U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 [ Mus musculus (house mouse) ]

Gene ID: 74646, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Spsb1provided by MGI
Official Full Name
splA/ryanodine receptor domain and SOCS box containing 1provided by MGI
Primary source
MGI:MGI:1921896
See related
Ensembl:ENSMUSG00000039911 AllianceGenome:MGI:1921896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SSB1; SSB-1; 1110014L01Rik; 4930422J18Rik
Summary
Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in cytosol. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 81.3), testis adult (RPKM 13.6) and 15 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 E2; 4 80.46 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149980740..150039494, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149896283..149955006, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12127 Neighboring gene STARR-positive B cell enhancer ABC_E3555 Neighboring gene predicted gene, 42354 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:149230571-149230822 Neighboring gene predicted gene, 54270 Neighboring gene STARR-seq mESC enhancer starr_12128 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:149250416-149250525 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:149254138-149254291 Neighboring gene STARR-seq mESC enhancer starr_12129 Neighboring gene STARR-seq mESC enhancer starr_12130 Neighboring gene predicted gene 13070 Neighboring gene STARR-seq mESC enhancer starr_12131 Neighboring gene STARR-positive B cell enhancer ABC_E3556 Neighboring gene STARR-positive B cell enhancer ABC_E4732 Neighboring gene STARR-positive B cell enhancer mm9_chr4:149363044-149363345 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:149365064-149365305 Neighboring gene STARR-seq mESC enhancer starr_12133 Neighboring gene hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) Neighboring gene predicted gene 13067 Neighboring gene STARR-seq mESC enhancer starr_12135

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Divergence of the vertebrate sp1A/ryanodine receptor domain and SOCS box-containing (Spsb) gene family and its expression and regulation within the mouse brain. Kleiber ML, et al. Genomics, 2009 Apr. PMID 19101625
  2. SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling. Feng Y, et al. Cancer Discov, 2014 Jul. PMID 24786206, Free PMC Article
  3. TLR regulation of SPSB1 controls inducible nitric oxide synthase induction. Lewis RS, et al. J Immunol, 2011 Oct 1. PMID 21876038
  4. SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-β Signaling Pathway Targeting the Type II Receptor. Liu S, et al. J Biol Chem, 2015 Jul 17. PMID 26032413, Free PMC Article
  5. Murine homologues of the Drosophila gustavus gene are expressed in ovarian granulosa cells. Xing Y, et al. Reproduction, 2006 May. PMID 16672355, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SPSB1-mediated inhibition of TGF-beta receptor-II impairs myogenesis in inflammation.
    Title: SPSB1-mediated inhibition of TGF-β receptor-II impairs myogenesis in inflammation.
  2. these results establish SSB1/2 as safeguards of B cell development and unveil their differential requirement in immature and mature B lymphocytes
    Title: SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors.
  3. Collectively, Ssb1 and Ssb2 control crucial aspects of Hematopoietic stem and progenitor cells function, including proliferation and survival in vivo by resolving replicative stress to maintain genomic stability.
    Title: Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.
  4. SPSB1 negatively regulates the TGF-beta signaling pathway through its interaction with both endogenous and overexpressed TbetaRII (and not TbetaRI) via its Spry domain.
    Title: SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-β Signaling Pathway Targeting the Type II Receptor.
  5. Findings define a novel pathway that contributes to breast cancer recurrence and provide evidence implicating SPSB proteins in cancer.
    Title: SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling.
  6. Collectively, these results demonstrate essential roles of Ssb1 in embryogenesis, spermatogenesis, and genome stability in vivo.
    Title: Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2.
  7. These results suggest that SPSB1 acts through a negative-feedback loop that, together with SPSB2, controls the extent of iNOS induction and nitric oxide production.
    Title: TLR regulation of SPSB1 controls inducible nitric oxide synthase induction.
  8. SPSB1 and SPSB4 bind strongly to both Par-4 and VASA peptides.
    Title: Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
  9. Spsb1 is responsive to stress caused by ethanol exposure in the mouse brain, which suggests that Spsb genes have acquired different regulatory mechanisms.
    Title: Divergence of the vertebrate sp1A/ryanodine receptor domain and SOCS box-containing (Spsb) gene family and its expression and regulation within the mouse brain.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC102221

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
SPRY domain-containing SOCS box protein 1
Names
SPRY domain-containing SOCS box protein SSB-1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419256.1 → NP_001406185.1  SPRY domain-containing SOCS box protein 1

    Status: VALIDATED

    Source sequence(s)
    AL606914
    UniProtKB/Swiss-Prot
    Q5FWI0, Q8BJA4, Q9D5L7

  2. NM_001419257.1 → NP_001406186.1  SPRY domain-containing SOCS box protein 1

    Status: VALIDATED

    Source sequence(s)
    AL606914
    UniProtKB/Swiss-Prot
    Q5FWI0, Q8BJA4, Q9D5L7

  3. NM_001419258.1 → NP_001406187.1  SPRY domain-containing SOCS box protein 1

    Status: VALIDATED

    Source sequence(s)
    AL606914
    UniProtKB/Swiss-Prot
    Q5FWI0, Q8BJA4, Q9D5L7
    Related
    ENSMUSP00000101309.2, ENSMUST00000105684.2

  4. NM_001419259.1 → NP_001406188.1  SPRY domain-containing SOCS box protein 1

    Status: VALIDATED

    Source sequence(s)
    AL606914
    UniProtKB/Swiss-Prot
    Q5FWI0, Q8BJA4, Q9D5L7

  5. NM_029035.3 → NP_083311.1  SPRY domain-containing SOCS box protein 1

    See identical proteins and their annotated locations for NP_083311.1

    Status: VALIDATED

    Source sequence(s)
    AL606914
    Consensus CDS
    CCDS18966.1
    UniProtKB/Swiss-Prot
    Q5FWI0, Q8BJA4, Q9D5L7
    Related
    ENSMUSP00000048969.3, ENSMUST00000038562.9
    Conserved Domains (2) summary
    cd12906
    Location:54 → 227
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
    cl02533
    Location:232 → 273
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    149980740..150039494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539234.4 → XP_006539297.1  SPRY domain-containing SOCS box protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006539297.1

    UniProtKB/Swiss-Prot
    Q5FWI0, Q8BJA4, Q9D5L7
    Related
    ENSMUSP00000101310.2, ENSMUST00000105685.2
    Conserved Domains (2) summary
    cd12906
    Location:54 → 227
    SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
    cl02533
    Location:232 → 273
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D5L7.1 GenPept UniProtKB/Swiss-Prot:Q9D5L7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous