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Palm3 paralemmin 3 [ Mus musculus (house mouse) ]

Gene ID: 74337, updated on 5-Mar-2024

Summary

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Official Symbol
Palm3provided by MGI
Official Full Name
paralemmin 3provided by MGI
Primary source
MGI:MGI:1921587
See related
Ensembl:ENSMUSG00000047986 AllianceGenome:MGI:1921587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4432412L15Rik
Summary
Predicted to enable ATP binding activity. Predicted to be involved in Toll signaling pathway; negative regulation of cytokine-mediated signaling pathway; and response to lipopolysaccharide. Predicted to be located in cytoplasm and plasma membrane. Is expressed in gut; nervous system; and urinary system. Orthologous to human PALM3 (paralemmin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 12.0), thymus adult (RPKM 3.0) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 C2; 8 40.25 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84747787..84757300)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84021157..84030671)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene microRNA 8111 Neighboring gene microRNA 1199 Neighboring gene MISP family member 3 Neighboring gene predicted gene, 53445 Neighboring gene interleukin 27 receptor, alpha Neighboring gene relaxin 3 Neighboring gene STARR-seq mESC enhancer starr_22106 Neighboring gene predicted gene 10643 Neighboring gene regulatory factor X, 1 (influences HLA class II expression)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Silencing of Paralemmin-3 Protects Mice from lipopolysaccharide-induced acute lung injury. Li S, et al. Peptides, 2016 Feb. PMID 26772416
  2. The paralemmin protein family: identification of paralemmin-2, an isoform differentially spliced to AKAP2/AKAP-KL, and of palmdelphin, a more distant cytosolic relative. Hu B, et al. Biochem Biophys Res Commun, 2001 Aug 3. PMID 11478809
  3. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PALM3 contributes to the development of acute lung injury in mice challenged with lipopolysaccharide.
    Title: Silencing of Paralemmin-3 Protects Mice from lipopolysaccharide-induced acute lung injury.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Toll signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Toll signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
paralemmin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028877.2 → NP_083153.1  paralemmin-3

    See identical proteins and their annotated locations for NP_083153.1

    Status: VALIDATED

    Source sequence(s)
    AC156028
    Consensus CDS
    CCDS40405.1
    UniProtKB/Swiss-Prot
    A2TJV2, Q9CRS0
    Related
    ENSMUSP00000051396.7, ENSMUST00000055077.7
    Conserved Domains (2) summary
    PRK03427
    Location:574 → 720
    PRK03427; cell division protein ZipA; Provisional
    TIGR00927
    Location:378 → 646
    2A1904; K+-dependent Na+/Ca+ exchanger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    84747787..84757300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312990.3 → XP_017168479.1  paralemmin-3 isoform X2

    Conserved Domains (1) summary
    PHA03324
    Location:20 → 87
    PHA03324; nuclear egress membrane protein UL34; Provisional

  2. XM_030243816.2 → XP_030099676.1  paralemmin-3 isoform X1

    Conserved Domains (1) summary
    TIGR00927
    Location:257 → 516
    2A1904; K+-dependent Na+/Ca+ exchanger
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2TJV2.1 GenPept UniProtKB/Swiss-Prot:A2TJV2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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