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Pgs1 phosphatidylglycerophosphate synthase 1 [ Mus musculus (house mouse) ]

Gene ID: 74451, updated on 11-Apr-2024

Summary

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Official Symbol
Pgs1provided by MGI
Official Full Name
phosphatidylglycerophosphate synthase 1provided by MGI
Primary source
MGI:MGI:1921701
See related
Ensembl:ENSMUSG00000017715 AllianceGenome:MGI:1921701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SAF; 2610019F11Rik; 4933424M23Rik
Summary
Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity. Predicted to be involved in cardiolipin biosynthetic process. Predicted to act upstream of or within phospholipid biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; lung; nervous system; and skin. Orthologous to human PGS1 (phosphatidylglycerophosphate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 69.2), lung adult (RPKM 38.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 82.96 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117876505..117914837)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117986297..118024011)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5307 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117733294-117733546 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117733656-117733839 Neighboring gene predicted gene 11725 Neighboring gene threonine aldolase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117774097-117774206 Neighboring gene STARR-seq mESC enhancer starr_31285 Neighboring gene STARR-positive B cell enhancer ABC_E8474 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117813554-117813821 Neighboring gene STARR-positive B cell enhancer ABC_E5308 Neighboring gene STARR-seq mESC enhancer starr_31288 Neighboring gene STARR-positive B cell enhancer ABC_E7103 Neighboring gene suppressor of cytokine signaling 3 Neighboring gene STARR-seq mESC enhancer starr_31291 Neighboring gene microRNA 6933 Neighboring gene STARR-positive B cell enhancer ABC_E7104 Neighboring gene STARR-seq mESC enhancer starr_31293 Neighboring gene STARR-seq mESC enhancer starr_31294 Neighboring gene dynein, axonemal, heavy chain 17 Neighboring gene STARR-seq mESC enhancer starr_31295 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117947366-117947549 Neighboring gene STARR-positive B cell enhancer ABC_E1438 Neighboring gene STARR-positive B cell enhancer ABC_E9849 Neighboring gene predicted gene 11738 Neighboring gene predicted gene, 38514

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cardiolipin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
Names
PGP synthase 1
silencer-associated factor
NP_598518.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133757.2 → NP_598518.1  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

    See identical proteins and their annotated locations for NP_598518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer protein-coding transcript.
    Source sequence(s)
    AK049359
    Consensus CDS
    CCDS25698.1
    UniProtKB/Swiss-Prot
    Q8BHF7, Q8QZT9, Q8R4R7
    UniProtKB/TrEMBL
    B9EKS7, F8WI04
    Related
    ENSMUSP00000121973.2, ENSMUST00000132676.8
    Conserved Domains (2) summary
    cd09135
    Location:93 → 266
    PLDc_PGS1_euk_1; Catalytic domain, repeat 1, of eukaryotic PhosphatidylGlycerophosphate Synthases
    cd09137
    Location:346 → 505
    PLDc_PGS1_euk_2; Catalytic domain, repeat 2, of eukaryotic phosphatidylglycerophosphate synthases

RNA

  1. NR_151726.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK046174, AK049359, AK163967, AW045732
    Related
    ENSMUST00000017859.10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    117876505..117914837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_388542.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHF7.1 GenPept UniProtKB/Swiss-Prot:Q8BHF7

Gene LinkOut

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