U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Klc4 kinesin light chain 4 [ Mus musculus (house mouse) ]

Gene ID: 74764, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Klc4provided by MGI
Official Full Name
kinesin light chain 4provided by MGI
Primary source
MGI:MGI:1922014
See related
Ensembl:ENSMUSG00000003546 AllianceGenome:MGI:1922014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Knsl8; 1200014P03Rik
Summary
Predicted to be located in cytoplasm and microtubule. Predicted to be part of kinesin complex. Orthologous to human KLC4 (kinesin light chain 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in small intestine adult (RPKM 54.4), duodenum adult (RPKM 41.8) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17 C; 17 22.9 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46941550..46957115, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46630624..46646189, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7535 Neighboring gene microRNA 6976 Neighboring gene serum response factor Neighboring gene PTK7 protein tyrosine kinase 7 Neighboring gene VISTA enhancer mm1620 Neighboring gene STARR-seq mESC enhancer starr_42674 Neighboring gene STARR-seq mESC enhancer starr_42675 Neighboring gene STARR-positive B cell enhancer ABC_E10957 Neighboring gene STARR-positive B cell enhancer ABC_E7536 Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene cullin 7 Neighboring gene STARR-seq mESC enhancer starr_42676 Neighboring gene ribosomal RNA processing 36

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Yang J, et al. Exp Cell Res, 2005 Oct 1. PMID 16018997
  2. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article
  3. Identification of 14-3-3epsilon substrates from embryonic murine brain. Ballif BA, et al. J Proteome Res, 2006 Sep. PMID 16944949
  4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  5. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
kinesin light chain 4
Names
KLC 4
kinesin-like 8
kinesin-like protein 8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357130.1 → NP_001344059.1  kinesin light chain 4

    Status: VALIDATED

    Source sequence(s)
    AK004774, BP765070, CA751873, CF724671
    Consensus CDS
    CCDS28832.1
    UniProtKB/Swiss-Prot
    Q3TCC5, Q9DBS5
    Related
    ENSMUSP00000156564.2, ENSMUST00000233974.2
    Conserved Domains (3) summary
    TIGR02168
    Location:33 → 148
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295 → 323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294 → 369
    TPR_12; Tetratricopeptide repeat

  2. NM_029091.3 → NP_083367.1  kinesin light chain 4

    See identical proteins and their annotated locations for NP_083367.1

    Status: VALIDATED

    Source sequence(s)
    AK004774, BP765070, CA751873, CF724671
    Consensus CDS
    CCDS28832.1
    UniProtKB/Swiss-Prot
    Q3TCC5, Q9DBS5
    Related
    ENSMUSP00000003642.7, ENSMUST00000003642.7
    Conserved Domains (3) summary
    TIGR02168
    Location:33 → 148
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295 → 323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294 → 369
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46941550..46957115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525044.4 → XP_006525107.1  kinesin light chain 4 isoform X2

    Conserved Domains (3) summary
    TIGR02168
    Location:33 → 148
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295 → 323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294 → 369
    TPR_12; Tetratricopeptide repeat

  2. XM_036160817.1 → XP_036016710.1  kinesin light chain 4 isoform X2

    Conserved Domains (3) summary
    TIGR02168
    Location:33 → 148
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295 → 323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294 → 369
    TPR_12; Tetratricopeptide repeat

  3. XM_011246689.3 → XP_011244991.1  kinesin light chain 4 isoform X1

    See identical proteins and their annotated locations for XP_011244991.1

    UniProtKB/Swiss-Prot
    Q3TCC5, Q9DBS5
    Conserved Domains (3) summary
    TIGR02168
    Location:33 → 148
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295 → 323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294 → 369
    TPR_12; Tetratricopeptide repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBS5.1 GenPept UniProtKB/Swiss-Prot:Q9DBS5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous