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Cep72 centrosomal protein 72 [ Mus musculus (house mouse) ]

Gene ID: 74470, updated on 5-Mar-2024

Summary

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Official Symbol
Cep72provided by MGI
Official Full Name
centrosomal protein 72provided by MGI
Primary source
MGI:MGI:1921720
See related
Ensembl:ENSMUSG00000021572 AllianceGenome:MGI:1921720
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610029E11Rik; 4933440J22Rik
Summary
Enables identical protein binding activity. Predicted to be involved in gamma-tubulin complex localization; microtubule cytoskeleton organization; and regulation of protein localization to centrosome. Located in centriolar satellite. Orthologous to human CEP72 (centrosomal protein 72). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 18.9), CNS E11.5 (RPKM 3.5) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 C1; 13 40.15 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74184351..74210439, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (74036495..74062319, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15912 Neighboring gene tubulin polymerization promoting protein Neighboring gene integrin linked kinase pseudogene Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 3 Neighboring gene predicted gene, 41003 Neighboring gene exocyst complex component 3 Neighboring gene STARR-positive B cell enhancer ABC_E8534

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of Cep72 affects the morphology of spermatozoa in mice. Chen Z, et al. Front Physiol, 2022. PMID 36277211, Free PMC Article
  2. The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium. Stowe TR, et al. Mol Biol Cell, 2012 Sep. PMID 22767577, Free PMC Article
  3. Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes. Hall EA, et al. PLoS Genet, 2013. PMID 24415959, Free PMC Article
  4. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in gamma-tubulin complex localization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization to centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein of 72 kDa
Names
centrosomal protein 72 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028959.3 → NP_083235.3  centrosomal protein of 72 kDa

    See identical proteins and their annotated locations for NP_083235.3

    Status: VALIDATED

    Source sequence(s)
    AK034892, CJ079657
    Consensus CDS
    CCDS26639.1
    UniProtKB/Swiss-Prot
    E9QQ95, Q3TU12, Q497H8, Q69ZH7, Q8BM53, Q9D0B7, Q9D3R3
    Related
    ENSMUSP00000037788.7, ENSMUST00000036456.8
    Conserved Domains (4) summary
    smart00446
    Location:117 → 134
    LRRcap; occurring C-terminal to leucine-rich repeats
    sd00031
    Location:55 → 76
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:53 → 93
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:28 → 85
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    74184351..74210439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517423.5 → XP_006517486.1  centrosomal protein of 72 kDa isoform X4

    UniProtKB/TrEMBL
    A0A1Y7VJU1
    Related
    ENSMUSP00000152641.2, ENSMUST00000222609.2
    Conserved Domains (3) summary
    TIGR04211
    Location:395 → 541
    SH3_and_anchor; SH3 domain protein
    sd00031
    Location:55 → 76
    LRR_1; leucine-rich repeat [structural motif]
    pfam14580
    Location:51 → 150
    LRR_9; Leucine-rich repeat

  2. XM_006517422.5 → XP_006517485.1  centrosomal protein of 72 kDa isoform X3

    Conserved Domains (3) summary
    TIGR04211
    Location:416 → 562
    SH3_and_anchor; SH3 domain protein
    sd00031
    Location:55 → 76
    LRR_1; leucine-rich repeat [structural motif]
    pfam14580
    Location:51 → 150
    LRR_9; Leucine-rich repeat

  3. XM_011244576.4 → XP_011242878.1  centrosomal protein of 72 kDa isoform X1

    Conserved Domains (3) summary
    TIGR04211
    Location:475 → 621
    SH3_and_anchor; SH3 domain protein
    sd00031
    Location:55 → 76
    LRR_1; leucine-rich repeat [structural motif]
    pfam14580
    Location:51 → 150
    LRR_9; Leucine-rich repeat

  4. XM_030247437.2 → XP_030103297.1  centrosomal protein of 72 kDa isoform X2

    Conserved Domains (4) summary
    TIGR04211
    Location:426 → 572
    SH3_and_anchor; SH3 domain protein
    sd00031
    Location:6 → 27
    LRR_1; leucine-rich repeat [structural motif]
    sd00035
    Location:55 → 80
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam14580
    Location:2 → 101
    LRR_9; Leucine-rich repeat

  5. XM_030247438.2 → XP_030103298.1  centrosomal protein of 72 kDa isoform X7

    Conserved Domains (3) summary
    TIGR04211
    Location:395 → 541
    SH3_and_anchor; SH3 domain protein
    sd00031
    Location:55 → 76
    LRR_1; leucine-rich repeat [structural motif]
    pfam14580
    Location:51 → 150
    LRR_9; Leucine-rich repeat

  6. XM_006517424.5 → XP_006517487.1  centrosomal protein of 72 kDa isoform X5

    UniProtKB/TrEMBL
    A0A1Y7VJU1
    Conserved Domains (3) summary
    sd00031
    Location:55 → 76
    LRR_1; leucine-rich repeat [structural motif]
    pfam10498
    Location:446 → 557
    IFT57; Intra-flagellar transport protein 57
    pfam14580
    Location:51 → 150
    LRR_9; Leucine-rich repeat

  7. XM_006517425.5 → XP_006517488.1  centrosomal protein of 72 kDa isoform X6

    UniProtKB/TrEMBL
    A0A1Y7VJU1
    Conserved Domains (3) summary
    sd00031
    Location:55 → 76
    LRR_1; leucine-rich repeat [structural motif]
    pfam10498
    Location:446 → 555
    IFT57; Intra-flagellar transport protein 57
    pfam14580
    Location:51 → 150
    LRR_9; Leucine-rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3R3.3 GenPept UniProtKB/Swiss-Prot:Q9D3R3

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