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Rhoh ras homolog family member H [ Mus musculus (house mouse) ]

Gene ID: 74734, updated on 21-Apr-2024

Summary

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Official Symbol
Rhohprovided by MGI
Official Full Name
ras homolog family member Hprovided by MGI
Primary source
MGI:MGI:1921984
See related
Ensembl:ENSMUSG00000029204 AllianceGenome:MGI:1921984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arhh; 5830400A04Rik
Summary
Predicted to enable several functions, including GTP binding activity; GTPase activity; and kinase inhibitor activity. Involved in T cell differentiation and mast cell activation. Located in cytoplasm and immunological synapse. Is expressed in cranial ganglion; dorsal root ganglion; and sensory organ. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human RHOH (ras homolog family member H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 18.6), spleen adult (RPKM 6.0) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C3.1; 5 33.8 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (66018092..66054043)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65860742..65896700)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13273 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66156164-66156347 Neighboring gene NEDD4 binding protein 2 Neighboring gene predicted gene 5296 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66186562-66186763 Neighboring gene predicted gene 3521 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66242163-66242364 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66249264-66249516 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66254646-66254891 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66301684-66301897 Neighboring gene STARR-seq mESC enhancer starr_13274 Neighboring gene predicted gene, 32474 Neighboring gene predicted gene, 32556

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils. Peng S, et al. PLoS Biol, 2022 Sep. PMID 36108062, Free PMC Article
  2. Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting T(H)17 cell polarization. Tamehiro N, et al. J Allergy Clin Immunol, 2019 May. PMID 30339851
  3. A unique carboxyl-terminal insert domain in the hematopoietic-specific, GTPase-deficient Rho GTPase RhoH regulates post-translational processing. Troeger A, et al. J Biol Chem, 2013 Dec 20. PMID 24189071, Free PMC Article
  4. RhoH, a hematopoietic-specific Rho GTPase, regulates proliferation, survival, migration, and engraftment of hematopoietic progenitor cells. Gu Y, et al. Blood, 2005 Feb 15. PMID 15494435
  5. RhoH is a negative regulator of eosinophilopoiesis. Stoeckle C, et al. Cell Death Differ, 2016 Dec. PMID 27740624, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils.
    Title: Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils.
  2. Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma.
    Title: Deletion of murine Rhoh leads to de-repression of Bcl-6 via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma.
  3. RhoH deficiency in mice induced TH17 polarization during effector T-cell differentiation, thereby inducing psoriasis-like chronic dermatitis
    Title: Ras homolog gene family H (RhoH) deficiency induces psoriasis-like chronic dermatitis by promoting T(H)17 cell polarization.
  4. These results highlight a novel negative regulatory role for RhoH in eosinophil differentiation, most likely in consequence of altered GATA-2 levels.
    Title: RhoH is a negative regulator of eosinophilopoiesis.
  5. An excess amount of RhoH is able to initiate pre-TCR signaling in the absence of pre-TCR complexes.
    Title: Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.
  6. The C-terminal insert domain regulates RhoH protein stability via chaperone-mediated autophagy.
    Title: A unique carboxyl-terminal insert domain in the hematopoietic-specific, GTPase-deficient Rho GTPase RhoH regulates post-translational processing.
  7. RhoH plays a critical role in prosurvival chronic lymphocytic leukemia cell-cell and cell-microenvironment interactions with this agent.
    Title: RhoH is critical for cell-microenvironment interactions in chronic lymphocytic leukemia in mice and humans.
  8. Results suggest that RhoH regulates TCR signaling via recruitment of ZAP-70 and Lck to CD3zeta in the immunological synapse.
    Title: RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling.
  9. These findings stress the importance of Rhoh for the function of peripheral T cells.
    Title: Rhoh deficiency reduces peripheral T-cell function and attenuates allogenic transplant rejection.
  10. RhoH has a function in the progression of B-cell chronic lymphocytic leukemia (CLL) in a murine model and show RhoH expression is altered in human primary lymphocytic (CLL) samples.
    Title: Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in T cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mast cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in immunological synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rho-related GTP-binding protein RhoH
Names
ras homolog gene family, member H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081105.2 → NP_001074574.1  rho-related GTP-binding protein RhoH

    See identical proteins and their annotated locations for NP_001074574.1

    Status: VALIDATED

    Source sequence(s)
    AC156029
    Consensus CDS
    CCDS39100.1
    UniProtKB/Swiss-Prot
    Q9D3G9
    UniProtKB/TrEMBL
    Q3TEI3, Q504M6
    Related
    ENSMUSP00000143810.2, ENSMUST00000201533.2
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  2. NM_001363454.1 → NP_001350383.1  rho-related GTP-binding protein RhoH

    Status: VALIDATED

    Source sequence(s)
    AC156029, AI448508, AK137909, AK138090
    Consensus CDS
    CCDS39100.1
    UniProtKB/Swiss-Prot
    Q9D3G9
    UniProtKB/TrEMBL
    Q3TEI3, Q504M6
    Related
    ENSMUSP00000031106.5, ENSMUST00000031106.8
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    66018092..66054043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254861.2 → XP_030110721.1  rho-related GTP-binding protein RhoH isoform X1

    UniProtKB/Swiss-Prot
    Q9D3G9
    UniProtKB/TrEMBL
    Q3TEI3, Q504M6
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  2. XM_011240779.4 → XP_011239081.1  rho-related GTP-binding protein RhoH isoform X1

    See identical proteins and their annotated locations for XP_011239081.1

    UniProtKB/Swiss-Prot
    Q9D3G9
    UniProtKB/TrEMBL
    Q3TEI3, Q504M6
    Conserved Domains (1) summary
    cd00157
    Location:5 → 169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3G9.1 GenPept UniProtKB/Swiss-Prot:Q9D3G9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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