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S100pbp S100P binding protein [ Mus musculus (house mouse) ]

Gene ID: 74648, updated on 5-Mar-2024

Summary

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Official Symbol
S100pbpprovided by MGI
Official Full Name
S100P binding proteinprovided by MGI
Primary source
MGI:MGI:1921898
See related
Ensembl:ENSMUSG00000040928 AllianceGenome:MGI:1921898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S100pbpr; 4930429A08Rik
Summary
Predicted to enable calcium-dependent protein binding activity. Predicted to be located in nuclear speck. Predicted to be active in cytosol and nucleus. Orthologous to human S100PBP (S100P binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 14.2), CNS E11.5 (RPKM 9.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 62.96 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129041795..129083485, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129148002..129189665, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 54 Neighboring gene STARR-positive B cell enhancer ABC_E4669 Neighboring gene hippocalcin Neighboring gene fibronectin type III domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E3517 Neighboring gene STARR-seq mESC enhancer starr_11478 Neighboring gene tyrosyl-tRNA synthetase 1 Neighboring gene STARR-seq mESC enhancer starr_11480 Neighboring gene NHS like 3 Neighboring gene STARR-seq mESC enhancer starr_11482 Neighboring gene predicted gene 12976

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. S100PBP is regulated by mutated KRAS and plays a tumour suppressor role in pancreatic cancer.
    Title: S100PBP is regulated by mutated KRAS and plays a tumour suppressor role in pancreatic cancer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
S100P-binding protein

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347203.2 → NP_001334132.1  S100P-binding protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 9 and 10, encodes isoform 2.
    Source sequence(s)
    AL606977
    Consensus CDS
    CCDS84797.1
    UniProtKB/Swiss-Prot
    Q9D5K4
    Related
    ENSMUSP00000101674.2, ENSMUST00000106059.8
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 263
    S100PBPR; S100P-binding protein

  2. NM_001361317.2 → NP_001348246.1  S100P-binding protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 11, encodes isoform 3.
    Source sequence(s)
    AL606977
    Consensus CDS
    CCDS89830.1
    UniProtKB/TrEMBL
    E9Q5M3
    Related
    ENSMUSP00000072258.7, ENSMUST00000072431.13
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 304
    S100PBPR; S100P-binding protein

  3. NM_001379588.1 → NP_001366517.1  S100P-binding protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4-8 all encode the same isoform (1).
    Source sequence(s)
    AL606977
    UniProtKB/Swiss-Prot
    A2A7S5, Q3UJU0, Q3UTU1, Q3V367, Q8BSS8, Q8C925, Q8CHX8, Q9D5K4
    UniProtKB/TrEMBL
    E9Q5M3
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 382
    S100PBPR; S100P-binding protein

  4. NM_001379589.1 → NP_001366518.1  S100P-binding protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 4, and 6-8, encodes isoform 1.
    Source sequence(s)
    AL606977
    UniProtKB/Swiss-Prot
    A2A7S5, Q3UJU0, Q3UTU1, Q3V367, Q8BSS8, Q8C925, Q8CHX8, Q9D5K4
    UniProtKB/TrEMBL
    E9Q5M3
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 382
    S100PBPR; S100P-binding protein

  5. NM_001379590.1 → NP_001366519.1  S100P-binding protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 4, 5, 7, and 8, encodes isoform 1.
    Source sequence(s)
    AL606977
    UniProtKB/Swiss-Prot
    A2A7S5, Q3UJU0, Q3UTU1, Q3V367, Q8BSS8, Q8C925, Q8CHX8, Q9D5K4
    UniProtKB/TrEMBL
    E9Q5M3
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 382
    S100PBPR; S100P-binding protein

  6. NM_001379591.1 → NP_001366520.1  S100P-binding protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 4-6, and 8, encodes isoform 1.
    Source sequence(s)
    AL606977
    UniProtKB/Swiss-Prot
    A2A7S5, Q3UJU0, Q3UTU1, Q3V367, Q8BSS8, Q8C925, Q8CHX8, Q9D5K4
    UniProtKB/TrEMBL
    E9Q5M3
    Related
    ENSMUSP00000039820.6, ENSMUST00000049081.12
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 382
    S100PBPR; S100P-binding protein

  7. NM_001379592.1 → NP_001366521.1  S100P-binding protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 1 and 4-7, encodes isoform 1.
    Source sequence(s)
    AL606977
    UniProtKB/Swiss-Prot
    A2A7S5, Q3UJU0, Q3UTU1, Q3V367, Q8BSS8, Q8C925, Q8CHX8, Q9D5K4
    UniProtKB/TrEMBL
    E9Q5M3
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 382
    S100PBPR; S100P-binding protein

  8. NM_001379593.1 → NP_001366522.1  S100P-binding protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 2 and 10, encodes isoform 2.
    Source sequence(s)
    AL606977
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 263
    S100PBPR; S100P-binding protein

  9. NM_001379594.1 → NP_001366523.1  S100P-binding protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 2 and 9, encodes isoform 2.
    Source sequence(s)
    AL606977
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 263
    S100PBPR; S100P-binding protein

  10. NM_001379595.1 → NP_001366524.1  S100P-binding protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variant 3, encodes isoform 3.
    Source sequence(s)
    AL606977
    UniProtKB/TrEMBL
    E9Q5M3
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 304
    S100PBPR; S100P-binding protein

  11. NM_001379596.1 → NP_001366525.1  S100P-binding protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform 4.
    Source sequence(s)
    AL606977
    UniProtKB/TrEMBL
    E9Q5M3
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 340
    S100PBPR; S100P-binding protein

  12. NM_001379597.1 → NP_001366526.1  S100P-binding protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform 4.
    Source sequence(s)
    AL606977
    UniProtKB/TrEMBL
    E9Q5M3
    Related
    ENSMUSP00000113084.2, ENSMUST00000117497.8
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 340
    S100PBPR; S100P-binding protein

  13. NM_001379598.1 → NP_001366527.1  S100P-binding protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform 4.
    Source sequence(s)
    AL606977
    UniProtKB/TrEMBL
    E9Q5M3
    Related
    ENSMUSP00000113920.2, ENSMUST00000117965.8
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 340
    S100PBPR; S100P-binding protein

  14. NM_001379599.1 → NP_001366528.1  S100P-binding protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL606977
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 305
    S100PBPR; S100P-binding protein

  15. NM_029036.4 → NP_083312.1  S100P-binding protein isoform 1

    See identical proteins and their annotated locations for NP_083312.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1 and 4-8 all encode the same isoform (1).
    Source sequence(s)
    AL606977
    Consensus CDS
    CCDS18684.1
    UniProtKB/Swiss-Prot
    A2A7S5, Q3UJU0, Q3UTU1, Q3V367, Q8BSS8, Q8C925, Q8CHX8, Q9D5K4
    UniProtKB/TrEMBL
    E9Q5M3
    Related
    ENSMUSP00000101676.3, ENSMUST00000106061.9
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 382
    S100PBPR; S100P-binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    129041795..129083485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503448.4 → XP_006503511.1  S100P-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006503511.1

    UniProtKB/Swiss-Prot
    A2A7S5, Q3UJU0, Q3UTU1, Q3V367, Q8BSS8, Q8C925, Q8CHX8, Q9D5K4
    UniProtKB/TrEMBL
    E9Q5M3
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 382
    S100PBPR; S100P-binding protein

  2. XM_036164504.1 → XP_036020397.1  S100P-binding protein isoform X2

    UniProtKB/TrEMBL
    E9Q5M3
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 346
    S100PBPR; S100P-binding protein

  3. XM_036164507.1 → XP_036020400.1  S100P-binding protein isoform X4

    UniProtKB/TrEMBL
    E9Q5M3
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 304
    S100PBPR; S100P-binding protein

  4. XM_036164505.1 → XP_036020398.1  S100P-binding protein isoform X3

    UniProtKB/TrEMBL
    E9Q5M3
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 340
    S100PBPR; S100P-binding protein

  5. XM_036164506.1 → XP_036020399.1  S100P-binding protein isoform X4

    UniProtKB/TrEMBL
    E9Q5M3
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 304
    S100PBPR; S100P-binding protein

  6. XM_006503446.5 → XP_006503509.1  S100P-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006503509.1

    UniProtKB/Swiss-Prot
    A2A7S5, Q3UJU0, Q3UTU1, Q3V367, Q8BSS8, Q8C925, Q8CHX8, Q9D5K4
    UniProtKB/TrEMBL
    E9Q5M3
    Conserved Domains (1) summary
    pfam15427
    Location:21 → 382
    S100PBPR; S100P-binding protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D5K4.1 GenPept UniProtKB/Swiss-Prot:Q9D5K4

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