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Cmip c-Maf inducing protein [ Mus musculus (house mouse) ]

Gene ID: 74440, updated on 5-Mar-2024

Summary

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Official Symbol
Cmipprovided by MGI
Official Full Name
c-Maf inducing proteinprovided by MGI
Primary source
MGI:MGI:1921690
See related
Ensembl:ENSMUSG00000034390 AllianceGenome:MGI:1921690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933407C03Rik; 5830471E12Rik
Summary
Acts upstream of or within in utero embryonic development. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol and nucleoplasm. Orthologous to human CMIP (c-Maf inducing protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 37.9), whole brain E14.5 (RPKM 37.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 63.87 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (117983758..118188245)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (117257019..117461506)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22807 Neighboring gene STARR-positive B cell enhancer ABC_E8266 Neighboring gene beta-carotene oxygenase 1 Neighboring gene STARR-positive B cell enhancer ABC_E2275 Neighboring gene STARR-positive B cell enhancer mm9_chr8:119748493-119748794 Neighboring gene giant axonal neuropathy Neighboring gene STARR-seq mESC enhancer starr_22810 Neighboring gene STARR-seq mESC enhancer starr_22812 Neighboring gene STARR-seq mESC enhancer starr_22816 Neighboring gene predicted gene, 51554 Neighboring gene STARR-seq mESC enhancer starr_22817 Neighboring gene predicted gene, 39260 Neighboring gene microRNA 7077 Neighboring gene microRNA 7078 Neighboring gene STARR-positive B cell enhancer ABC_E11399 Neighboring gene phospholipase C, gamma 2 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibition of nephrin activation by c-mip through Csk-Cbp-Fyn axis plays a critical role in Angiotensin II-induced podocyte damage. Yu L, et al. Cell Signal, 2013 Mar. PMID 23200848
  2. CMIP is a negative regulator of T cell signaling. Oniszczuk J, et al. Cell Mol Immunol, 2020 Oct. PMID 31395948, Free PMC Article
  3. c-mip down-regulates NF-κB activity and promotes apoptosis in podocytes. Ory V, et al. Am J Pathol, 2012 Jun. PMID 22507836
  4. Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis. Lee J, et al. Exp Mol Med, 2023 Jan. PMID 36609599, Free PMC Article
  5. Repression of CMIP transcription by WT1 is relevant to podocyte health. Moktefi A, et al. Kidney Int, 2016 Dec. PMID 27650733

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Ppargamma-CD36 axis.
    Title: Dnmt1/Tet2-mediated changes in Cmip methylation regulate the development of nonalcoholic fatty liver disease by controlling the Gbp2-Pparγ-CD36 axis.
  2. CMIP is a negative regulator of T cell signaling.
    Title: CMIP is a negative regulator of T cell signaling.
  3. Unlike the human CMIP gene, only one Wt1 response element was identified in the mouse Cmip proximal promoter located at position -217/-206.
    Title: Repression of CMIP transcription by WT1 is relevant to podocyte health.
  4. the c-mip protein is involve in regulating nephrin phosphorylation through Csk-Cbp/PAG-Fyn signaling pathway.
    Title: Inhibition of nephrin activation by c-mip through Csk-Cbp-Fyn axis plays a critical role in Angiotensin II-induced podocyte damage.
  5. Expression of Cmip in the mouse hippocampus is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase).
    Title: A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C-Maf-inducing protein
Names
c-Mip

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163262.1 → NP_001156734.1  C-Maf-inducing protein isoform 1

    See identical proteins and their annotated locations for NP_001156734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC118207, AC121116, AK016712, AK165728, BX514237, BY243950, BY792820, CA552751
    Consensus CDS
    CCDS52680.1
    UniProtKB/Swiss-Prot
    Q69ZD2, Q8C3N2, Q8K148, Q9D486
    UniProtKB/TrEMBL
    B2RY70
    Related
    ENSMUSP00000130264.2, ENSMUST00000166750.9
    Conserved Domains (3) summary
    cd09293
    Location:594 → 768
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:664 → 687
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00169
    Location:71 → 157
    PH; PH domain

  2. NM_028941.1 → NP_083217.1  C-Maf-inducing protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC118207, AK016712, AK165728, BX514237, BY243950, CA552751
    Consensus CDS
    CCDS52681.1
    UniProtKB/TrEMBL
    B2RY70
    Related
    ENSMUSP00000092795.5, ENSMUST00000095172.6
    Conserved Domains (2) summary
    cd09293
    Location:506 → 680
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:576 → 599
    LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    117983758..118188245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531434.4 → XP_006531497.1  C-Maf-inducing protein isoform X2

    UniProtKB/TrEMBL
    B2RY70
    Conserved Domains (2) summary
    cd09293
    Location:518 → 692
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:588 → 611
    LRR_AMN1; leucine-rich repeat [structural motif]

  2. XM_011248527.3 → XP_011246829.3  C-Maf-inducing protein isoform X1

    UniProtKB/TrEMBL
    B2RY70
    Conserved Domains (2) summary
    cd09293
    Location:546 → 685
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:581 → 604
    LRR_AMN1; leucine-rich repeat [structural motif]

  3. XM_006531436.2 → XP_006531499.1  C-Maf-inducing protein isoform X4

    Conserved Domains (2) summary
    cd09293
    Location:442 → 581
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:477 → 500
    LRR_AMN1; leucine-rich repeat [structural motif]

  4. XM_006531435.3 → XP_006531498.1  C-Maf-inducing protein isoform X3

    See identical proteins and their annotated locations for XP_006531498.1

    UniProtKB/TrEMBL
    B2RY70
    Conserved Domains (2) summary
    cd09293
    Location:476 → 615
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:511 → 534
    LRR_AMN1; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D486.3 GenPept UniProtKB/Swiss-Prot:Q9D486

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