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Ddx23 DEAD box helicase 23 [ Mus musculus (house mouse) ]

Gene ID: 74351, updated on 5-Mar-2024

Summary

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Official Symbol
Ddx23provided by MGI
Official Full Name
DEAD box helicase 23provided by MGI
Primary source
MGI:MGI:1921601
See related
Ensembl:ENSMUSG00000003360 AllianceGenome:MGI:1921601
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3110082M05Rik; 4921506D17Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in R-loop disassembly and mRNA splicing, via spliceosome. Predicted to be located in chromatin; nucleolus; and nucleoplasm. Predicted to be part of U4/U6 x U5 tri-snRNP complex; U5 snRNP; and catalytic step 2 spliceosome. Orthologous to human DDX23 (DEAD-box helicase 23). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 28.2), thymus adult (RPKM 18.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ddx23 in Genome Data Viewer
Location:
15 F1; 15 54.65 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98543012..98560808, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98645379..98662928, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene sperm microtubule inner protein 11 Neighboring gene adenylate cyclase 6 Neighboring gene STARR-seq mESC enhancer starr_39665 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98440580-98440763 Neighboring gene STARR-positive B cell enhancer ABC_E9921 Neighboring gene STARR-seq mESC enhancer starr_39668 Neighboring gene calcium channel, voltage-dependent, beta 3 subunit Neighboring gene STARR-positive B cell enhancer ABC_E8612 Neighboring gene STARR-positive B cell enhancer ABC_E9922 Neighboring gene Rho family GTPase 1 Neighboring gene predicted gene, 34152

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article
  2. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in R-loop processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
  
part_of U5 snRNP ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX23
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
NP_001074450.1
XP_006521556.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080981.1 → NP_001074450.1  probable ATP-dependent RNA helicase DDX23

    See identical proteins and their annotated locations for NP_001074450.1

    Status: PROVISIONAL

    Source sequence(s)
    AC156543
    Consensus CDS
    CCDS37193.1
    UniProtKB/TrEMBL
    D3Z0M9
    Related
    ENSMUSP00000003450.9, ENSMUST00000003450.15
    Conserved Domains (4) summary
    TIGR01622
    Location:79 → 207
    SF-CC1; splicing factor, CC1-like family
    cd18787
    Location:638 → 767
    SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
    cd17945
    Location:401 → 627
    DEADc_DDX23; DEAD-box helicase domain of DEAD box protein 23
    pfam17380
    Location:163 → 350
    DUF5401; Family of unknown function (DUF5401)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98543012..98560808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521493.5 → XP_006521556.1  probable ATP-dependent RNA helicase DDX23 isoform X1

    See identical proteins and their annotated locations for XP_006521556.1

    UniProtKB/TrEMBL
    D3Z0M9
    Conserved Domains (4) summary
    TIGR01622
    Location:79 → 207
    SF-CC1; splicing factor, CC1-like family
    cd18787
    Location:638 → 767
    SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases
    cd17945
    Location:401 → 627
    DEADc_DDX23; DEAD-box helicase domain of DEAD box protein 23
    pfam17380
    Location:163 → 350
    DUF5401; Family of unknown function (DUF5401)
Nucleotide Protein Strain
Heading Accession and Version

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