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Tc2n tandem C2 domains, nuclear [ Mus musculus (house mouse) ]

Gene ID: 74413, updated on 5-Mar-2024

Summary

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Official Symbol
Tc2nprovided by MGI
Official Full Name
tandem C2 domains, nuclearprovided by MGI
Primary source
MGI:MGI:1921663
See related
Ensembl:ENSMUSG00000021187 AllianceGenome:MGI:1921663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tac2-N; Mtac2d1; 4933406D09Rik
Summary
Located in nucleus. Orthologous to human TC2N (tandem C2 domains, nuclear). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 2.4), testis adult (RPKM 0.5) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 E; 12 51.26 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (101611705..101685178, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (101645446..101718919, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene cation channel, sperm-associated, beta pseudogene Neighboring gene predicted gene, 22749 Neighboring gene STARR-seq mESC enhancer starr_33085 Neighboring gene cation channel sperm associated auxiliary subunit beta Neighboring gene STARR-seq mESC enhancer starr_33086 Neighboring gene predicted gene, 52022 Neighboring gene STARR-seq mESC enhancer starr_33088 Neighboring gene fibulin 5 Neighboring gene STARR-seq mESC enhancer starr_33091 Neighboring gene thyroid hormone receptor interactor 11 Neighboring gene predicted gene, 20036

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tac2-N, an atypical C-type tandem C2 protein localized in the nucleus. Fukuda M, et al. FEBS Lett, 2001 Aug 17. PMID 11526914
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tandem C2 domains nuclear protein
Names
membrane targeting (tandem) C2 domain containing 1
membrane targeting tandem C2 domain-containing protein 1
tandem C2 protein in nucleus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082976.2 → NP_001076445.1  tandem C2 domains nuclear protein

    See identical proteins and their annotated locations for NP_001076445.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC125355, AK016683, AK136558, EH095356
    Consensus CDS
    CCDS36524.1
    UniProtKB/Swiss-Prot
    Q3UW74, Q91XT6, Q9D4A0
    UniProtKB/TrEMBL
    E0CXQ6
    Related
    ENSMUSP00000125288.2, ENSMUST00000162735.8
    Conserved Domains (2) summary
    cd08684
    Location:239 → 341
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:352 → 486
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

  2. NM_028924.3 → NP_083200.1  tandem C2 domains nuclear protein

    See identical proteins and their annotated locations for NP_083200.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC125355, BC120793, BE624960, EH095356
    Consensus CDS
    CCDS36524.1
    UniProtKB/Swiss-Prot
    Q3UW74, Q91XT6, Q9D4A0
    UniProtKB/TrEMBL
    E0CXQ6
    Related
    ENSMUSP00000124287.2, ENSMUST00000160830.2
    Conserved Domains (2) summary
    cd08684
    Location:239 → 341
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:352 → 486
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    101611705..101685178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516303.4 → XP_006516366.1  tandem C2 domains nuclear protein isoform X1

    See identical proteins and their annotated locations for XP_006516366.1

    UniProtKB/Swiss-Prot
    Q3UW74, Q91XT6, Q9D4A0
    UniProtKB/TrEMBL
    E0CXQ6
    Conserved Domains (2) summary
    cd08684
    Location:239 → 341
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:352 → 486
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

  2. XM_011244191.3 → XP_011242493.1  tandem C2 domains nuclear protein isoform X1

    See identical proteins and their annotated locations for XP_011242493.1

    UniProtKB/Swiss-Prot
    Q3UW74, Q91XT6, Q9D4A0
    UniProtKB/TrEMBL
    E0CXQ6
    Conserved Domains (2) summary
    cd08684
    Location:239 → 341
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:352 → 486
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

  3. XM_017315217.3 → XP_017170706.1  tandem C2 domains nuclear protein isoform X1

    UniProtKB/Swiss-Prot
    Q3UW74, Q91XT6, Q9D4A0
    UniProtKB/TrEMBL
    E0CXQ6
    Conserved Domains (2) summary
    cd08684
    Location:239 → 341
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:352 → 486
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

  4. XM_006516301.5 → XP_006516364.1  tandem C2 domains nuclear protein isoform X1

    See identical proteins and their annotated locations for XP_006516364.1

    UniProtKB/Swiss-Prot
    Q3UW74, Q91XT6, Q9D4A0
    UniProtKB/TrEMBL
    E0CXQ6
    Conserved Domains (2) summary
    cd08684
    Location:239 → 341
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:352 → 486
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

  5. XM_011244192.2 → XP_011242494.1  tandem C2 domains nuclear protein isoform X1

    See identical proteins and their annotated locations for XP_011242494.1

    UniProtKB/Swiss-Prot
    Q3UW74, Q91XT6, Q9D4A0
    UniProtKB/TrEMBL
    E0CXQ6
    Conserved Domains (2) summary
    cd08684
    Location:239 → 341
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:352 → 486
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

  6. XM_006516306.2 → XP_006516369.1  tandem C2 domains nuclear protein isoform X3

    Conserved Domains (2) summary
    cd08684
    Location:57 → 159
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cl14603
    Location:170 → 304
    C2; C2 domain

  7. XM_006516305.3 → XP_006516368.1  tandem C2 domains nuclear protein isoform X2

    Conserved Domains (2) summary
    cd08684
    Location:109 → 211
    C2A_Tac2-N; C2 domain first repeat found in Tac2-N (Tandem C2 protein in Nucleus)
    cd08692
    Location:222 → 356
    C2B_Tac2-N; C2 domain second repeat found in Tac2-N (Tandem C2 protein in Nucleus)

RNA

  1. XR_001780495.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001286364.1: Suppressed sequence

    Description
    NM_001286364.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XT6.2 GenPept UniProtKB/Swiss-Prot:Q91XT6

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