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Ifitm7 interferon induced transmembrane protein 7 [ Mus musculus (house mouse) ]

Gene ID: 74482, updated on 11-Apr-2024

Summary

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Official Symbol
Ifitm7provided by MGI
Official Full Name
interferon induced transmembrane protein 7provided by MGI
Primary source
MGI:MGI:1921732
See related
AllianceGenome:MGI:1921732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mil4; 4933438K12Rik
Summary
Predicted to be involved in several processes, including cellular response to interferon-beta; defense response to other organism; and positive regulation of osteoblast differentiation. Predicted to be located in early endosome membrane; late endosome membrane; and lysosomal membrane. Predicted to be active in plasma membrane. Is expressed in alimentary system; epidermis; liver; and testis. Human ortholog(s) of this gene implicated in COVID-19; adenosquamous gallbladder carcinoma; and gallbladder adenocarcinoma. Orthologous to human IFITM1 (interferon induced transmembrane protein 1); IFITM2 (interferon induced transmembrane protein 2); and IFITM3 (interferon induced transmembrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 36.3), CNS E18 (RPKM 10.7) and 5 other tissues See more
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Genomic context

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See Ifitm7 in Genome Data Viewer
Location:
16 A1; 16 9.66 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (13799566..13804731, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (13981702..13986867, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene pyridoxal-dependent decarboxylase domain containing 1 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40163 Neighboring gene STARR-positive B cell enhancer ABC_E8619 Neighboring gene Mpv17 transgene, kidney disease mutant-like Neighboring gene STARR-seq mESC enhancer starr_40164 Neighboring gene laminin, gamma 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40165 Neighboring gene STARR-seq mESC enhancer starr_40166 Neighboring gene STARR-seq mESC enhancer starr_40168 Neighboring gene STARR-seq mESC enhancer starr_40169 Neighboring gene STARR-seq mESC enhancer starr_40170 Neighboring gene bMERB domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_40172 Neighboring gene aldo-keto reductase family 1, member B8 pseudogene Neighboring gene high mobility group nucleosome-binding domain-containing protein 5-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Developmentally regulated expression of mil-1 and mil-2, mouse interferon-induced transmembrane protein like genes, during formation and differentiation of primordial germ cells. Tanaka SS, et al. Mech Dev, 2002 Dec. PMID 14516695
  2. Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster. Lange UC, et al. Mol Cell Biol, 2008 Aug. PMID 18505827, Free PMC Article
  3. The fragilis interferon-inducible gene family of transmembrane proteins is associated with germ cell specification in mice. Lange UC, et al. BMC Dev Biol, 2003 Mar 19. PMID 12659663, Free PMC Article
  4. The dispanins: a novel gene family of ancient origin that contains 14 human members. Sällman Almén M, et al. PLoS One, 2012. PMID 22363774, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral entry into host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in response to interferon-alpha IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
  
involved_in response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to interferon-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interferon induced transmembrane protein 7
Names
interferon induced transmembrane protein 4 like
interferon induced transmembrane protein like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270718.1 → NP_001257647.1  interferon induced transmembrane protein 7

    See identical proteins and their annotated locations for NP_001257647.1

    Status: VALIDATED

    Source sequence(s)
    AK076846
    UniProtKB/TrEMBL
    Q8BVR2, Q9D3R8
    Conserved Domains (1) summary
    pfam04505
    Location:28 → 98
    CD225; Interferon-induced transmembrane protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    13799566..13804731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001110161.1: Suppressed sequence

    Description
    NM_001110161.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein

  2. NM_028968.2: Suppressed sequence

    Description
    NM_028968.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which includes a large amount of intronic and repetitive sequence.
Nucleotide Protein Strain
Heading Accession and Version

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