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Sppl3 signal peptide peptidase 3 [ Mus musculus (house mouse) ]

Gene ID: 74585, updated on 21-Apr-2024

Summary

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Official Symbol
Sppl3provided by MGI
Official Full Name
signal peptide peptidase 3provided by MGI
Primary source
MGI:MGI:1891433
See related
Ensembl:ENSMUSG00000029550 AllianceGenome:MGI:1891433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Psl4; Usmg3; 4833416I09Rik
Summary
Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of cytosolic calcium ion concentration. Located in endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in central nervous system; gonad; retina; and vibrissa. Orthologous to human SPPL3 (signal peptide peptidase like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 71.9), limb E14.5 (RPKM 43.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 55.99 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115149204..115236849)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115011524..115098790)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2210016L21 gene Neighboring gene STARR-positive B cell enhancer ABC_E1057 Neighboring gene HNF1 homeobox A Neighboring gene STARR-seq mESC enhancer starr_14093 Neighboring gene HNF1 homeobox A, opposite strand 1 Neighboring gene STARR-seq mESC enhancer starr_14096 Neighboring gene STARR-seq mESC enhancer starr_14098 Neighboring gene STARR-seq mESC enhancer starr_14099 Neighboring gene predicted gene, 54336 Neighboring gene ribosomal protein L37, retrotransposed Neighboring gene acyl-Coenzyme A dehydrogenase, short chain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways. Kuhn PH, et al. Mol Cell Proteomics, 2015 Jun. PMID 25827571, Free PMC Article
  2. Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. Voss M, et al. EMBO J, 2014 Dec 17. PMID 25354954, Free PMC Article
  3. NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3. Hamblet CE, et al. J Immunol, 2016 Mar 15. PMID 26851218, Free PMC Article
  4. A protease-independent function for SPPL3 in NFAT activation. Makowski SL, et al. Mol Cell Biol, 2015 Jan. PMID 25384971, Free PMC Article
  5. Large-scale screen for genes involved in gonad development. Wertz K, et al. Mech Dev, 2000 Nov. PMID 11044607

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our results identify SPPL3 as a cell-autonomous molecular determinant of NK cell maturation
    Title: NK Cell Maturation and Cytotoxicity Are Controlled by the Intramembrane Aspartyl Protease SPPL3.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC90867

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartic endopeptidase activity, intramembrane cleaving ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane protein proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane protein proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcineurin-NFAT signaling cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi-associated vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi-associated vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic side of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in lumenal side of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lumenal side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal peptide peptidase-like 3
Names
IMP-2
SPP-like 3 protein
intramembrane protease 2
presenilin-like protein 4
upregulated during skeletal muscle growth 3
NP_083288.2
XP_017176612.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029012.2 → NP_083288.2  signal peptide peptidase-like 3

    See identical proteins and their annotated locations for NP_083288.2

    Status: VALIDATED

    Source sequence(s)
    AK014709, BU613738, CAAA01026347, CD806412
    Consensus CDS
    CCDS19578.1
    UniProtKB/Swiss-Prot
    E9QP88, Q8R597, Q9CUS9
    UniProtKB/TrEMBL
    Q5RJH9
    Related
    ENSMUSP00000031530.6, ENSMUST00000031530.9
    Conserved Domains (1) summary
    pfam04258
    Location:61 → 374
    Peptidase_A22B; Signal peptide peptidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115149204..115236849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321123.3 → XP_017176612.1  signal peptide peptidase-like 3 isoform X1

    Conserved Domains (1) summary
    pfam04258
    Location:1 → 288
    Peptidase_A22B; Signal peptide peptidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CUS9.3 GenPept UniProtKB/Swiss-Prot:Q9CUS9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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