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Spatc1 spermatogenesis and centriole associated 1 [ Mus musculus (house mouse) ]

Gene ID: 74281, updated on 5-Mar-2024

Summary

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Official Symbol
Spatc1provided by MGI
Official Full Name
spermatogenesis and centriole associated 1provided by MGI
Primary source
MGI:MGI:1921531
See related
Ensembl:ENSMUSG00000049653 AllianceGenome:MGI:1921531
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
speriolin; 1700084J23Rik
Summary
Enables gamma-tubulin binding activity. Located in centrosome and cytoplasm. Is expressed in 1-cell stage embryo; germ cell of testis; and spermatozoon. Orthologous to human SPATC1 (spermatogenesis and centriole associated 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 104.4) See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 35.63 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76150731..76176777)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76266531..76292577)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) polymerase family, member 10 Neighboring gene microRNA 6953 Neighboring gene glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) Neighboring gene myocardial infraction associated transcript 2 Neighboring gene microRNA 3079 Neighboring gene sphingomyelin phosphodiesterase 5 Neighboring gene 5-oxoprolinase (ATP-hydrolysing) Neighboring gene STARR-seq mESC enhancer starr_39050 Neighboring gene STARR-positive B cell enhancer ABC_E7384 Neighboring gene exosome component 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Speriolin is a novel human and mouse sperm centrosome protein. Goto M, et al. Hum Reprod, 2010 Aug. PMID 20542897, Free PMC Article
  2. Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20. Goto M, et al. J Biol Chem, 2004 Oct 1. PMID 15280373
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC144830

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables gamma-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
speriolin
Names
spermatogenesis and centriole-associated protein 1
spermatogenic cell-specific Cdc20-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028852.1 → NP_083128.1  speriolin

    See identical proteins and their annotated locations for NP_083128.1

    Status: PROVISIONAL

    Source sequence(s)
    AB032199
    Consensus CDS
    CCDS27564.1
    UniProtKB/Swiss-Prot
    Q148B6, Q14AS6, Q76MV2, Q9D9F0
    UniProtKB/TrEMBL
    A0A0R4J0X4
    Related
    ENSMUSP00000073805.4, ENSMUST00000074173.4
    Conserved Domains (2) summary
    pfam15058
    Location:1 → 262
    Speriolin_N; Speriolin N terminus
    pfam15059
    Location:334 → 480
    Speriolin_C; Speriolin C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76150731..76176777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316766.2 → XP_017172255.1  speriolin isoform X4

    Conserved Domains (2) summary
    pfam15058
    Location:19 → 43
    Speriolin_N; Speriolin N-terminus
    pfam15059
    Location:115 → 261
    Speriolin_C; Speriolin C-terminus

  2. XM_017316762.2 → XP_017172251.1  speriolin isoform X1

    UniProtKB/Swiss-Prot
    Q148B6, Q14AS6, Q76MV2, Q9D9F0
    Conserved Domains (2) summary
    pfam15058
    Location:12 → 212
    Speriolin_N; Speriolin N-terminus
    pfam15059
    Location:284 → 430
    Speriolin_C; Speriolin C-terminus

  3. XM_017316764.3 → XP_017172253.1  speriolin isoform X2

    UniProtKB/Swiss-Prot
    Q148B6, Q14AS6, Q76MV2, Q9D9F0
    Conserved Domains (2) summary
    pfam15058
    Location:1 → 174
    Speriolin_N; Speriolin N-terminus
    pfam15059
    Location:246 → 392
    Speriolin_C; Speriolin C-terminus

  4. XM_017316768.2 → XP_017172257.1  speriolin isoform X5

    UniProtKB/Swiss-Prot
    Q148B6
    Conserved Domains (1) summary
    pfam15059
    Location:38 → 184
    Speriolin_C; Speriolin C-terminus

  5. XM_017316765.2 → XP_017172254.1  speriolin isoform X3

    Conserved Domains (2) summary
    pfam15058
    Location:1 → 125
    Speriolin_N; Speriolin N-terminus
    pfam15059
    Location:165 → 311
    Speriolin_C; Speriolin C-terminus

  6. XM_017316767.2 → XP_017172256.1  speriolin isoform X5

    UniProtKB/Swiss-Prot
    Q148B6
    Conserved Domains (1) summary
    pfam15059
    Location:38 → 184
    Speriolin_C; Speriolin C-terminus

  7. XM_030248802.1 → XP_030104662.1  speriolin isoform X5

    Conserved Domains (1) summary
    pfam15059
    Location:38 → 184
    Speriolin_C; Speriolin C-terminus

  8. XM_017316763.3 → XP_017172252.1  speriolin isoform X2

    UniProtKB/Swiss-Prot
    Q148B6, Q14AS6, Q76MV2, Q9D9F0
    Conserved Domains (2) summary
    pfam15058
    Location:1 → 174
    Speriolin_N; Speriolin N-terminus
    pfam15059
    Location:246 → 392
    Speriolin_C; Speriolin C-terminus

  9. XM_017316769.3 → XP_017172258.1  speriolin isoform X5

    UniProtKB/Swiss-Prot
    Q148B6
    Conserved Domains (1) summary
    pfam15059
    Location:38 → 184
    Speriolin_C; Speriolin C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q148B6.1 GenPept UniProtKB/Swiss-Prot:Q148B6

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