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Themis3 thymocyte selection associated family member 3 [ Mus musculus (house mouse) ]

Gene ID: 74556, updated on 27-Feb-2024

Summary

Official Symbol
Themis3provided by MGI
Official Full Name
thymocyte selection associated family member 3provided by MGI
Primary source
MGI:MGI:1921806
See related
Ensembl:ENSMUSG00000024105 AllianceGenome:MGI:1921806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130404H23Rik
Summary
Predicted to be involved in T cell receptor signaling pathway. Predicted to be active in cytoplasm and nucleus. Orthologous to human THEMIS3P (thymocyte selection associated family member 3, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 23.6), small intestine adult (RPKM 11.9) and 2 other tissues See more
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Genomic context

Location:
17 E1.1; 17 37.88 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (66861519..66901642, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (66554524..66594647, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43061 Neighboring gene microtubule crosslinking factor 1 Neighboring gene STARR-seq mESC enhancer starr_43062 Neighboring gene STARR-seq mESC enhancer starr_43065 Neighboring gene STARR-seq mESC enhancer starr_43067 Neighboring gene STARR-seq mESC enhancer starr_43070 Neighboring gene VISTA enhancer mm1499 Neighboring gene STARR-seq mESC enhancer starr_43072 Neighboring gene predicted gene 4705 Neighboring gene STARR-seq mESC enhancer starr_43077 Neighboring gene STARR-seq mESC enhancer starr_43079 Neighboring gene predicted gene, 41608 Neighboring gene RAB12, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_43080 Neighboring gene predicted gene, 46576 Neighboring gene VISTA enhancer mm1745 Neighboring gene RIKEN cDNA 1700016K05 gene Neighboring gene protein tyrosine phosphatase receptor type M

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein THEMIS3
Names
thymocyte-expressed molecule involved in selection protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028998.2NP_083274.1  protein THEMIS3

    See identical proteins and their annotated locations for NP_083274.1

    Status: VALIDATED

    Source sequence(s)
    AC122445, CT010496
    Consensus CDS
    CCDS50170.1
    UniProtKB/Swiss-Prot
    Q9CU24
    Related
    ENSMUSP00000024914.3, ENSMUST00000024914.4
    Conserved Domains (1) summary
    pfam12736
    Location:17262
    CABIT; Cell-cycle sustaining, positive selection,

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    66861519..66901642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)