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Ttll9 tubulin tyrosine ligase-like family, member 9 [ Mus musculus (house mouse) ]

Gene ID: 74711, updated on 21-Apr-2024

Summary

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Official Symbol
Ttll9provided by MGI
Official Full Name
tubulin tyrosine ligase-like family, member 9provided by MGI
Primary source
MGI:MGI:1913589
See related
Ensembl:ENSMUSG00000074673 AllianceGenome:MGI:1913589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700016F23Rik; 4930509O20Rik
Summary
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Acts upstream of or within flagellated sperm motility and protein polyglutamylation. Located in ciliary basal body. Orthologous to human TTLL9 (tubulin tyrosine ligase like 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 39.3) and genital fat pad adult (RPKM 1.2) See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 75.41 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152792966..152850402)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152951046..153008482)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10154 Neighboring gene myosin, light polypeptide kinase 2, skeletal muscle Neighboring gene forkhead box S1 Neighboring gene STARR-seq mESC enhancer starr_06085 Neighboring gene dual specificity phosphatase-like 15 Neighboring gene STARR-seq mESC enhancer starr_06086 Neighboring gene predicted gene 14199 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152840956-152841257 Neighboring gene p53 and DNA damage regulated 1 Neighboring gene X-linked Kx blood group related 7 Neighboring gene predicted gene, 32286

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ttll9-/- mice sperm flagella show shortening of doublet 7, reduction of doublet 5 polyglutamylation and a stall in beating. Konno A, et al. J Cell Sci, 2016 Jul 15. PMID 27257088
  2. A targeted multienzyme mechanism for selective microtubule polyglutamylation. van Dijk J, et al. Mol Cell, 2007 May 11. PMID 17499049
  3. Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Ye B, et al. Nat Commun, 2018 Mar 28. PMID 29593216, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ttll9 plays essential roles in maintaining the normal structure and beating pattern of sperm flagella by establishing normal heterogeneous polyglutamylation patterns.
    Title: Ttll9-/- mice sperm flagella show shortening of doublet 7, reduction of doublet 5 polyglutamylation and a stall in beating.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein polyglutamylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable tubulin polyglutamylase TTLL9
Names
putative polyglutamylase
tubulin tyrosine ligase like family 9
tubulin--tyrosine ligase-like protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083618.1 → NP_001077087.1  probable tubulin polyglutamylase TTLL9 isoform 1

    See identical proteins and their annotated locations for NP_001077087.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 2.
    Source sequence(s)
    AK006027, AK015388, AK041200
    Consensus CDS
    CCDS38283.1
    UniProtKB/Swiss-Prot
    A2APC3, A2APC4, A2APC5, A2APC6, Q9D570
    Related
    ENSMUSP00000096803.3, ENSMUST00000099197.9
    Conserved Domains (1) summary
    pfam03133
    Location:74 → 390
    TTL; Tubulin-tyrosine ligase family

  2. NM_001355717.1 → NP_001342646.1  probable tubulin polyglutamylase TTLL9 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate coding exons compared to variant 2. The resulting isoform (3) differs in the N-terminus and lacks an alternate internal segment compared to isoform 2.
    Source sequence(s)
    AL833801, AL928862
    UniProtKB/TrEMBL
    A7E1Z2
    Conserved Domains (1) summary
    cl17255
    Location:31 → 328
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  3. NM_001355719.1 → NP_001342648.1  probable tubulin polyglutamylase TTLL9 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 2. The resulting isoform (4) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 2.
    Source sequence(s)
    AL833801, AL928862
    UniProtKB/TrEMBL
    A7E1Z2
    Conserved Domains (1) summary
    cl17255
    Location:31 → 328
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  4. NM_001355720.1 → NP_001342649.1  probable tubulin polyglutamylase TTLL9 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction compared to variant 2. The resulting isoform (5) is shorter at the N-terminus compared to isoform 2.
    Source sequence(s)
    AL833801, AL928862
    UniProtKB/TrEMBL
    A7E1Z2
    Conserved Domains (1) summary
    pfam03133
    Location:1 → 296
    TTL; Tubulin-tyrosine ligase family

