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Snx11 sorting nexin 11 [ Mus musculus (house mouse) ]

Gene ID: 74479, updated on 5-Mar-2024

Summary

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Official Symbol
Snx11provided by MGI
Official Full Name
sorting nexin 11provided by MGI
Primary source
MGI:MGI:1921729
See related
Ensembl:ENSMUSG00000020876 AllianceGenome:MGI:1921729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933439F10Rik; A930041K09Rik
Summary
Predicted to enable phosphatidylinositol phosphate binding activity. Predicted to be involved in vesicle organization. Predicted to act upstream of or within protein transport. Predicted to be located in endosome. Is expressed in central nervous system and olfactory epithelium. Orthologous to human SNX11 (sorting nexin 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 11.2), whole brain E14.5 (RPKM 11.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Snx11 in Genome Data Viewer
Location:
11 D; 11 60.1 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96658372..96668538, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96767546..96777712, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11529 Neighboring gene src family associated phosphoprotein 1 Neighboring gene predicted gene, 38960 Neighboring gene STARR-seq mESC enhancer starr_30554 Neighboring gene STARR-seq mESC enhancer starr_30556 Neighboring gene STARR-seq mESC enhancer starr_30559 Neighboring gene STARR-seq mESC enhancer starr_30560 Neighboring gene STARR-positive B cell enhancer ABC_E1146 Neighboring gene STARR-seq mESC enhancer starr_30562 Neighboring gene STARR-seq mESC enhancer starr_30564 Neighboring gene STARR-seq mESC enhancer starr_30565 Neighboring gene STARR-positive B cell enhancer ABC_E9144 Neighboring gene STARR-positive B cell enhancer ABC_E9371 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene Neighboring gene chromobox 1 Neighboring gene nuclear factor, erythroid derived 2,-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sorting nexin 11 knockout mice exhibit enhanced thermosensing behaviour. Huang HL, et al. Genes Brain Behav, 2020 Jul. PMID 31730264
  2. Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Joyal JS, et al. Nat Med, 2014 Oct. PMID 25216639
  3. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sorting nexin 11 knockout mice exhibit enhanced thermosensing behaviour.
    Title: Sorting nexin 11 knockout mice exhibit enhanced thermosensing behaviour.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sorting nexin-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163389.1 → NP_001156861.1  sorting nexin-11

    See identical proteins and their annotated locations for NP_001156861.1

    Status: VALIDATED

    Source sequence(s)
    AK042409, AL607127, AV350384
    Consensus CDS
    CCDS25302.1
    UniProtKB/Swiss-Prot
    Q3V3A6, Q91WL6
    UniProtKB/TrEMBL
    Q9CUA3
    Related
    ENSMUSP00000103288.4, ENSMUST00000107661.10
    Conserved Domains (1) summary
    cd06898
    Location:18 → 129
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  2. NM_028965.4 → NP_083241.1  sorting nexin-11

    See identical proteins and their annotated locations for NP_083241.1

    Status: VALIDATED

    Source sequence(s)
    AK076332, AL607127, AV350384
    Consensus CDS
    CCDS25302.1
    UniProtKB/Swiss-Prot
    Q3V3A6, Q91WL6
    UniProtKB/TrEMBL
    Q9CUA3
    Related
    ENSMUSP00000021246.3, ENSMUST00000021246.9
    Conserved Domains (1) summary
    cd06898
    Location:18 → 129
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    96658372..96668538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249289.3 → XP_011247591.1  sorting nexin-11 isoform X1

    See identical proteins and their annotated locations for XP_011247591.1

    UniProtKB/Swiss-Prot
    Q3V3A6, Q91WL6
    UniProtKB/TrEMBL
    Q9CUA3
    Conserved Domains (1) summary
    cd06898
    Location:18 → 129
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

  2. XM_006534375.4 → XP_006534438.1  sorting nexin-11 isoform X1

    See identical proteins and their annotated locations for XP_006534438.1

    UniProtKB/Swiss-Prot
    Q3V3A6, Q91WL6
    UniProtKB/TrEMBL
    Q9CUA3
    Conserved Domains (1) summary
    cd06898
    Location:18 → 129
    PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WL6.1 GenPept UniProtKB/Swiss-Prot:Q91WL6

Gene LinkOut

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