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Ppp4r4 protein phosphatase 4, regulatory subunit 4 [ Mus musculus (house mouse) ]

Gene ID: 74521, updated on 5-Mar-2024

Summary

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Official Symbol
Ppp4r4provided by MGI
Official Full Name
protein phosphatase 4, regulatory subunit 4provided by MGI
Primary source
MGI:MGI:1921771
See related
Ensembl:ENSMUSG00000021209 AllianceGenome:MGI:1921771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1622; 8430415E04Rik
Summary
Predicted to enable protein phosphatase regulator activity. Acts upstream of or within blastocyst hatching. Predicted to be located in cytoplasm. Predicted to be part of protein serine/threonine phosphatase complex. Predicted to be active in cytosol. Is expressed in early conceptus; secondary oocyte; and telencephalon mantle layer. Orthologous to human PPP4R4 (protein phosphatase 4 regulatory subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 4.9), frontal lobe adult (RPKM 4.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 E; 12 52.95 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103498509..103580098)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103532250..103613839)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2393 Neighboring gene STARR-seq mESC enhancer starr_33125 Neighboring gene STARR-positive B cell enhancer ABC_E2394 Neighboring gene interferon, alpha-inducible protein 27 like 2A Neighboring gene interferon, alpha-inducible protein 27 Neighboring gene predicted gene, 53759 Neighboring gene interferon, alpha-inducible protein 27 like 2B Neighboring gene STARR-positive B cell enhancer ABC_E7175 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 Neighboring gene crumbs homolog 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4. Chen GI, et al. J Biol Chem, 2008 Oct 24. PMID 18715871, Free PMC Article
  2. Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Cui W, et al. Sci Rep, 2016 Nov 21. PMID 27869233, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of protein serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of protein serine/threonine phosphatase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein serine/threonine phosphatase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 4 regulatory subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028980.3 → NP_083256.2  serine/threonine-protein phosphatase 4 regulatory subunit 4

    See identical proteins and their annotated locations for NP_083256.2

    Status: VALIDATED

    Source sequence(s)
    AK029499, BB307572, BC111887
    Consensus CDS
    CCDS36532.1
    UniProtKB/Swiss-Prot
    E9QKU6, Q14CI7, Q14DT1, Q69ZE5, Q8C0Y0, Q9CRR0
    Related
    ENSMUSP00000021631.6, ENSMUST00000021631.12
    Conserved Domains (2) summary
    PTZ00108
    Location:650 → 875
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    sd00044
    Location:214 → 244
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    103498509..103580098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244194.4 → XP_011242496.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X5

    See identical proteins and their annotated locations for XP_011242496.1

    UniProtKB/Swiss-Prot
    Q8C0Y0
    Related
    ENSMUSP00000139786.2, ENSMUST00000189871.7
    Conserved Domains (1) summary
    sd00044
    Location:214 → 244
    HEAT; HEAT repeat [structural motif]

  2. XM_006516308.2 → XP_006516371.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1

    Conserved Domains (2) summary
    PTZ00108
    Location:655 → 880
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    sd00044
    Location:219 → 249
    HEAT; HEAT repeat [structural motif]

  3. XM_006516314.4 → XP_006516377.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X3

    Conserved Domains (1) summary
    sd00044
    Location:219 → 249
    HEAT; HEAT repeat [structural motif]

  4. XM_006516315.4 → XP_006516378.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X4

    Conserved Domains (1) summary
    sd00044
    Location:219 → 249
    HEAT; HEAT repeat [structural motif]

  5. XM_030246960.1 → XP_030102820.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2

    Conserved Domains (2) summary
    PTZ00108
    Location:541 → 766
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    sd00044
    Location:105 → 135
    HEAT; HEAT repeat [structural motif]

  6. XM_030246961.1 → XP_030102821.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2

    Conserved Domains (2) summary
    PTZ00108
    Location:541 → 766
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    sd00044
    Location:105 → 135
    HEAT; HEAT repeat [structural motif]

  7. XM_030246962.1 → XP_030102822.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2

    Related
    ENSMUSP00000140874.2, ENSMUST00000187155.7
    Conserved Domains (2) summary
    PTZ00108
    Location:541 → 766
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    sd00044
    Location:105 → 135
    HEAT; HEAT repeat [structural motif]

RNA

  1. XR_003950088.1 RNA Sequence

  2. XR_001780496.2 RNA Sequence

  3. XR_381552.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0Y0.2 GenPept UniProtKB/Swiss-Prot:Q8C0Y0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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