U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mei1 meiotic double-stranded break formation protein 1 [ Mus musculus (house mouse) ]

Gene ID: 74369, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Mei1provided by MGI
Official Full Name
meiotic double-stranded break formation protein 1provided by MGI
Primary source
MGI:MGI:3028590
See related
Ensembl:ENSMUSG00000068117 AllianceGenome:MGI:3028590
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mei1; 4932408F18Rik
Summary
Acts upstream of or within gamete generation; meiotic spindle organization; and meiotic telomere clustering. Is expressed in brain; ovary; and testis. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to human MEI1 (meiotic double-stranded break formation protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 3.0), cortex adult (RPKM 1.4) and 2 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
15 E1; 15 38.41 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81954275..82011018)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82070074..82126817)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7400 Neighboring gene RIKEN cDNA 4930407I10 gene Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) Neighboring gene STARR-seq mESC enhancer starr_39280 Neighboring gene STARR-seq mESC enhancer starr_39281 Neighboring gene STARR-positive B cell enhancer ABC_E8600 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:81965919-81966120 Neighboring gene coiled-coil domain containing 134 Neighboring gene STARR-seq mESC enhancer starr_39283 Neighboring gene sterol regulatory element binding factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E5500 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:81996613-81996854 Neighboring gene STARR-seq mESC enhancer starr_39286 Neighboring gene microRNA 33

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A dominant, recombination-defective allele of Dmc1 causing male-specific sterility. Bannister LA, et al. PLoS Biol, 2007 May. PMID 17425408, Free PMC Article
  2. Causative Mutations and Mechanism of Androgenetic Hydatidiform Moles. Nguyen NMP, et al. Am J Hum Genet, 2018 Nov 1. PMID 30388401, Free PMC Article
  3. Mei1 is epistatic to Dmc1 during mouse meiosis. Reinholdt LG, et al. Chromosoma, 2005 Jul. PMID 15928951
  4. The mouse meiotic mutation mei1 disrupts chromosome synapsis with sexually dimorphic consequences for meiotic progression. Libby BJ, et al. Dev Biol, 2002 Feb 15. PMID 11820814
  5. Homologous pairing preceding SPO11-mediated double-strand breaks in mice. Boateng KA, et al. Dev Cell, 2013 Jan 28. PMID 23318132, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mei1 is required for vertebrate meiosis.
    Title: Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice.
  2. Mei1 can be positioned upstream of Dmc1 in the genetic pathway that operates during mammalian meiosis.
    Title: Mei1 is epistatic to Dmc1 during mouse meiosis.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (other) (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within gamete generation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leptotene IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within male meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiosis I IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic telomere clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within oogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within polar body extrusion after meiotic divisions IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
meiosis inhibitor protein 1
Names
meiosis defective protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310435.1 → NP_001297364.1  meiosis inhibitor protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001297364.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC102176, AK016514
    Consensus CDS
    CCDS79396.1
    UniProtKB/Swiss-Prot
    Q9D4I2
    Related
    ENSMUSP00000139689.2, ENSMUST00000188048.7

  2. NM_028897.3 → NP_083173.2  meiosis inhibitor protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102176, AK016514, BY641487
    Consensus CDS
    CCDS88810.1
    UniProtKB/Swiss-Prot
    B2RQ44, F8WHB9, Q9D4I2
    UniProtKB/TrEMBL
    A0A2R8VHD2
    Related
    ENSMUSP00000086582.6, ENSMUST00000089178.11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    81954275..82011018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521494.4 → XP_006521557.1  meiosis inhibitor protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A2R8VHD2

  2. XM_006521495.4 → XP_006521558.1  meiosis inhibitor protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A2R8VHD2

  3. XM_017316770.2 → XP_017172259.1  meiosis inhibitor protein 1 isoform X4

  4. XM_006521496.5 → XP_006521559.1  meiosis inhibitor protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006521559.1

    UniProtKB/TrEMBL
    A0A2R8VHD2

  5. XM_030248803.2 → XP_030104663.1  meiosis inhibitor protein 1 isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D4I2.4 GenPept UniProtKB/Swiss-Prot:Q9D4I2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous