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Gzf1 GDNF-inducible zinc finger protein 1 [ Mus musculus (house mouse) ]

Gene ID: 74533, updated on 5-Mar-2024

Summary

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Official Symbol
Gzf1provided by MGI
Official Full Name
GDNF-inducible zinc finger protein 1provided by MGI
Primary source
MGI:MGI:1921783
See related
Ensembl:ENSMUSG00000027439 AllianceGenome:MGI:1921783
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mGZF1; Zfp336; 8430437G08Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within branching involved in ureteric bud morphogenesis and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including genitourinary system; limb mesenchyme; liver; lung; and visual system. Orthologous to human GZF1 (GDNF inducible zinc finger protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.1), placenta adult (RPKM 6.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 G3; 2 73.53 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (148521305..148534869)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (148679384..148692949)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 25866 Neighboring gene STARR-positive B cell enhancer ABC_E2052 Neighboring gene STARR-positive B cell enhancer mm9_chr2:148506639-148506940 Neighboring gene NTF2-related export protein 1 Neighboring gene predicted gene, 46771 Neighboring gene N-ethylmaleimide sensitive fusion protein attachment protein beta Neighboring gene predicted gene, 54122 Neighboring gene cystatin-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GZF1 Mutations Expand the Genetic Heterogeneity of Larsen Syndrome. Patel N, et al. Am J Hum Genet, 2017 May 4. PMID 28475863, Free PMC Article
  2. Activation of the GDNF-inducible transcription factor (GIF) gene promoter by glucocorticoid and progesterone. Lee SH, et al. J Steroid Biochem Mol Biol, 2009 May. PMID 19429458
  3. Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis. Fukuda N, et al. J Biol Chem, 2003 Dec 12. PMID 14522971
  4. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Progesterone receptors and glucocorticoid receptors, but not estrogen receptors, up-regulate transcription from the GDNF-inducible zinc finger protein promoter
    Title: Activation of the GDNF-inducible transcription factor (GIF) gene promoter by glucocorticoid and progesterone.
  2. induction of GZF1 expression via the is required for renal branching morphogenesis
    Title: Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GDNF-inducible zinc finger protein 1
Names
zinc finger protein 336

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355689.1 → NP_001342618.1  GDNF-inducible zinc finger protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL928638
    Consensus CDS
    CCDS16841.1
    UniProtKB/Swiss-Prot
    Q4VBD9, Q8BGY0
    UniProtKB/TrEMBL
    Q9CX96
    Conserved Domains (5) summary
    COG5048
    Location:410 → 538
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:519 → 539
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:317 → 337
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18211
    Location:6 → 133
    BTB_POZ_ZBTB23_GZF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1)
    pfam13465
    Location:531 → 556
    zf-H2C2_2; Zinc-finger double domain

  2. NM_028986.3 → NP_083262.1  GDNF-inducible zinc finger protein 1

    See identical proteins and their annotated locations for NP_083262.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK052820, BC096015, BY123697
    Consensus CDS
    CCDS16841.1
    UniProtKB/Swiss-Prot
    Q4VBD9, Q8BGY0
    UniProtKB/TrEMBL
    Q9CX96
    Related
    ENSMUSP00000028928.8, ENSMUST00000028928.8
    Conserved Domains (5) summary
    COG5048
    Location:410 → 538
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:519 → 539
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:317 → 337
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18211
    Location:6 → 133
    BTB_POZ_ZBTB23_GZF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1)
    pfam13465
    Location:531 → 556
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    148521305..148534869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162645.1 → XP_036018538.1  GDNF-inducible zinc finger protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q4VBD9, Q8BGY0
    UniProtKB/TrEMBL
    Q9CX96
    Conserved Domains (5) summary
    COG5048
    Location:410 → 538
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:519 → 539
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:317 → 337
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18211
    Location:6 → 133
    BTB_POZ_ZBTB23_GZF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1)
    pfam13465
    Location:531 → 556
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006500305.5 → XP_006500368.1  GDNF-inducible zinc finger protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006500368.1

    UniProtKB/Swiss-Prot
    Q4VBD9, Q8BGY0
    UniProtKB/TrEMBL
    Q9CX96
    Conserved Domains (5) summary
    COG5048
    Location:410 → 538
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:519 → 539
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:317 → 337
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18211
    Location:6 → 133
    BTB_POZ_ZBTB23_GZF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1)
    pfam13465
    Location:531 → 556
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_004940758.1 RNA Sequence

  2. XR_003953729.2 RNA Sequence

  3. XR_003953730.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4VBD9.2 GenPept UniProtKB/Swiss-Prot:Q4VBD9

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