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Gpn1 GPN-loop GTPase 1 [ Mus musculus (house mouse) ]

Gene ID: 74254, updated on 11-Apr-2024

Summary

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Official Symbol
Gpn1provided by MGI
Official Full Name
GPN-loop GTPase 1provided by MGI
Primary source
MGI:MGI:1921504
See related
Ensembl:ENSMUSG00000064037 AllianceGenome:MGI:1921504
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Xab1; MBDIN; NTPBP; 2410004J02Rik
Summary
Predicted to enable GTPase activity. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Is expressed in embryo; sublingual gland primordium; and submandibular gland primordium. Orthologous to human GPN1 (GPN-loop GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.8), CNS E14 (RPKM 10.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gpn1 in Genome Data Viewer
Location:
5 B1; 5 17.27 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31652085..31670250)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31494741..31512904)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12770 Neighboring gene zinc finger protein 512 Neighboring gene STARR-seq mESC enhancer starr_12771 Neighboring gene coiled-coil domain containing 121 Neighboring gene STARR-positive B cell enhancer ABC_E6315 Neighboring gene STARR-seq mESC enhancer starr_12772 Neighboring gene SPT7-like, STAGA complex gamma subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:31829068-31829342 Neighboring gene solute carrier family 4 (anion exchanger), member 1, adaptor protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters. Lembo F, et al. Mol Cell Biol, 2003 Mar. PMID 12588985, Free PMC Article
  2. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GPN-loop GTPase 1
Names
MBD2-interacting protein
XPA binding protein 1
methyl-CpG binding domain protein 2 interacting protein
NP_598517.1
XP_006504224.1
XP_006504225.1
XP_011239076.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133756.6 → NP_598517.1  GPN-loop GTPase 1

    See identical proteins and their annotated locations for NP_598517.1

    Status: VALIDATED

    Source sequence(s)
    AC113276
    Consensus CDS
    CCDS19185.1
    UniProtKB/Swiss-Prot
    Q8VCE2
    UniProtKB/TrEMBL
    Q4VAB2
    Related
    ENSMUSP00000076217.7, ENSMUST00000076949.13
    Conserved Domains (2) summary
    COG1100
    Location:20 → 229
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam03029
    Location:24 → 261
    ATP_bind_1; Conserved hypothetical ATP binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31652085..31670250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504162.3 → XP_006504225.1  GPN-loop GTPase 1 isoform X2

    See identical proteins and their annotated locations for XP_006504225.1

    Conserved Domains (1) summary
    cd17870
    Location:1 → 180
    GPN1; GPN-loop GTPase 1

  2. XM_006504161.5 → XP_006504224.1  GPN-loop GTPase 1 isoform X1

    Conserved Domains (1) summary
    cd17870
    Location:2 → 223
    GPN1; GPN-loop GTPase 1

  3. XM_011240774.4 → XP_011239076.1  GPN-loop GTPase 1 isoform X2

    See identical proteins and their annotated locations for XP_011239076.1

    Conserved Domains (1) summary
    cd17870
    Location:1 → 180
    GPN1; GPN-loop GTPase 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCE2.1 GenPept UniProtKB/Swiss-Prot:Q8VCE2

Gene LinkOut

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