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Xrcc3 X-ray repair complementing defective repair in Chinese hamster cells 3 [ Mus musculus (house mouse) ]

Gene ID: 74335, updated on 5-Mar-2024

Summary

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Official Symbol
Xrcc3provided by MGI
Official Full Name
X-ray repair complementing defective repair in Chinese hamster cells 3provided by MGI
Primary source
MGI:MGI:1921585
See related
Ensembl:ENSMUSG00000021287 AllianceGenome:MGI:1921585
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. Allelic variants in the human gene are associated with susceptibility to breast cancer and cutaneous malignant melanoma. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in ovary adult (RPKM 17.4), colon adult (RPKM 14.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Xrcc3 in Genome Data Viewer
Location:
12 F1; 12 61.14 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111769626..111780326, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111803192..111813893, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36635 Neighboring gene BCL2-associated athanogene 5 Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene STARR-seq mESC enhancer starr_33333 Neighboring gene STARR-positive B cell enhancer ABC_E7188 Neighboring gene kinesin light chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E209 Neighboring gene zinc finger, FYVE domain containing 21 Neighboring gene protein phosphatase 1, regulatory subunit 13B Neighboring gene predicted gene, 53769

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A naturally occurring mutation in an ATP-binding domain of the recombination repair gene XRCC3 ablates its function without causing cancer susceptibility. Rafii S, et al. Hum Mol Genet, 2003 Apr 15. PMID 12668615
  2. Role of RAD51C and XRCC3 in genetic recombination and DNA repair. Liu Y, et al. J Biol Chem, 2007 Jan 19. PMID 17114795
  3. XRCC3 loss leads to midgestational embryonic lethality in mice. Prakash R, et al. DNA Repair (Amst), 2021 Dec. PMID 34601382, Free PMC Article
  4. siRNA screening identifies differences in the Fanconi anemia pathway in BALB/c-Trp53+/- with susceptibility versus C57BL/6-Trp53+/- mice with resistance to mammary tumors. Böhringer M, et al. Oncogene, 2013 Nov 28. PMID 23435420, Free PMC Article
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 4432412E01Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to crossover junction DNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to four-way junction DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to four-way junction DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via synthesis-dependent strand annealing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of centrosome duplication ISO
Inferred from Sequence Orthology
more info
  
involved_in resolution of mitotic recombination intermediates IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in resolution of mitotic recombination intermediates ISO
Inferred from Sequence Orthology
more info
  
involved_in t-circle formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in t-circle formation ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in telomere maintenance via recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via telomere trimming ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Rad51C-XRCC3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rad51C-XRCC3 complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in replication fork ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA repair protein XRCC3
Names
X-ray repair cross-complementing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028875.4 → NP_083151.1  DNA repair protein XRCC3

    See identical proteins and their annotated locations for NP_083151.1

    Status: REVIEWED

    Source sequence(s)
    AC152065
    Consensus CDS
    CCDS26187.1
    UniProtKB/Swiss-Prot
    Q9CXE6
    Related
    ENSMUSP00000021715.6, ENSMUST00000021715.6
    Conserved Domains (1) summary
    cd01123
    Location:82 → 341
    Rad51_DMC1_radA; B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    111769626..111780326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246959.2 → XP_030102819.1  DNA repair protein XRCC3 isoform X1

    UniProtKB/Swiss-Prot
    Q9CXE6
    Conserved Domains (1) summary
    cd01123
    Location:82 → 341
    Rad51_DMC1_radA; B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a similiar ...

  2. XM_006516300.1 → XP_006516363.1  DNA repair protein XRCC3 isoform X2

    Conserved Domains (1) summary
    cl38936
    Location:64 → 270
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXE6.1 GenPept UniProtKB/Swiss-Prot:Q9CXE6

Gene LinkOut

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