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Lvrn laeverin [ Mus musculus (house mouse) ]

Gene ID: 74574, updated on 5-Mar-2024

Summary

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Official Symbol
Lvrnprovided by MGI
Official Full Name
laeverinprovided by MGI
Primary source
MGI:MGI:1921824
See related
Ensembl:ENSMUSG00000024481 AllianceGenome:MGI:1921824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APQ; AP-Q; Aqpep; 4833403I15Rik
Summary
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including peptide catabolic process; proteolysis; and regulation of blood pressure. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including brain; genitourinary system; heart; and skin. Orthologous to human LVRN (laeverin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 1.3), bladder adult (RPKM 0.6) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 C; 18 24.84 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (46983106..47040313)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (46848826..46907246)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr18:46901062-46901363 Neighboring gene autophagy related 12 Neighboring gene adaptor-related protein complex 3, sigma 1 subunit Neighboring gene STARR-seq mESC enhancer starr_44521 Neighboring gene STARR-seq mESC enhancer starr_44523 Neighboring gene predicted gene, 23610 Neighboring gene ADP-ribosylation factor-like 14 effector protein-like Neighboring gene STARR-seq mESC enhancer starr_44529 Neighboring gene predicted gene 3744

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lvrn expression is not critical for mouse placentation. Tobita T, et al. J Reprod Dev, 2019 Jun 14. PMID 30745494, Free PMC Article
  2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC130603

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aminopeptidase Q

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029008.1 → NP_083284.1  aminopeptidase Q

    Status: VALIDATED

    Source sequence(s)
    AC122801, AC132100
    Consensus CDS
    CCDS50284.1
    UniProtKB/TrEMBL
    E9QJR0
    Related
    ENSMUSP00000025358.3, ENSMUST00000025358.4
    Conserved Domains (3) summary
    cd09601
    Location:102 → 575
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:94 → 504
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:646 → 964
    ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    46983106..47040313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161298.1 → XP_036017191.1  aminopeptidase Q isoform X1

    Conserved Domains (2) summary
    cd09601
    Location:6 → 316
    M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
    pfam11838
    Location:391 → 710
    ERAP1_C; ERAP1-like C-terminal domain

  2. XM_036161299.1 → XP_036017192.1  aminopeptidase Q isoform X2

    Conserved Domains (2) summary
    pfam11838
    Location:268 → 587
    ERAP1_C; ERAP1-like C-terminal domain
    cl14813
    Location:1 → 193
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2KHK3.3 GenPept UniProtKB/Swiss-Prot:Q2KHK3

Gene LinkOut

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