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Cxxc1 CXXC finger protein 1 [ Mus musculus (house mouse) ]

Gene ID: 74322, updated on 21-Apr-2024

Summary

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Official Symbol
Cxxc1provided by MGI
Official Full Name
CXXC finger protein 1provided by MGI
Primary source
MGI:MGI:1921572
See related
Ensembl:ENSMUSG00000024560 AllianceGenome:MGI:1921572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cfp1; Cgbp; PHF18; 2410002I16Rik; 5830420C16Rik
Summary
Enables methylated histone binding activity. Predicted to be involved in histone H3-K4 methylation and positive regulation of transcription, DNA-templated. Located in nuclear matrix. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and retina. Orthologous to human CXXC1 (CXXC finger protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 26.1), spleen adult (RPKM 21.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E2; 18 50.7 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (74349283..74354564)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (74216212..74221493)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57658 Neighboring gene STARR-positive B cell enhancer ABC_E1520 Neighboring gene STARR-seq mESC enhancer starr_45003 Neighboring gene spindle and kinetochore associated complex subunit 1 Neighboring gene STARR-seq mESC enhancer starr_45004 Neighboring gene STARR-positive B cell enhancer ABC_E2512 Neighboring gene ribosomal protein L10A pseudogene Neighboring gene methyl-CpG binding domain protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte aging. Wu YW, et al. Nat Commun, 2022 Jun 9. PMID 35680896, Free PMC Article
  2. Role of CxxC-finger protein 1 in establishing mouse oocyte epigenetic landscapes. Sha QQ, et al. Nucleic Acids Res, 2021 Mar 18. PMID 33621320, Free PMC Article
  3. The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation. Kiuchi M, et al. J Exp Med, 2021 Apr 5. PMID 33433611, Free PMC Article
  4. CFP1-dependent histone H3K4 trimethylation in murine oocytes facilitates ovarian follicle recruitment and ovulation in a cell-nonautonomous manner. Sha QQ, et al. Cell Mol Life Sci, 2020 Aug. PMID 31676962
  5. CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes. Sha QQ, et al. Nat Commun, 2018 Aug 28. PMID 30154440, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis.
    Title: CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis.
  2. Expression of the histone lysine methyltransferases SETD1B, SETDB1, SETD2, and CFP1 exhibits significant changes in the oocytes and granulosa cells of aged mouse ovaries.
    Title: Expression of the histone lysine methyltransferases SETD1B, SETDB1, SETD2, and CFP1 exhibits significant changes in the oocytes and granulosa cells of aged mouse ovaries.
  3. Deficiency of CXXC finger protein 1 leads to small changes in heart rate but moderate epigenetic alterations and significant protein downregulation of hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) ion channels in mice.
    Title: Deficiency of CXXC finger protein 1 leads to small changes in heart rate but moderate epigenetic alterations and significant protein downregulation of hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) ion channels in mice.
  4. The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation.
    Title: The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation.
  5. Role of CxxC-finger protein 1 in establishing mouse oocyte epigenetic landscapes.
    Title: Role of CxxC-finger protein 1 in establishing mouse oocyte epigenetic landscapes.
  6. CXXC finger protein 1-mediated histone H3 lysine-4 trimethylation is essential for proper meiotic crossover formation in mice.
    Title: CXXC finger protein 1-mediated histone H3 lysine-4 trimethylation is essential for proper meiotic crossover formation in mice.
  7. A key role for Cfp1 in establishing a complex active promoter chromatin state.
    Title: Cfp1 is required for gene expression-dependent H3K4 trimethylation and H3K9 acetylation in embryonic stem cells.
  8. These data define the Cfp1 PHD domain as a reader of histone H3K4me marks and provide evidence that this activity is involved in the regulation of lineage commitment in ES cells.
    Title: Efficient differentiation of murine embryonic stem cells requires the binding of CXXC finger protein 1 to DNA or methylated histone H3-Lys4.
  9. Oocytes lacking CFP1 failed to complete maturation and were unable to gain developmental competence after fertilization, due to defects in cytoplasmic lattice formation, meiotic division, and maternal-zygotic transition.
    Title: CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes.
  10. Dual inhibition of CFP1 removes the SETD1-CFP1 complex from chromatin and ensures appropriate chromosome configuration changes during meiosis and mitosis.
    Title: CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unmethylated CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set1C/COMPASS complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CXXC-type zinc finger protein 1
Names
CXXC finger 1 (PHD domain)
CpG binding protein
PHD finger and CXXC domain-containing protein 1
cpG-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378844.1 → NP_001365773.1  CXXC-type zinc finger protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC133186
    UniProtKB/TrEMBL
    Q3UIZ4
    Conserved Domains (3) summary
    cd15553
    Location:28 → 73
    PHD_Cfp1; PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)
    pfam02008
    Location:166 → 212
    zf-CXXC; CXXC zinc finger domain
    pfam12269
    Location:410 → 644
    zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

  2. NM_028868.3 → NP_083144.1  CXXC-type zinc finger protein 1 isoform 1

    See identical proteins and their annotated locations for NP_083144.1

    Status: VALIDATED

    Source sequence(s)
    AC133186
    Consensus CDS
    CCDS50320.1
    UniProtKB/Swiss-Prot
    Q9CWW7
    UniProtKB/TrEMBL
    Q3UIZ4, Q541B1
    Related
    ENSMUSP00000025444.7, ENSMUST00000025444.8
    Conserved Domains (3) summary
    pfam02008
    Location:166 → 212
    zf-CXXC; CXXC zinc finger domain
    cd15553
    Location:28 → 73
    PHD_Cfp1; PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)
    pfam12269
    Location:406 → 640
    zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    74349283..74354564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWW7.1 GenPept UniProtKB/Swiss-Prot:Q9CWW7

Gene LinkOut

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