Wbp2nl WBP2 N-terminal like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wbp2nlprovided by MGI
Official Full Name: WBP2 N-terminal likeprovided by MGI
Primary source: MGI:MGI:1921966
See related: Ensembl:ENSMUSG00000022455 AllianceGenome:MGI:1921966
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAWP; 4930521I23Rik
Summary: Predicted to enable WW domain binding activity; chromatin DNA binding activity; and transcription coactivator activity. Predicted to be involved in egg activation; male pronucleus assembly; and positive regulation of transcription, DNA-templated. Predicted to act upstream of or within female pronucleus assembly. Predicted to be located in perinuclear theca; sperm flagellum; and sperm head. Predicted to be active in nucleus. Orthologous to human WBP2NL (WBP2 N-terminal like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 60.3) See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 38.56 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (82183126..82198848)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (82298925..82314647)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PAWP does not play an essential role in mouse fertilization
Title: Sperm postacrosomal WW domain-binding protein is not required for mouse egg activation.
The data suggest that sperm-derived PAWP is not involved in triggering Ca(2+) oscillations at fertilization in mammalian oocytes.
Title: Sperm-specific post-acrosomal WW-domain binding protein (PAWP) does not cause Ca2+ release in mouse oocytes.
These results indicate that PAWP plays a role in spermatogenesis and germ cell development. Moreover, we suggest PAWP as one of the markers that could be looked in ESC studies as a confirmed testis-specific gene
Title: Expression analysis of PAWP during mouse embryonic stem cell-based spermatogenesis in vitro.
The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport
Title: The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables WW domain binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in egg activation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within female pronucleus assembly	ISO Inferred from Sequence Orthology more info	PubMed
involved_in male pronucleus assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear theca	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm head	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: postacrosomal sheath WW domain-binding protein

Names: WW domain-binding protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029066.1 → NP_083342.1 postacrosomal sheath WW domain-binding protein

See identical proteins and their annotated locations for NP_083342.1

Status: PROVISIONAL

Source sequence(s)

BC119520

Consensus CDS

CCDS37158.1

UniProtKB/Swiss-Prot

Q9D529

Related

ENSMUSP00000023089.4, ENSMUST00000023089.5

Conserved Domains (3) summary

cd13214
Location:31 → 129

PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

pfam10349
Location:103 → 225

WWbp; WW-domain ligand protein

cl23807
Location:254 → 327

WWbp; WW-domain ligand protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

82183126..82198848

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316772.2 → XP_017172261.1 postacrosomal sheath WW domain-binding protein isoform X1

Conserved Domains (2) summary

PTZ00436
Location:182 → 345

PTZ00436; 60S ribosomal protein L19-like protein; Provisional

cd13214
Location:48 → 146

PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain