U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Crtc2 CREB regulated transcription coactivator 2 [ Mus musculus (house mouse) ]

Gene ID: 74343, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Crtc2provided by MGI
Official Full Name
CREB regulated transcription coactivator 2provided by MGI
Primary source
MGI:MGI:1921593
See related
Ensembl:ENSMUSG00000027936 AllianceGenome:MGI:1921593
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Torc2; 4632407F12Rik
Summary
Predicted to enable cAMP response element binding protein binding activity and chromatin binding activity. Involved in gluconeogenesis; glucose homeostasis; and positive regulation of CREB transcription factor activity. Acts upstream of or within histone H3-K9 acetylation; positive regulation of transcription by RNA polymerase II; and toxin transport. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; ear; integumental system; limb; and nervous system. Orthologous to human CRTC2 (CREB regulated transcription coactivator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 33.2), thymus adult (RPKM 31.7) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3 F1; 3 39.21 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90161475..90171432)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90253858..90264125)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 3-like 4 Neighboring gene jumping translocation breakpoint Neighboring gene STARR-positive B cell enhancer ABC_E1265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90052523-90052632 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90057967-90058076 Neighboring gene solute carrier family 39 (zinc transporter), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E4558 Neighboring gene DENN domain containing 4B Neighboring gene microRNA 7012 Neighboring gene STARR-positive B cell enhancer ABC_E28 Neighboring gene GATA zinc finger domain containing 2B Neighboring gene STARR-seq mESC enhancer starr_08281

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Osteocytes autophagy mediated by mTORC2 activation controls osteoblasts differentiation and osteoclasts activities under mechanical loading. Gao L, et al. Arch Biochem Biophys, 2023 Jul 1. PMID 37164247
  2. A novel role of CRTC2 in promoting nonalcoholic fatty liver disease. Han HS, et al. Mol Metab, 2022 Jan. PMID 34838715, Free PMC Article
  3. CREB Coactivator CRTC2 Plays a Crucial Role in Endothelial Function. Kanki H, et al. J Neurosci, 2020 Dec 2. PMID 33127851, Free PMC Article
  4. CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers. Van de Velde S, et al. Mol Cell Biol, 2019 Sep 1. PMID 31182641, Free PMC Article
  5. A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP-2. Li Y, et al. Hepatology, 2017 Aug. PMID 28395113, Free PMC Article

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRTC2 activates the epithelial-mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway.
    Title: CRTC2 activates the epithelial-mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway.
  2. Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress.
    Title: Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress.
  3. Osteocytes autophagy mediated by mTORC2 activation controls osteoblasts differentiation and osteoclasts activities under mechanical loading.
    Title: Osteocytes autophagy mediated by mTORC2 activation controls osteoblasts differentiation and osteoclasts activities under mechanical loading.
  4. cAMP-Induced Nuclear Condensation of CRTC2 Promotes Transcription Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease.
    Title: cAMP-Induced Nuclear Condensation of CRTC2 Promotes Transcription Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease.
  5. Endoplasmic reticulum stress downregulates PGC-1alpha in skeletal muscle through ATF4 and an mTOR-mediated reduction of CRTC2.
    Title: Endoplasmic reticulum stress downregulates PGC-1α in skeletal muscle through ATF4 and an mTOR-mediated reduction of CRTC2.
  6. IL-1beta-activated mTORC2 promotes accumulation of IFN-gamma(+) gammadelta T cells by upregulating CXCR3 to restrict hepatic fibrosis.
    Title: IL-1β-activated mTORC2 promotes accumulation of IFN-γ(+) γδ T cells by upregulating CXCR3 to restrict hepatic fibrosis.
  7. A novel role of CRTC2 in promoting nonalcoholic fatty liver disease.
    Title: A novel role of CRTC2 in promoting nonalcoholic fatty liver disease.
  8. Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice.
    Title: Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice.
  9. A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex.
    Title: A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex.
  10. Sam68 promotes hepatic gluconeogenesis via CRTC2.
    Title: Sam68 promotes hepatic gluconeogenesis via CRTC2.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP response element binding protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in gluconeogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of CREB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of CREB transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein homotetramerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
CREB-regulated transcription coactivator 2
Names
TORC-2
transducer of CREB protein 2
transducer of regulated cAMP response element-binding protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357152.2 → NP_001344081.1  CREB-regulated transcription coactivator 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119825
    UniProtKB/TrEMBL
    Q3TDX5, Q8R1U3
    Related
    ENSMUST00000136970.8
    Conserved Domains (2) summary
    pfam12885
    Location:1 → 138
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:435 → 512
    TORC_C; Transducer of regulated CREB activity, C terminus

  2. NM_028881.4 → NP_083157.1  CREB-regulated transcription coactivator 2 isoform 1

    See identical proteins and their annotated locations for NP_083157.1

    Status: VALIDATED

    Source sequence(s)
    AC119825
    Consensus CDS
    CCDS38501.1
    UniProtKB/Swiss-Prot
    Q3TA52, Q3U182, Q8BH09
    Related
    ENSMUSP00000029545.9, ENSMUST00000029545.15
    Conserved Domains (3) summary
    pfam12884
    Location:18 → 72
    TORC_N; Transducer of regulated CREB activity, N terminus
    pfam12885
    Location:168 → 317
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:614 → 691
    TORC_C; Transducer of regulated CREB activity, C terminus

RNA

  1. NR_151631.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC119825

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    90161475..90171432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502153.1 → XP_006502216.1  CREB-regulated transcription coactivator 2 isoform X2

    Conserved Domains (3) summary
    pfam12884
    Location:18 → 72
    TORC_N; Transducer of regulated CREB activity, N-terminus
    pfam12885
    Location:168 → 317
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:526 → 603
    TORC_C; Transducer of regulated CREB activity, C-terminus

  2. XM_006502152.1 → XP_006502215.1  CREB-regulated transcription coactivator 2 isoform X1

    Conserved Domains (3) summary
    pfam12884
    Location:18 → 72
    TORC_N; Transducer of regulated CREB activity, N-terminus
    pfam12885
    Location:145 → 294
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:591 → 668
    TORC_C; Transducer of regulated CREB activity, C-terminus

RNA

  1. XR_001783761.1 RNA Sequence

  2. XR_375593.1 RNA Sequence

    Related
    ENSMUST00000184882.2

  3. XR_004941409.1 RNA Sequence

  4. XR_001783762.1 RNA Sequence

    Related
    ENSMUST00000130002.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U182.2 GenPept UniProtKB/Swiss-Prot:Q3U182

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous