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Scrn3 secernin 3 [ Mus musculus (house mouse) ]

Gene ID: 74616, updated on 5-Mar-2024

Summary

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Official Symbol
Scrn3provided by MGI
Official Full Name
secernin 3provided by MGI
Primary source
MGI:MGI:1921866
See related
Ensembl:ENSMUSG00000008226 AllianceGenome:MGI:1921866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ses3; 4833415E20Rik
Summary
Predicted to enable cysteine-type exopeptidase activity and dipeptidase activity. Predicted to be involved in proteolysis. Orthologous to human SCRN3 (secernin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 6.8), liver E14.5 (RPKM 6.1) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C3; 2 43.57 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (73142980..73168158)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (73312650..73337818)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene trans-acting transcription factor 9 Neighboring gene corepressor interacting with RBPJ, 1 Neighboring gene STARR-positive B cell enhancer ABC_E2622 Neighboring gene STARR-seq mESC enhancer starr_04837 Neighboring gene G protein-coupled receptor 155 Neighboring gene predicted gene 13709 Neighboring gene STARR-positive B cell enhancer mm9_chr2:73224453-73224754 Neighboring gene predicted gene 13707 Neighboring gene WAS/WASL interacting protein family, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phenelzine-based probes reveal Secernin-3 is involved in thermal nociception. Bustin KA, et al. Mol Cell Neurosci, 2023 Jun. PMID 36924917,
  2. The Sertoli cell expressed gene secernin-1 (Scrn1) is dispensable for male fertility in the mouse. Houston BJ, et al. Dev Dyn, 2021 Jul. PMID 33442887, Free PMC Article
  3. Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells. Way G, et al. Mol Biol Cell, 2002 Sep. PMID 12221138, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type exopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
secernin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355711.1 → NP_001342640.1  secernin-3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK050521, BY203757, BY695942
    Consensus CDS
    CCDS89499.1
    UniProtKB/TrEMBL
    A2AWQ9, Q6P6J8
    Related
    ENSMUSP00000107681.2, ENSMUST00000112050.2
    Conserved Domains (1) summary
    cl00467
    Location:5 → 178
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

  2. NM_029022.1 → NP_083298.1  secernin-3 isoform 1

    See identical proteins and their annotated locations for NP_083298.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK014701, AK028703, AV002033, BE945683, BY203757
    Consensus CDS
    CCDS16128.1
    UniProtKB/Swiss-Prot
    A2AWR0, Q3TMH2, Q91WF6, Q9CUT0
    Related
    ENSMUSP00000088320.5, ENSMUST00000090811.11
    Conserved Domains (1) summary
    cl00467
    Location:5 → 224
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    73142980..73168158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162646.1 → XP_036018539.1  secernin-3 isoform X2

    UniProtKB/Swiss-Prot
    A2AWR0, Q3TMH2, Q91WF6, Q9CUT0
    Conserved Domains (1) summary
    cl00467
    Location:5 → 224
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

  2. XM_011239820.4 → XP_011238122.1  secernin-3 isoform X3

  3. XM_006500313.5 → XP_006500376.1  secernin-3 isoform X1

    Conserved Domains (1) summary
    cl00467
    Location:28 → 247
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

RNA

  1. XR_866344.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TMH2.1 GenPept UniProtKB/Swiss-Prot:Q3TMH2

Gene LinkOut

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