  5. NM_029064.2 → NP_083340.2  probable tubulin polyglutamylase TTLL9 isoform 2

    See identical proteins and their annotated locations for NP_083340.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AK006027, AK015740, AL833801
    Consensus CDS
    CCDS16903.1
    UniProtKB/TrEMBL
    A7E1Z2
    Related
    ENSMUSP00000099444.4, ENSMUST00000103155.10
    Conserved Domains (1) summary
    pfam03133
    Location:74 → 390
    TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152792966..152850402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252160.1 → XP_030108020.1  probable tubulin polyglutamylase TTLL9 isoform X6

    UniProtKB/TrEMBL
    A7E1Z2
    Conserved Domains (1) summary
    pfam03133
    Location:1 → 296
    TTL; Tubulin-tyrosine ligase family

  2. XM_030252156.2 → XP_030108016.1  probable tubulin polyglutamylase TTLL9 isoform X4

    UniProtKB/TrEMBL
    A7E1Z2
    Conserved Domains (1) summary
    pfam03133
    Location:42 → 358
    TTL; Tubulin-tyrosine ligase family

  3. XM_030252153.2 → XP_030108013.1  probable tubulin polyglutamylase TTLL9 isoform X2

    UniProtKB/TrEMBL
    A7E1Z2
    Conserved Domains (1) summary
    pfam03133
    Location:63 → 379
    TTL; Tubulin-tyrosine ligase family

  4. XM_030252155.2 → XP_030108015.1  probable tubulin polyglutamylase TTLL9 isoform X4

    UniProtKB/TrEMBL
    A7E1Z2
    Conserved Domains (1) summary
    pfam03133
    Location:42 → 358
    TTL; Tubulin-tyrosine ligase family

  5. XM_030252161.2 → XP_030108021.1  probable tubulin polyglutamylase TTLL9 isoform X8

    UniProtKB/TrEMBL
    A7E1Z2
    Conserved Domains (1) summary
    cl17255
    Location:58 → 296
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  6. XM_030252158.1 → XP_030108018.1  probable tubulin polyglutamylase TTLL9 isoform X5

    UniProtKB/TrEMBL
    A7E1Z2
    Conserved Domains (1) summary
    pfam03133
    Location:42 → 358
    TTL; Tubulin-tyrosine ligase family

  7. XM_030252157.2 → XP_030108017.1  probable tubulin polyglutamylase TTLL9 isoform X4

    UniProtKB/TrEMBL
    A7E1Z2
    Conserved Domains (1) summary
    pfam03133
    Location:42 → 358
    TTL; Tubulin-tyrosine ligase family

  8. XM_030252152.1 → XP_030108012.1  probable tubulin polyglutamylase TTLL9 isoform X1

    UniProtKB/TrEMBL
    A7E1Z2
    Conserved Domains (1) summary
    pfam03133
    Location:74 → 390
    TTL; Tubulin-tyrosine ligase family

  9. XM_006500320.2 → XP_006500383.1  probable tubulin polyglutamylase TTLL9 isoform X7

    Conserved Domains (1) summary
    pfam03133
    Location:1 → 296
    TTL; Tubulin-tyrosine ligase family

  10. XM_030252154.1 → XP_030108014.1  probable tubulin polyglutamylase TTLL9 isoform X3

    UniProtKB/TrEMBL
    A7E1Z2
    Conserved Domains (1) summary
    pfam03133
    Location:63 → 379
    TTL; Tubulin-tyrosine ligase family

  11. XM_030252159.1 → XP_030108019.1  probable tubulin polyglutamylase TTLL9 isoform X5

    UniProtKB/TrEMBL
    A7E1Z2
    Conserved Domains (1) summary
    pfam03133
    Location:42 → 358
    TTL; Tubulin-tyrosine ligase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2APC3.2 GenPept UniProtKB/Swiss-Prot:A2APC3

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