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C2cd5 C2 calcium-dependent domain containing 5 [ Mus musculus (house mouse) ]

Gene ID: 74741, updated on 5-Mar-2024

Summary

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Official Symbol
C2cd5provided by MGI
Official Full Name
C2 calcium-dependent domain containing 5provided by MGI
Primary source
MGI:MGI:1921991
See related
Ensembl:ENSMUSG00000030279 AllianceGenome:MGI:1921991
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDP138; 5730419I09Rik; C030008B15Rik
Summary
Enables calcium ion binding activity. Involved in insulin receptor signaling pathway via phosphatidylinositol 3-kinase; positive regulation of glucose transmembrane transport; and positive regulation of vesicle fusion. Acts upstream of or within positive regulation of glucose import; protein localization to plasma membrane; and vesicle fusion. Located in plasma membrane. Orthologous to human C2CD5 (C2 calcium dependent domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 8.8), CNS E14 (RPKM 8.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See C2cd5 in Genome Data Viewer
Location:
6 G3; 6 75.13 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142956646..143045878, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (143010920..143100155, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7457 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_17714 Neighboring gene STARR-seq mESC enhancer starr_17715 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:142866014-142866248 Neighboring gene STARR-seq mESC enhancer starr_17718 Neighboring gene predicted gene 7468 Neighboring gene STARR-seq mESC enhancer starr_17722 Neighboring gene STARR-positive B cell enhancer ABC_E2807 Neighboring gene STARR-seq mESC enhancer starr_17724 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:143063726-143063909 Neighboring gene predicted gene, 31108 Neighboring gene STARR-seq mESC enhancer starr_17725 Neighboring gene STARR-positive B cell enhancer ABC_E2808 Neighboring gene STARR-seq mESC enhancer starr_17731 Neighboring gene STARR-positive B cell enhancer ABC_E2215 Neighboring gene STARR-positive B cell enhancer ABC_E2216 Neighboring gene predicted gene, 38921 Neighboring gene ethanolamine kinase 1 Neighboring gene predicted gene, 57769

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hypothalamic C2-domain protein involved in MC4R trafficking and control of energy balance. Gavini CK, et al. Metabolism, 2020 Jan. PMID 31666192
  2. Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release. Zhou QL, et al. Mol Cell Biol, 2018 Apr 15. PMID 29378832, Free PMC Article
  3. A SPAK isoform switch modulates renal salt transport and blood pressure. McCormick JA, et al. Cell Metab, 2011 Sep 7. PMID 21907141, Free PMC Article
  4. C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Xie X, et al. Cell Metab, 2011 Sep 7. PMID 21907143, Free PMC Article
  5. Proteomic analysis of in vivo phosphorylated synaptic proteins. Collins MO, et al. J Biol Chem, 2005 Feb 18. PMID 15572359

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • Kiaa0528

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of glucose import IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of glucose transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of glucose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of vesicle fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of vesicle fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
C2 domain-containing protein 5
Names
138 kDa C2 domain-containing phosphoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109688.2 → NP_001103158.1  C2 domain-containing protein 5 isoform 3

    See identical proteins and their annotated locations for NP_001103158.1

    Status: VALIDATED

    Source sequence(s)
    AC127354, AK141590, AK143732, AK162114, AK163233, AU022314, BC053913
    Consensus CDS
    CCDS51953.1
    UniProtKB/TrEMBL
    Q3TSE2
    Related
    ENSMUSP00000084758.5, ENSMUST00000087485.7
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  2. NM_001286578.1 → NP_001273507.1  C2 domain-containing protein 5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC127354, AK029825, AK143732, AK162114, AK163233, AU022314, BC053913
    UniProtKB/TrEMBL
    Q3TSE2

  3. NM_001362113.1 → NP_001349042.1  C2 domain-containing protein 5 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
    Source sequence(s)
    AC122797, AC127354
    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  4. NM_001362114.1 → NP_001349043.1  C2 domain-containing protein 5 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC122797, AC127354
    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  5. NM_001362115.1 → NP_001349044.1  C2 domain-containing protein 5 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC122797, AC127354
    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  6. NM_001362116.1 → NP_001349045.1  C2 domain-containing protein 5 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC122797, AC127354
    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  7. NM_001362117.1 → NP_001349046.1  C2 domain-containing protein 5 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC122797, AC127354
    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  8. NM_001362118.1 → NP_001349047.1  C2 domain-containing protein 5 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC122797, AC127354

  9. NM_029081.3 → NP_083357.2  C2 domain-containing protein 5 isoform 1

    See identical proteins and their annotated locations for NP_083357.2

    Status: VALIDATED

    Source sequence(s)
    AC127354, AK029825, AK143732, AK162114, AK163233, AU022314, BC053913
    Consensus CDS
    CCDS51952.1
    UniProtKB/Swiss-Prot
    Q3TQY6, Q6A052, Q7TPS5, Q80VA1, Q8C0U3, Q8CID5, Q9CS85
    UniProtKB/TrEMBL
    Q3TSE2
    Related
    ENSMUSP00000145373.2, ENSMUST00000203187.3
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  10. NM_029897.2 → NP_084173.1  C2 domain-containing protein 5 isoform 2

    See identical proteins and their annotated locations for NP_084173.1

    Status: VALIDATED

    Source sequence(s)
    AC127354, AK143732, AK162114, AU022314, BC053913
    Consensus CDS
    CCDS51951.1
    UniProtKB/TrEMBL
    E9Q026, Q3TSE2
    Related
    ENSMUSP00000127834.2, ENSMUST00000171349.8
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    142956646..143045878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321797.3 → XP_017177286.1  C2 domain-containing protein 5 isoform X2

    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (2) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    cl00426
    Location:419 → 457
    YbjQ_1; Putative heavy-metal-binding

  2. XM_017321809.3 → XP_017177298.1  C2 domain-containing protein 5 isoform X12

    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (2) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    cl00426
    Location:408 → 446
    YbjQ_1; Putative heavy-metal-binding

  3. XM_036152375.1 → XP_036008268.1  C2 domain-containing protein 5 isoform X9

    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  4. XM_017321799.3 → XP_017177288.1  C2 domain-containing protein 5 isoform X4

    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (2) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    cl00426
    Location:408 → 446
    YbjQ_1; Putative heavy-metal-binding

  5. XM_017321804.3 → XP_017177293.1  C2 domain-containing protein 5 isoform X8

    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (2) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    cl00426
    Location:430 → 468
    YbjQ_1; Putative heavy-metal-binding

  6. XM_017321801.3 → XP_017177290.1  C2 domain-containing protein 5 isoform X6

    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (2) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    cl00426
    Location:430 → 468
    YbjQ_1; Putative heavy-metal-binding

  7. XM_006506997.5 → XP_006507060.1  C2 domain-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006507060.1

    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (2) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    cl00426
    Location:430 → 468
    YbjQ_1; Putative heavy-metal-binding

  8. XM_036152385.1 → XP_036008278.1  C2 domain-containing protein 5 isoform X22

    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  9. XM_017321802.3 → XP_017177291.1  C2 domain-containing protein 5 isoform X7

    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (2) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    cl00426
    Location:388 → 426
    YbjQ_1; Putative heavy-metal-binding

  10. XM_036152376.1 → XP_036008269.1  C2 domain-containing protein 5 isoform X11

    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  11. XM_017321798.3 → XP_017177287.1  C2 domain-containing protein 5 isoform X3

    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (2) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    cl00426
    Location:410 → 448
    YbjQ_1; Putative heavy-metal-binding

  12. XM_036152377.1 → XP_036008270.1  C2 domain-containing protein 5 isoform X13

    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (1) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone

  13. XM_017321800.3 → XP_017177289.1  C2 domain-containing protein 5 isoform X5

    UniProtKB/TrEMBL
    A0A0N4SW93, Q3TSE2
    Related
    ENSMUSP00000145425.2, ENSMUST00000203673.3
    Conserved Domains (2) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    cl00426
    Location:399 → 437
    YbjQ_1; Putative heavy-metal-binding

  14. XM_017321807.3 → XP_017177296.1  C2 domain-containing protein 5 isoform X10

    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (2) summary
    cd08688
    Location:5 → 114
    C2_KIAA0528-like; C2 domain found in the Human KIAA0528 cDNA clone
    cl00426
    Location:421 → 459
    YbjQ_1; Putative heavy-metal-binding

  15. XM_036152380.1 → XP_036008273.1  C2 domain-containing protein 5 isoform X17

    UniProtKB/TrEMBL
    Q3TSE2

  16. XM_036152379.1 → XP_036008272.1  C2 domain-containing protein 5 isoform X16

    UniProtKB/TrEMBL
    Q3TSE2

  17. XM_036152378.1 → XP_036008271.1  C2 domain-containing protein 5 isoform X15

    UniProtKB/TrEMBL
    Q3TSE2

  18. XM_030255649.2 → XP_030111509.1  C2 domain-containing protein 5 isoform X14

    UniProtKB/TrEMBL
    Q3TSE2
    Conserved Domains (1) summary
    cl00426
    Location:215 → 253
    YbjQ_1; Putative heavy-metal-binding

  19. XM_036152384.1 → XP_036008277.1  C2 domain-containing protein 5 isoform X21

  20. XM_036152381.1 → XP_036008274.1  C2 domain-containing protein 5 isoform X18

    Conserved Domains (1) summary
    cl00426
    Location:112 → 150
    YbjQ_1; Putative heavy-metal-binding

  21. XM_006507009.5 → XP_006507072.1  C2 domain-containing protein 5 isoform X18

  22. XM_036152382.1 → XP_036008275.1  C2 domain-containing protein 5 isoform X19

  23. XM_036152383.1 → XP_036008276.1  C2 domain-containing protein 5 isoform X20

  24. XM_017321813.3 → XP_017177302.1  C2 domain-containing protein 5 isoform X21

RNA

  1. XR_004933628.1 RNA Sequence

    Related
    ENSMUST00000205119.3

  2. XR_004933627.1 RNA Sequence

  3. XR_001785180.3 RNA Sequence

  4. XR_001785182.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TPS5.2 GenPept UniProtKB/Swiss-Prot:Q7TPS5

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