Lrrc17 leucine rich repeat containing 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrrc17provided by MGI
Official Full Name: leucine rich repeat containing 17provided by MGI
Primary source: MGI:MGI:1921761
See related: Ensembl:ENSMUSG00000039883 AllianceGenome:MGI:1921761
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 37kDa; P37nb; 4833425M04Rik; 6130400C22Rik
Summary: Involved in bone marrow development and negative regulation of osteoclast differentiation. Located in extracellular space. Is expressed in early conceptus and ovary. Orthologous to human LRRC17 (leucine rich repeat containing 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in limb E14.5 (RPKM 31.9), subcutaneous fat pad adult (RPKM 13.0) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A3; 5 9.89 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (21748525..21780909)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (21543527..21575911)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss.
Title: LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss.
These results demonstrated a novel inhibitory activity of LRRc17 in RANKL-induced osteoclastogenesis.
Title: Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

Lrrc17 (e-PCR), detects polymorphism
- UniSTS:526922

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in bone marrow development	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ossification	IEA Inferred from Electronic Annotation more info
NOT involved_in osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in osteoblast proliferation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: leucine-rich repeat-containing protein 17

Names: 37 kDa leucine-rich repeat (LRR) protein; leucine-rich repeat (LRR) protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028977.1 → NP_083253.1 leucine-rich repeat-containing protein 17 precursor

See identical proteins and their annotated locations for NP_083253.1

Status: VALIDATED

Source sequence(s)

AK018071, CD741871, CF914556

Consensus CDS

CCDS51428.1

UniProtKB/Swiss-Prot

Q9CXD9

Related

ENSMUSP00000038569.5, ENSMUST00000035651.6

Conserved Domains (5) summary

cd00116
Location:270 → 352

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:85 → 108

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:296 → 334

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:274 → 330

LRR_8; Leucine rich repeat

cl15307
Location:165 → 201

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain