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Ap5m1 adaptor-related protein complex 5, mu 1 subunit [ Mus musculus (house mouse) ]

Gene ID: 74385, updated on 5-Mar-2024

Summary

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Official Symbol
Ap5m1provided by MGI
Official Full Name
adaptor-related protein complex 5, mu 1 subunitprovided by MGI
Primary source
MGI:MGI:1921635
See related
Ensembl:ENSMUSG00000036291 AllianceGenome:MGI:1921635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mu5; Mudeng; 4932432K03Rik
Summary
Predicted to be involved in endosomal transport. Predicted to act upstream of or within protein transport. Predicted to be located in membrane. Predicted to be part of AP-type membrane coat adaptor complex. Predicted to be active in cytosol; late endosome; and lysosome. Orthologous to human AP5M1 (adaptor related protein complex 5 subunit mu 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 4.2), limb E14.5 (RPKM 4.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C1; 14 25.36 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (49303869..49331681)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (49066408..49094114)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36024 Neighboring gene STARR-seq mESC enhancer starr_36624 Neighboring gene predicted gene, 23470 Neighboring gene exocyst complex component 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:49686153-49686414 Neighboring gene ribosomal protein L19, pseudogene 3 Neighboring gene VISTA enhancer mm1570 Neighboring gene STARR-seq mESC enhancer starr_36626 Neighboring gene STARR-seq mESC enhancer starr_36627 Neighboring gene N(alpha)-acetyltransferase 30, NatC catalytic subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel protein, MUDENG, induces cell death in cytotoxic T cells. Lee MR, et al. Biochem Biophys Res Commun, 2008 Jun 6. PMID 18395520
  2. The fifth adaptor protein complex. Hirst J, et al. PLoS Biol, 2011 Oct. PMID 22022230, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-5 adaptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of AP-type membrane coat adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-type membrane coat adaptor complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
AP-5 complex subunit mu-1
Names
MHD domain-containing death-inducing protein
MU-2/AP1M2 domain containing, death-inducing
adapter-related protein complex 5 mu subunit
adapter-related protein complex 5 subunit mu-1
adaptor-related protein complex 5 subunit mu-1
mu-2-related death-inducing protein
muD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360070.1 → NP_001346999.1  AP-5 complex subunit mu-1

    Status: VALIDATED

    Source sequence(s)
    AK016540, AK030928, CT025618
    Consensus CDS
    CCDS26995.1
    UniProtKB/Swiss-Prot
    Q3TDF2, Q3TPT5, Q8BII2, Q8BJ31, Q8BJ58, Q8BJ63, Q8BY11, Q8R5B1
    UniProtKB/TrEMBL
    A0A0R4J0K9
    Conserved Domains (1) summary
    cd09256
    Location:196 → 482
    AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

  2. NM_144535.5 → NP_653118.3  AP-5 complex subunit mu-1

    See identical proteins and their annotated locations for NP_653118.3

    Status: VALIDATED

    Source sequence(s)
    AK016540, AK030928, AK051372, AK164148
    Consensus CDS
    CCDS26995.1
    UniProtKB/Swiss-Prot
    Q3TDF2, Q3TPT5, Q8BII2, Q8BJ31, Q8BJ58, Q8BJ63, Q8BY11, Q8R5B1
    UniProtKB/TrEMBL
    A0A0R4J0K9
    Related
    ENSMUSP00000046536.5, ENSMUST00000037473.6
    Conserved Domains (1) summary
    cd09256
    Location:196 → 482
    AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    49303869..49331681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245212.4 → XP_011243514.1  AP-5 complex subunit mu-1 isoform X1

    See identical proteins and their annotated locations for XP_011243514.1

    UniProtKB/Swiss-Prot
    Q3TDF2, Q3TPT5, Q8BII2, Q8BJ31, Q8BJ58, Q8BJ63, Q8BY11, Q8R5B1
    UniProtKB/TrEMBL
    A0A0R4J0K9
    Conserved Domains (1) summary
    cd09256
    Location:196 → 482
    AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

  2. XM_006519623.5 → XP_006519686.1  AP-5 complex subunit mu-1 isoform X1

    See identical proteins and their annotated locations for XP_006519686.1

    UniProtKB/Swiss-Prot
    Q3TDF2, Q3TPT5, Q8BII2, Q8BJ31, Q8BJ58, Q8BJ63, Q8BY11, Q8R5B1
    UniProtKB/TrEMBL
    A0A0R4J0K9
    Conserved Domains (1) summary
    cd09256
    Location:196 → 482
    AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

  3. XM_006519626.5 → XP_006519689.1  AP-5 complex subunit mu-1 isoform X3

    Conserved Domains (1) summary
    cd09256
    Location:1 → 263
    AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

  4. XM_036158881.1 → XP_036014774.1  AP-5 complex subunit mu-1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TDF2, Q3TPT5, Q8BII2, Q8BJ31, Q8BJ58, Q8BJ63, Q8BY11, Q8R5B1
    Conserved Domains (1) summary
    cd09256
    Location:196 → 406
    AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

  5. XM_006519624.5 → XP_006519687.1  AP-5 complex subunit mu-1 isoform X2

    UniProtKB/Swiss-Prot
    Q3TDF2, Q3TPT5, Q8BII2, Q8BJ31, Q8BJ58, Q8BJ63, Q8BY11, Q8R5B1
    Conserved Domains (1) summary
    cd09256
    Location:196 → 406
    AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

  6. XM_036158882.1 → XP_036014775.1  AP-5 complex subunit mu-1 isoform X3

    Conserved Domains (1) summary
    cd09256
    Location:1 → 263
    AP_MuD_MHD; Mu-homology domain (MHD) of a adaptor protein (AP) encoded by mu-2 related death-inducing gene, MuD (also known as MUDENG)

RNA

  1. XR_003950905.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJ63.2 GenPept UniProtKB/Swiss-Prot:Q8BJ63

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