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Zfp819 zinc finger protein 819 [ Mus musculus (house mouse) ]

Gene ID: 74400, updated on 21-Apr-2024

Summary

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Official Symbol
Zfp819provided by MGI
Official Full Name
zinc finger protein 819provided by MGI
Primary source
MGI:MGI:1921650
See related
Ensembl:ENSMUSG00000055102 AllianceGenome:MGI:1921650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930427I11Rik; 4933405K07Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription, DNA-templated and positive regulation of apoptotic process. Located in nucleus. Is expressed in brain; early conceptus; eye; and inner ear. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 2.3) and CNS E11.5 (RPKM 0.1) See more
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Genomic context

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Location:
7 B3; 7 28.25 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43256559..43267703)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43607135..43618279)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 658 Neighboring gene STARR-positive B cell enhancer ABC_E9290 Neighboring gene zinc finger protein 719 Neighboring gene STARR-seq mESC enhancer starr_18778 Neighboring gene STARR-seq mESC enhancer starr_18779 Neighboring gene CEA cell adhesion molecule 18 Neighboring gene sialic acid binding Ig-like lectin E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819. Fernandes LP, et al. Sci Adv, 2022 Oct 28. PMID 36306355, Free PMC Article
  2. Identification and characterization of reproductive KRAB-ZF genes in mice. Jin S, et al. Gene, 2015 Jul 1. PMID 25827285
  3. Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells. Tan X, et al. Stem Cell Res, 2013 Nov. PMID 23954693
  4. Generation and characterization of yeast two-hybrid cDNA libraries derived from two distinct mouse pluripotent cell types. Zheng Y, et al. Mol Biotechnol, 2013 Jun. PMID 22674187, Free PMC Article
  5. Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing. Sah RK, et al. PLoS One, 2019. PMID 31291246, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819.
    Title: A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819.
  2. Results show that Zfp819 is expressed exclusively in spermatogenic cells. Its overexpression suppressed cell proliferation and induced apoptosis.
    Title: Identification and characterization of reproductive KRAB-ZF genes in mice.
  3. Zfp819 is a novel pluripotency-related factor and unveiled its function in genomic integrity maintenance mechanisms of mouse embryonic stem cells.
    Title: Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 819

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355131.1 → NP_001342060.1  zinc finger protein 819 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154108
    Consensus CDS
    CCDS90218.1
    UniProtKB/TrEMBL
    E9Q5X9
    Related
    ENSMUSP00000113867.2, ENSMUST00000120935.2
    Conserved Domains (3) summary
    COG5048
    Location:217 → 455
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:366 → 386
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:463 → 487
    zf-H2C2_2; Zinc-finger double domain

  2. NM_028913.3 → NP_083189.2  zinc finger protein 819 isoform 1

    See identical proteins and their annotated locations for NP_083189.2

    Status: VALIDATED

    Source sequence(s)
    AC154108, AK016669
    Consensus CDS
    CCDS21176.1
    UniProtKB/TrEMBL
    Q80V81
    Related
    ENSMUSP00000032661.7, ENSMUST00000032661.14
    Conserved Domains (4) summary
    smart00349
    Location:27 → 81
    KRAB; krueppel associated box
    COG5048
    Location:293 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:539 → 563
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43256559..43267703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312353.2 → XP_017167842.1  zinc finger protein 819 isoform X1

    UniProtKB/TrEMBL
    Q80V81
    Conserved Domains (4) summary
    smart00349
    Location:27 → 81
    KRAB; krueppel associated box
    COG5048
    Location:293 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:442 → 462
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:539 → 563
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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