U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gle1 GLE1 RNA export mediator [ Mus musculus (house mouse) ]

Gene ID: 74412, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gle1provided by MGI
Official Full Name
GLE1 RNA export mediatorprovided by MGI
Primary source
MGI:MGI:1921662
See related
Ensembl:ENSMUSG00000019715 AllianceGenome:MGI:1921662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gle1l; 4933405K21Rik
Summary
Predicted to enable several functions, including identical protein binding activity; inositol hexakisphosphate binding activity; and translation initiation factor binding activity. Predicted to be involved in mRNA export from nucleus; regulation of translational initiation; and regulation of translational termination. Predicted to act upstream of or within mRNA transport and protein transport. Predicted to be located in cytosol; microtubule organizing center; and nucleus. Predicted to be part of nuclear pore cytoplasmic filaments. Predicted to be active in cytoplasm. Is expressed in brain; cerebral cortex; and hippocampus. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 1. Orthologous to human GLE1 (GLE1 RNA export mediator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 15.0), CNS E18 (RPKM 14.4) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
2 B; 2 20.88 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29825421..29849444)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (29935409..29959432)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cerebral endothelial cell adhesion molecule Neighboring gene RIKEN cDNA 2600006K01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:29724576-29724685 Neighboring gene STARR-positive B cell enhancer ABC_E1583 Neighboring gene outer dense fiber of sperm tails 2 Neighboring gene STARR-positive B cell enhancer ABC_E4425 Neighboring gene STARR-seq mESC enhancer starr_04079 Neighboring gene STARR-seq mESC enhancer starr_04080 Neighboring gene spectrin alpha, non-erythrocytic 1 Neighboring gene microRNA 6997 Neighboring gene STARR-seq mESC enhancer starr_04082 Neighboring gene dynein 2 intermediate chain 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain. Valnegri P, et al. Nat Commun, 2017 Nov 2. PMID 29097665, Free PMC Article
  2. Peering through the pore: nuclear pore complex structure, assembly, and function. Suntharalingam M, et al. Dev Cell, 2003 Jun. PMID 12791264
  3. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables inositol hexakisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore NAS
Non-traceable Author Statement
more info
 PubMed 
part_of nuclear pore cytoplasmic filaments IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
mRNA export factor GLE1
Names
GLE1-like protein
nucleoporin GLE1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028923.3 → NP_083199.1  mRNA export factor GLE1

    See identical proteins and their annotated locations for NP_083199.1

    Status: VALIDATED

    Source sequence(s)
    AK145748, AL928926, BY673167
    Consensus CDS
    CCDS15862.1
    UniProtKB/Swiss-Prot
    A3KGV8, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q8R322, Q9D4A6
    Related
    ENSMUSP00000019859.9, ENSMUST00000019859.9
    Conserved Domains (2) summary
    pfam07817
    Location:410 → 648
    GLE1; GLE1-like protein
    cl23765
    Location:169 → 288
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    29825421..29849444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162642.1 → XP_036018535.1  mRNA export factor GLE1 isoform X1

    Conserved Domains (1) summary
    pfam07817
    Location:92 → 327
    GLE1; GLE1-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R322.2 GenPept UniProtKB/Swiss-Prot:Q8R322

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous