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Usp20 ubiquitin specific peptidase 20 [ Mus musculus (house mouse) ]

Gene ID: 74270, updated on 21-Apr-2024

Summary

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Official Symbol
Usp20provided by MGI
Official Full Name
ubiquitin specific peptidase 20provided by MGI
Primary source
MGI:MGI:1921520
See related
Ensembl:ENSMUSG00000026854 AllianceGenome:MGI:1921520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vdu2; 1700055M05Rik
Summary
Predicted to enable G protein-coupled receptor binding activity; cysteine-type endopeptidase activity; and thiol-dependent deubiquitinase. Predicted to be involved in protein K48-linked deubiquitination; protein K63-linked deubiquitination; and regulation of G protein-coupled receptor signaling pathway. Predicted to act upstream of or within endocytosis and proteolysis. Predicted to be located in centrosome. Predicted to be active in cytoplasm. Is expressed in ganglia; retina; and trigeminal nerve. Orthologous to human USP20 (ubiquitin specific peptidase 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 28.5), genital fat pad adult (RPKM 18.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 B; 2 21.77 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30872291..30912667)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30982279..31022655)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene torsin family 1, member B Neighboring gene torsin family 1, member A (torsin A) Neighboring gene cDNA sequence BC005624 Neighboring gene predicted gene, 39786 Neighboring gene formin binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E9195 Neighboring gene STARR-positive B cell enhancer ABC_E4431 Neighboring gene STARR-seq mESC enhancer starr_04135 Neighboring gene STARR-positive B cell enhancer ABC_E4432 Neighboring gene STARR-positive B cell enhancer ABC_E9196 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:30971715-30971947 Neighboring gene STARR-positive B cell enhancer ABC_E5904 Neighboring gene RIKEN cDNA D330023K18 gene Neighboring gene G protein-coupled receptor 107

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. USP20 links feeding-induced cholesterol synthesis and energy expenditure. Xiao X, et al. Sci China Life Sci, 2021 Feb. PMID 33420925
  2. Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice. Zhang W, et al. Front Endocrinol (Lausanne), 2022. PMID 36636478, Free PMC Article
  3. Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis. Lu XY, et al. Nature, 2020 Dec. PMID 33177714
  4. USP20 Promotes Cellular Antiviral Responses via Deconjugating K48-Linked Ubiquitination of MITA. Zhang MX, et al. J Immunol, 2019 Apr 15. PMID 30814308
  5. Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor. Li Z, et al. Biochem Biophys Res Commun, 2002 Jun 14. PMID 12056827

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis.
    Title: A novel PDIA3/FTO/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis.
  2. Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1beta-evoked signaling in vascular smooth muscle cells and vascular inflammation.
    Title: Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1β-evoked signaling in vascular smooth muscle cells and vascular inflammation.
  3. Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice.
    Title: Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice.
  4. USP20 links feeding-induced cholesterol synthesis and energy expenditure.
    Title: USP20 links feeding-induced cholesterol synthesis and energy expenditure.
  5. Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
    Title: Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
  6. These findings suggest a crucial role of USP20 in maintaining the stability of MITA and promoting innate antiviral signaling.
    Title: USP20 Promotes Cellular Antiviral Responses via Deconjugating K48-Linked Ubiquitination of MITA.
  7. USP20 attenuates TNF- and IL-1beta-evoked atherogenic signaling in smooth muscle cells, by deubiquitinating RIPK1, among other signaling intermediates.
    Title: USP20 (Ubiquitin-Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis.
  8. USP20 regulates beta1AR signaling in vitro and in vivo Additionally, beta1AR-induced USP20 phosphorylation may serve as a feed-forward mechanism to stabilize beta1AR expression and signaling during pathological insults to the myocardium.
    Title: The deubiquitinase ubiquitin-specific protease 20 is a positive modulator of myocardial β(1)-adrenergic receptor expression and signaling.
  9. that pro- and anti-inflammatory activities of beta-arrestin2 are determined by beta-arrestin2 ubiquitination and that changes in USP20 expression and/or activity can therefore regulate inflammatory responses
    Title: Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (8)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 20
Names
VHL-interacting deubiquitinating enzyme 2
deubiquitinating enzyme 20
ubiquitin specific protease 20
ubiquitin thioesterase 20
ubiquitin thiolesterase 20
ubiquitin-specific-processing protease 20
NP_083122.1
XP_030107995.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028846.5 → NP_083122.1  ubiquitin carboxyl-terminal hydrolase 20

    See identical proteins and their annotated locations for NP_083122.1

    Status: VALIDATED

    Source sequence(s)
    AK047242, AK054279, AK173083, BY251374
    Consensus CDS
    CCDS15893.1
    UniProtKB/Swiss-Prot
    Q69ZT5, Q8C6M1, Q8CJ72
    Related
    ENSMUSP00000099913.5, ENSMUST00000102849.11
    Conserved Domains (4) summary
    smart00695
    Location:812 → 896
    DUSP; Domain in ubiquitin-specific proteases
    COG5560
    Location:73 → 688
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    pfam00443
    Location:145 → 684
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:30 → 90
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30872291..30912667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252135.1 → XP_030107995.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X1

    UniProtKB/Swiss-Prot
    Q69ZT5, Q8C6M1, Q8CJ72
    Conserved Domains (4) summary
    smart00695
    Location:812 → 896
    DUSP; Domain in ubiquitin-specific proteases
    COG5560
    Location:73 → 688
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    pfam00443
    Location:145 → 684
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:30 → 90
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C6M1.1 GenPept UniProtKB/Swiss-Prot:Q8C6M1

Gene LinkOut

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