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Ttll11 tubulin tyrosine ligase-like family, member 11 [ Mus musculus (house mouse) ]

Gene ID: 74410, updated on 30-Apr-2024

Summary

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Official Symbol
Ttll11provided by MGI
Official Full Name
tubulin tyrosine ligase-like family, member 11provided by MGI
Primary source
MGI:MGI:1921660
See related
Ensembl:ENSMUSG00000026885 AllianceGenome:MGI:1921660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D2Ertd624e; 4932702F08Rik; 4933424A20Rik
Summary
Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Acts upstream of or within microtubule severing and protein polyglutamylation. Located in ciliary basal body. Is expressed in retina. Orthologous to human TTLL11 (tubulin tyrosine ligase like 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 19.6), cortex adult (RPKM 7.2) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 B; 2 23.9 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (35641250..35870250, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (35751240..35979820, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:35359725-35359878 Neighboring gene STARR-seq mESC enhancer starr_04284 Neighboring gene predicted gene, 35260 Neighboring gene predicted gene, 35202 Neighboring gene STARR-seq mESC enhancer starr_04285 Neighboring gene predicted gene 13446 Neighboring gene STARR-seq mESC enhancer starr_04286 Neighboring gene disabled 2 interacting protein Neighboring gene STARR-seq mESC enhancer starr_04289 Neighboring gene STARR-seq mESC enhancer starr_04292 Neighboring gene RIKEN cDNA 9030204H09 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:35686851-35687121 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:35696893-35697094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:35697143-35697252 Neighboring gene predicted gene 10829 Neighboring gene predicted gene, 35396 Neighboring gene STARR-positive B cell enhancer ABC_E10098 Neighboring gene STARR-seq mESC enhancer starr_04294 Neighboring gene STARR-seq mESC enhancer starr_04295 Neighboring gene STARR-positive B cell enhancer mm9_chr2:35904821-35905122 Neighboring gene predicted gene, 39798 Neighboring gene NADH:ubiquinone oxidoreductase subunit A8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TTLL1 and TTLL4 polyglutamylases are required for the neurodegenerative phenotypes in pcd mice. Wu HY, et al. PLoS Genet, 2022 Apr. PMID 35404950, Free PMC Article
  2. Tubulin polyglutamylation stimulates spastin-mediated microtubule severing. Lacroix B, et al. J Cell Biol, 2010 Jun 14. PMID 20530212, Free PMC Article
  3. A targeted multienzyme mechanism for selective microtubule polyglutamylation. van Dijk J, et al. Mol Cell, 2007 May 11. PMID 17499049
  4. Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Ye B, et al. Nat Commun, 2018 Mar 28. PMID 29593216, Free PMC Article
  5. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin-glutamic acid ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule severing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within microtubule severing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyglutamylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein polyglutamylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tubulin polyglutamylase TTLL11
Names
polyglutamylase
tubulin--tyrosine ligase-like protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029774.3 → NP_084050.1  tubulin polyglutamylase TTLL11

    See identical proteins and their annotated locations for NP_084050.1

    Status: VALIDATED

    Source sequence(s)
    AL732413, AL773525, AL845477
    Consensus CDS
    CCDS50579.1
    UniProtKB/Swiss-Prot
    A4Q9F4, Q1LZJ9, Q9D4E7
    Related
    ENSMUSP00000028248.5, ENSMUST00000028248.11
    Conserved Domains (1) summary
    cl17255
    Location:178 → 445
    ATP-grasp_4; ATP-grasp domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    35641250..35870250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162641.1 → XP_036018534.1  tubulin polyglutamylase TTLL11 isoform X1

    Related
    ENSMUSP00000108600.3, ENSMUST00000112976.9
    Conserved Domains (1) summary
    cl17255
    Location:178 → 445
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028921.2: Suppressed sequence

    Description
    NM_028921.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4Q9F4.1 GenPept UniProtKB/Swiss-Prot:A4Q9F4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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