U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Isca2 iron-sulfur cluster assembly 2 [ Mus musculus (house mouse) ]

Gene ID: 74316, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Isca2provided by MGI
Official Full Name
iron-sulfur cluster assembly 2provided by MGI
Primary source
MGI:MGI:1921566
See related
Ensembl:ENSMUSG00000021241 AllianceGenome:MGI:1921566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hbld1; 0710001C05Rik; 5730594E03Rik
Summary
Predicted to enable 2 iron, 2 sulfur cluster binding activity; 4 iron, 4 sulfur cluster binding activity; and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by [4Fe-4S] cluster transfer. Located in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 4. Orthologous to human ISCA2 (iron-sulfur cluster assembly 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 27.8), liver E14.5 (RPKM 25.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
12 D1; 12 39.38 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84820007..84821863)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84773230..84775089)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene synapse differentiation inducing 1 like Neighboring gene STARR-positive B cell enhancer mm9_chr12:86096267-86096568 Neighboring gene NPC intracellular cholesterol transporter 2 Neighboring gene latent transforming growth factor beta binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_32756 Neighboring gene STARR-seq mESC enhancer starr_32757 Neighboring gene RIKEN cDNA D030025P21 gene Neighboring gene STARR-positive B cell enhancer ABC_E7160 Neighboring gene apoptosis resistant E3 ubiquitin protein ligase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86311736-86311923

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ISCA1 is essential for mitochondrial Fe(4)S(4) biogenesis in vivo. Beilschmidt LK, et al. Nat Commun, 2017 May 11. PMID 28492233, Free PMC Article
  2. MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells. He M, et al. Cell Death Dis, 2014 Feb 27. PMID 24577088, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data suggest that cellular processes with different requirements for ISCA1, ISCA2 and ISCA1-ISCA2 complex seem to exist.
    Title: ISCA1 is essential for mitochondrial Fe(4)S(4) biogenesis in vivo.
  2. Data suggest that miR-210 induced repression of ISCU1/2 may contribute to HIF-1alpha-triggered alterations in neuronal energy metabolism after nickel exposure.
    Title: MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein maturation by [4Fe-4S] cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
iron-sulfur cluster assembly 2 homolog, mitochondrial
Names
HESB like domain containing 1
HESB-like domain-containing protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028863.1 → NP_083139.1  iron-sulfur cluster assembly 2 homolog, mitochondrial precursor

    See identical proteins and their annotated locations for NP_083139.1

    Status: VALIDATED

    Source sequence(s)
    AK002936, BY125913, BY577917
    Consensus CDS
    CCDS49111.1
    UniProtKB/Swiss-Prot
    Q9DCB8
    UniProtKB/TrEMBL
    A0A1Y7VK19
    Related
    ENSMUSP00000021667.6, ENSMUST00000021667.7
    Conserved Domains (1) summary
    cl00400
    Location:1 → 153
    Fe-S_biosyn; Iron-sulphur cluster biosynthesis

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84820007..84821863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516297.5 → XP_006516360.1  iron-sulfur cluster assembly 2 homolog, mitochondrial isoform X2

    UniProtKB/TrEMBL
    A0A1Y7VK19
    Conserved Domains (1) summary
    cl00400
    Location:24 → 137
    Fe-S_biosyn; Iron-sulphur cluster biosynthesis

  2. XM_006516298.3 → XP_006516361.1  iron-sulfur cluster assembly 2 homolog, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A1Y7VK19
    Conserved Domains (1) summary
    cl00400
    Location:17 → 130
    Fe-S_biosyn; Iron-sulphur cluster biosynthesis

  3. XM_006516296.4 → XP_006516359.1  iron-sulfur cluster assembly 2 homolog, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VK19
    Related
    ENSMUSP00000152679.2, ENSMUST00000222982.2
    Conserved Domains (1) summary
    cl00400
    Location:33 → 146
    Fe-S_biosyn; Iron-sulphur cluster biosynthesis
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCB8.2 GenPept UniProtKB/Swiss-Prot:Q9DCB8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous