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Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 [ Mus musculus (house mouse) ]

Gene ID: 74519, updated on 3-Apr-2024

Summary

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Official Symbol
Cyp2j9provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily j, polypeptide 9provided by MGI
Primary source
MGI:MGI:1921769
See related
Ensembl:ENSMUSG00000015224 AllianceGenome:MGI:1921769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
8430417E17Rik
Summary
Predicted to enable heme binding activity; isomerase activity; and monooxygenase activity. Predicted to be involved in epoxygenase P450 pathway; linoleic acid metabolic process; and xenobiotic metabolic process. Located in endoplasmic reticulum. Is expressed in alimentary system; ductus arteriosus; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 8.9), cortex adult (RPKM 7.7) and 20 other tissues See more
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Genomic context

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Location:
4 C5; 4 44.66 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (96456661..96480748, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (96568424..96592523, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10825 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 8 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 6 Neighboring gene STARR-seq mESC enhancer starr_10826 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 5 Neighboring gene predicted gene 12695

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain. Qu W, et al. J Biol Chem, 2001 Jul 6. PMID 11328810
  2. EDHF function in the ductus arteriosus: evidence against involvement of epoxyeicosatrienoic acids and 12S-hydroxyeicosatetraenoic acid. Baragatti B, et al. Am J Physiol Heart Circ Physiol, 2009 Dec. PMID 19801493, Free PMC Article
  3. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC141274

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arachidonic acid 11,12-epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonic acid 14,15-epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonic acid epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables linoleic acid epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in epoxygenase P450 pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in icosanoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in linoleic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome P450, family 2, subfamily j, polypeptide 9
Names
cytochrome P450, 2j9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419233.1 → NP_001406162.1  cytochrome P450, family 2, subfamily j, polypeptide 9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL683816
    Related
    ENSMUST00000126509.2

  2. NM_001419234.1 → NP_001406163.1  cytochrome P450, family 2, subfamily j, polypeptide 9 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL683816

  3. NM_001419236.1 → NP_001406165.1  cytochrome P450, family 2, subfamily j, polypeptide 9 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL683816

  4. NM_028979.3 → NP_083255.1  cytochrome P450, family 2, subfamily j, polypeptide 9 isoform 1

    See identical proteins and their annotated locations for NP_083255.1

    Status: VALIDATED

    Source sequence(s)
    AL683816
    Consensus CDS
    CCDS18370.1
    UniProtKB/TrEMBL
    Q924D1, Q9CRQ9
    Related
    ENSMUSP00000050464.9, ENSMUST00000055693.9
    Conserved Domains (1) summary
    pfam00067
    Location:44 → 497
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    96456661..96480748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253853.2 → XP_030109713.1  cytochrome P450, family 2, subfamily j, polypeptide 9 isoform X1

    UniProtKB/TrEMBL
    Q9CRQ9
    Conserved Domains (1) summary
    pfam00067
    Location:32 → 440
    p450; Cytochrome P450
Nucleotide Protein Strain
Heading Accession and Version

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