Conserved Domains (1) summary
    cl00738
    Location:86 → 235
    MBOAT; membrane-bound O-acyltransferase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D1G3.2 GenPept UniProtKB/Swiss-Prot:Q9D1G3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous