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Nipal3 NIPA-like domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 74552, updated on 21-Apr-2024

Summary

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Official Symbol
Nipal3provided by MGI
Official Full Name
NIPA-like domain containing 3provided by MGI
Primary source
MGI:MGI:1921802
See related
Ensembl:ENSMUSG00000028803 AllianceGenome:MGI:1921802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Npal3; 9130020G22Rik
Summary
Predicted to enable magnesium ion transmembrane transporter activity. Predicted to be involved in magnesium ion transport. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in several structures, including alimentary system; genitourinary system; liver; nasal cavity epithelium; and nervous system. Orthologous to human NIPAL3 (NIPA like domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 17.0), colon adult (RPKM 13.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 67.64 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135173454..135222283, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135442805..135494972, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene noncompact myelin associated protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:134982608-134982761 Neighboring gene regulator of calcineurin 3 Neighboring gene microRNA 700 Neighboring gene STARR-positive B cell enhancer ABC_E9603 Neighboring gene STARR-positive B cell enhancer ABC_E1286 Neighboring gene STARR-positive B cell enhancer mm9_chr4:135050361-135050662 Neighboring gene STARR-seq mESC enhancer starr_11721 Neighboring gene sperm tail PG rich repeat containing 1 Neighboring gene STARR-seq mESC enhancer starr_11724 Neighboring gene grainyhead like transcription factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E6235 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135126769-135126952 Neighboring gene STARR-seq mESC enhancer starr_11727 Neighboring gene predicted gene, 30888 Neighboring gene STARR-seq mESC enhancer starr_11728 Neighboring gene STARR-seq mESC enhancer starr_11730 Neighboring gene RIKEN cDNA 1700029M20 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeted disruption of the mouse Npal3 gene leads to deficits in behavior, increased IgE levels, and impaired lung function. Grzmil P, et al. Cytogenet Genome Res, 2009. PMID 19738379
  2. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  3. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in magnesium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NIPA-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347220.1 → NP_001334149.1  NIPA-like protein 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL627185, AL670720
    Consensus CDS
    CCDS84805.1
    UniProtKB/TrEMBL
    A2A987
    Related
    ENSMUSP00000101482.3, ENSMUST00000105856.9
    Conserved Domains (1) summary
    cl23754
    Location:36 → 330
    EamA; EamA-like transporter family

  2. NM_001361484.1 → NP_001348413.1  NIPA-like protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627185, AL670720
    Consensus CDS
    CCDS18786.1
    UniProtKB/Swiss-Prot
    Q6PG85, Q8BGN5, Q9D2Y2
    Conserved Domains (1) summary
    cl23754
    Location:36 → 330
    EamA; EamA-like transporter family

  3. NM_028995.4 → NP_083271.1  NIPA-like protein 3 isoform 2

    See identical proteins and their annotated locations for NP_083271.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK138843, BY245070, CD774340
    Consensus CDS
    CCDS18786.1
    UniProtKB/Swiss-Prot
    Q6PG85, Q8BGN5, Q9D2Y2
    Related
    ENSMUSP00000099608.4, ENSMUST00000102549.10
    Conserved Domains (1) summary
    cl23754
    Location:36 → 330
    EamA; EamA-like transporter family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135173454..135222283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539230.5 → XP_006539293.1  NIPA-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006539293.1

    UniProtKB/TrEMBL
    A2A987
    Conserved Domains (1) summary
    cl23754
    Location:36 → 330
    EamA; EamA-like transporter family

  2. XM_030253855.2 → XP_030109715.1  NIPA-like protein 3 isoform X4

    Conserved Domains (1) summary
    cl23754
    Location:4 → 165
    EamA; EamA-like transporter family

  3. XM_030253854.1 → XP_030109714.1  NIPA-like protein 3 isoform X3

    Conserved Domains (1) summary
    cl23754
    Location:36 → 330
    EamA; EamA-like transporter family

  4. XM_036164503.1 → XP_036020396.1  NIPA-like protein 3 isoform X5

    Conserved Domains (1) summary
    cl23754
    Location:10 → 165
    EamA; EamA-like transporter family

  5. XM_006539231.2 → XP_006539294.1  NIPA-like protein 3 isoform X3

    Conserved Domains (1) summary
    cl23754
    Location:36 → 330
    EamA; EamA-like transporter family

  6. XM_036164502.1 → XP_036020395.1  NIPA-like protein 3 isoform X2

    Conserved Domains (1) summary
    cl23754
    Location:36 → 330
    EamA; EamA-like transporter family

RNA

  1. XR_003955032.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGN5.1 GenPept UniProtKB/Swiss-Prot:Q8BGN5

Gene LinkOut

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