U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tmc5 transmembrane channel-like gene family 5 [ Mus musculus (house mouse) ]

Gene ID: 74424, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Tmc5provided by MGI
Official Full Name
transmembrane channel-like gene family 5provided by MGI
Primary source
MGI:MGI:1921674
See related
Ensembl:ENSMUSG00000030650 AllianceGenome:MGI:1921674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4932443L08Rik
Summary
Predicted to enable mechanosensitive ion channel activity. Predicted to act upstream of or within ion transport. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Is expressed in sensory organ and skeleton. Orthologous to human TMC5 (transmembrane channel like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 18.1), large intestine adult (RPKM 16.3) and 7 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Tmc5 in Genome Data Viewer
Location:
7 F1- F2; 7 63.44 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (118196520..118274308)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (118597297..118675085)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane channel-like gene family 7 Neighboring gene RIKEN cDNA B230311B06 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:125849164-125849465 Neighboring gene glycerophosphodiester phosphodiesterase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4970 Neighboring gene centriolar coiled coil protein 110

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. Kurima K, et al. Genomics, 2003 Sep. PMID 12906855
  2. TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins. Keresztes G, et al. BMC Genomics, 2003 Jun 17. PMID 12812529, Free PMC Article
  3. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC118178

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mechanosensitive monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transmembrane channel-like protein 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105252.1 → NP_001098722.1  transmembrane channel-like protein 5 isoform a

    See identical proteins and their annotated locations for NP_001098722.1

    Status: VALIDATED

    Source sequence(s)
    AC124444, AK028404, AV371065, BY777312
    Consensus CDS
    CCDS52374.1
    UniProtKB/Swiss-Prot
    Q32NZ6, Q7TN61, Q80VR0, Q9D4F1
    Related
    ENSMUSP00000095694.5, ENSMUST00000098088.11
    Conserved Domains (1) summary
    pfam07810
    Location:686 → 791
    TMC; TMC domain

  2. NM_028930.3 → NP_083206.1  transmembrane channel-like protein 5 isoform b

    See identical proteins and their annotated locations for NP_083206.1

    Status: VALIDATED

    Source sequence(s)
    AC124444, AK016573, AK028404, AV371065, AY263159
    Consensus CDS
    CCDS21773.1
    UniProtKB/Swiss-Prot
    Q32NZ6
    Related
    ENSMUSP00000049784.8, ENSMUST00000057320.8
    Conserved Domains (1) summary
    pfam07810
    Location:481 → 576
    TMC; TMC domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    118196520..118274308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241924.3 → XP_011240226.1  transmembrane channel-like protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011240226.1

    UniProtKB/Swiss-Prot
    Q32NZ6, Q7TN61, Q80VR0, Q9D4F1
    Conserved Domains (1) summary
    pfam07810
    Location:686 → 791
    TMC; TMC domain

  2. XM_006508253.3 → XP_006508316.1  transmembrane channel-like protein 5 isoform X2

    Conserved Domains (1) summary
    pfam07810
    Location:679 → 784
    TMC; TMC domain

  3. XM_030243039.1 → XP_030098899.1  transmembrane channel-like protein 5 isoform X3

    Conserved Domains (1) summary
    pfam07810
    Location:365 → 470
    TMC; TMC domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q32NZ6.1 GenPept UniProtKB/Swiss-Prot:Q32NZ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous