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Hsf2bp heat shock transcription factor 2 binding protein [ Mus musculus (house mouse) ]

Gene ID: 74377, updated on 21-Apr-2024

Summary

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Official Symbol
Hsf2bpprovided by MGI
Official Full Name
heat shock transcription factor 2 binding proteinprovided by MGI
Primary source
MGI:MGI:1921627
See related
Ensembl:ENSMUSG00000002076 AllianceGenome:MGI:1921627
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Meilb2; 4932437G14Rik
Summary
Involved in meiosis I and spermatogenesis. Located in chromosome. Is expressed in several structures, including genitourinary system; nervous system; sensory organ; surface ectoderm; and thymus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 19. Orthologous to human HSF2BP (heat shock transcription factor 2 binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 5.3), kidney adult (RPKM 0.7) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 17.25 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (32163743..32253869, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31944769..32034895, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310015A16 gene Neighboring gene predicted gene, 30571 Neighboring gene STARR-seq mESC enhancer starr_42364 Neighboring gene ribosomal RNA processing 1B Neighboring gene STARR-seq mESC enhancer starr_42366 Neighboring gene STARR-positive B cell enhancer ABC_E4204 Neighboring gene pyridoxal (pyridoxine, vitamin B6) kinase, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. HSF2BP protects against acute liver injury by regulating HSF2/HSP70/MAPK signaling in mice. Bi J, et al. Cell Death Dis, 2022 Sep 27. PMID 36167792, Free PMC Article
  2. HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair. Sato K, et al. Nucleic Acids Res, 2020 Mar 18. PMID 31960047, Free PMC Article
  3. HSF2BP represses BNC1 transcriptional activity by sequestering BNC1 to the cytoplasm. Wu Y, et al. FEBS Lett, 2013 Jul 11. PMID 23707421
  4. MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis. Shang Y, et al. Nucleic Acids Res, 2020 Jul 9. PMID 32463460, Free PMC Article
  5. Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic Recombination. Takemoto K, et al. Cell Rep, 2020 May 26. PMID 32460033

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HSF2BP protects against acute liver injury by regulating HSF2/HSP70/MAPK signaling in mice.
    Title: HSF2BP protects against acute liver injury by regulating HSF2/HSP70/MAPK signaling in mice.
  2. A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.
    Title: A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1.
  3. BRCA2 binds to the C-terminus of MEILB2, resulting in the formation of the BRCA2-MEILB2-BRME1 ternary complex.
    Title: The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.
  4. HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
    Title: HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
  5. Naturally occurring elevated production of HSF2BP in tumors may be a source of cancer-promoting genomic instability and also a targetable vulnerability.
    Title: HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair.
  6. HSF2BP may play a pivotal role in regulating BNC1 transcriptional activity and subcellular localization during spermatogenesis.
    Title: HSF2BP represses BNC1 transcriptional activity by sequestering BNC1 to the cytoplasm.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair involved in meiotic recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in female meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male meiosis I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermatogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
heat shock factor 2-binding protein
Names
meiotic localizer of BRCA2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028902.1 → NP_083178.1  heat shock factor 2-binding protein

    See identical proteins and their annotated locations for NP_083178.1

    Status: VALIDATED

    Source sequence(s)
    AK016553, DV650538
    Consensus CDS
    CCDS50056.1
    UniProtKB/Swiss-Prot
    Q9D4G2
    UniProtKB/TrEMBL
    A0A3T0ZJB3
    Related
    ENSMUSP00000002145.6, ENSMUST00000002145.12
    Conserved Domains (1) summary
    TIGR03319
    Location:12 → 122
    RNase_Y; ribonuclease Y

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    32163743..32253869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525035.4 → XP_006525098.1  heat shock factor 2-binding protein isoform X1

    Conserved Domains (1) summary
    PRK12704
    Location:2 → 105
    PRK12704; phosphodiesterase; Provisional

  2. XM_030250120.1 → XP_030105980.1  heat shock factor 2-binding protein isoform X2

    UniProtKB/TrEMBL
    F6UJ67
    Related
    ENSMUSP00000115909.3, ENSMUST00000133308.3
    Conserved Domains (1) summary
    TIGR02169
    Location:12 → 123
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D4G2.1 GenPept UniProtKB/Swiss-Prot:Q9D4G2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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