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Lrrc15 leucine rich repeat containing 15 [ Mus musculus (house mouse) ]

Gene ID: 74488, updated on 5-Mar-2024

Summary

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Official Symbol
Lrrc15provided by MGI
Official Full Name
leucine rich repeat containing 15provided by MGI
Primary source
MGI:MGI:1921738
See related
Ensembl:ENSMUSG00000052316 AllianceGenome:MGI:1921738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LIB; 5430427N11Rik
Summary
Predicted to enable collagen binding activity; fibronectin binding activity; and laminin binding activity. Predicted to be involved in negative regulation of protein localization to plasma membrane; positive regulation of cell migration; and receptor-mediated virion attachment to host cell. Predicted to be located in cell surface. Predicted to be active in extracellular matrix and extracellular space. Predicted to colocalize with collagen-containing extracellular matrix. Is expressed in several structures, including gonad; incisor; skin; submandibular gland; and trunk. Orthologous to human LRRC15 (leucine rich repeat containing 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 6.0), mammary gland adult (RPKM 2.2) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Lrrc15 in Genome Data Viewer
Location:
16 B2; 16 21.23 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (30088120..30102072, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (30269302..30283254, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5535 Neighboring gene predicted gene, 33330 Neighboring gene carboxypeptidase N, polypeptide 2 Neighboring gene STARR-seq mESC enhancer starr_40574 Neighboring gene ATPase type 13A3 Neighboring gene glycoprotein 5 platelet Neighboring gene STARR-positive B cell enhancer mm9_chr16:30374407-30374708

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LRRC15(+) myofibroblasts dictate the stromal setpoint to suppress tumour immunity. Krishnamurty AT, et al. Nature, 2022 Nov. PMID 36171287, Free PMC Article
  2. LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation. Wang Y, et al. Stem Cell Res Ther, 2018 Mar 9. PMID 29523191, Free PMC Article
  3. Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis. Singh P, et al. Sci Rep, 2021 Oct 26. PMID 34702854, Free PMC Article
  4. Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein. Reynolds PA, et al. Genes Dev, 2003 Sep 1. PMID 12923058, Free PMC Article
  5. Mitochondrial retention of Opa1 is required for mouse embryogenesis. Moore BA, et al. Mamm Genome, 2010 Aug. PMID 20652258

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LRRC15(+) myofibroblasts dictate the stromal setpoint to suppress tumour immunity.
    Title: LRRC15(+) myofibroblasts dictate the stromal setpoint to suppress tumour immunity.
  2. Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis.
    Title: Transcriptomic and epigenomic analyses uncovered Lrrc15 as a contributing factor to cartilage damage in osteoarthritis.
  3. LRRC15 is an essential regulator for osteogenesis of mesenchymal stem cells through modulating p65 cytoplasmic/nuclear translocation.
    Title: LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding ISO
Inferred from Sequence Orthology
more info
  
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
  
enables laminin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor-mediated virion attachment to host cell ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028973.2 → NP_083249.1  leucine-rich repeat-containing protein 15 precursor

    See identical proteins and their annotated locations for NP_083249.1

    Status: VALIDATED

    Source sequence(s)
    AK017350, BC050245, BX522800
    Consensus CDS
    CCDS28099.1
    UniProtKB/Swiss-Prot
    Q80X72
    Related
    ENSMUSP00000066777.8, ENSMUST00000064606.8
    Conserved Domains (3) summary
    smart00082
    Location:423 → 462
    LRRCT; Leucine rich repeat C-terminal domain
    PLN00113
    Location:82 → 401
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:127 → 150
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    30088120..30102072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160172.1 → XP_036016065.1  leucine-rich repeat-containing protein 15 isoform X1

    UniProtKB/Swiss-Prot
    Q80X72
    Conserved Domains (3) summary
    smart00082
    Location:423 → 462
    LRRCT; Leucine rich repeat C-terminal domain
    PLN00113
    Location:82 → 401
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:127 → 150
    LRR_RI; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80X72.1 GenPept UniProtKB/Swiss-Prot:Q80X72

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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