Atg7 autophagy related 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atg7provided by MGI
Official Full Name: autophagy related 7provided by MGI
Primary source: MGI:MGI:1921494
See related: Ensembl:ENSMUSG00000030314 AllianceGenome:MGI:1921494
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Agp7; Apg7l; Atg7l; Gm21553; 1810013K23Rik
Summary: This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 13.1), testis adult (RPKM 12.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 E3

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (114620075..114837565)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (114643127..114860604)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IGF1R stimulates autophagy, enhances viability, and promotes insulin secretion in pancreatic beta cells in gestational diabetes mellitus by upregulating ATG7.
Title: IGF1R stimulates autophagy, enhances viability, and promotes insulin secretion in pancreatic β cells in gestational diabetes mellitus by upregulating ATG7.
ATG7/GAPLINC/IRF3 axis plays a critical role in regulating pathogenesis of influenza A virus.
Title: ATG7/GAPLINC/IRF3 axis plays a critical role in regulating pathogenesis of influenza A virus.
Autophagy gene Atg7 regulates the development of radiation-induced skin injury and fibrosis of skin.
Title: Autophagy gene Atg7 regulates the development of radiation-induced skin injury and fibrosis of skin.
TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
Title: TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
Ablation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppresses Hif1a expression.
Title: Ablation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppresses Hif1a expression.
Endothelial depletion of Atg7 triggers astrocyte-microvascular disassociation at blood-brain barrier.
Title: Endothelial depletion of Atg7 triggers astrocyte-microvascular disassociation at blood-brain barrier.
Thioredoxin 1 promotes autophagy through transnitrosylation of Atg7 during myocardial ischemia.
Title: Thioredoxin 1 promotes autophagy through transnitrosylation of Atg7 during myocardial ischemia.
Acute systemic knockdown of Atg7 is lethal and causes pancreatic destruction in shRNA transgenic mice.
Title: Acute systemic knockdown of Atg7 is lethal and causes pancreatic destruction in shRNA transgenic mice.
MiR-146a-5p accelerates sepsis through dendritic cell activation and glycolysis via targeting ATG7.
Title: MiR-146a-5p accelerates sepsis through dendritic cell activation and glycolysis via targeting ATG7.
ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis.
Title: ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis.

Submit: New GeneRIF Correction See all GeneRIFs (117)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Oda27 (e-PCR), detects polymorphism
- UniSTS:515330

15.MHAa10f3.seq (e-PCR)
- UniSTS:123239

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Atg12 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables Atg12 activating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables Atg12 activating enzyme activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables Atg12 activating enzyme activity	ISO Inferred from Sequence Orthology more info
enables Atg8 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables Atg8 activating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in C-terminal protein lipidation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within autophagy	ISO Inferred from Sequence Orthology more info	PubMed
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hyperoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nitrogen starvation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to reactive oxygen species	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to sodium arsenite	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellar Purkinje cell layer development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaperone-mediated autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular amino acid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular sphingolipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of mucus secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial DNA replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of type B pancreatic cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative stranded viral RNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within organelle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mucus secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein modification process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein modification process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein lipidation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein modification by small protein conjugation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein modification by small protein conjugation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pyramidal neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of type B pancreatic cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axoneme	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in dopaminergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in dopaminergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin-like modifier-activating enzyme ATG7

Names: ATG12-activating enzyme E1 ATG7; autophagy-related protein 7; ubiquitin-activating enzyme E1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001253717.2 → NP_001240646.1 ubiquitin-like modifier-activating enzyme ATG7 isoform 1

See identical proteins and their annotated locations for NP_001240646.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC122843, AC149276, AC170088

Consensus CDS

CCDS59697.1

UniProtKB/TrEMBL

A0A0A0MQN4, Q3TAB9, Q3TM87

Related

ENSMUSP00000133215.4, ENSMUST00000169310.10

Conserved Domains (3) summary

cd01486
Location:396 → 720

Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...

TIGR01381
Location:54 → 740

E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p

pfam16420
Location:52 → 359

ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
NM_001253718.2 → NP_001240647.1 ubiquitin-like modifier-activating enzyme ATG7 isoform 2

See identical proteins and their annotated locations for NP_001240647.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate exon in the 5' coding region, resulting in initiation of translation from a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC122843, AC149276, AC170088

Consensus CDS

CCDS39598.1

UniProtKB/Swiss-Prot

Q3TCD9, Q8K4Q5, Q9D906

UniProtKB/TrEMBL

Q3TAB9, Q3TM87

Related

ENSMUSP00000138137.2, ENSMUST00000182793.8

Conserved Domains (1) summary

TIGR01381
Location:11 → 697

E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
NM_001379130.1 → NP_001366059.1 ubiquitin-like modifier-activating enzyme ATG7 isoform 3

Status: VALIDATED

Source sequence(s)

AC122843, AC149276, AC170088

UniProtKB/TrEMBL

Q3TAB9, Q3TM87

Conserved Domains (1) summary

TIGR01381
Location:27 → 713

E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
NM_028835.5 → NP_083111.1 ubiquitin-like modifier-activating enzyme ATG7 isoform 2

See identical proteins and their annotated locations for NP_083111.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region, resulting in the initiation of translation from a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC122843, AC149276, AC170088

Consensus CDS

CCDS39598.1

UniProtKB/Swiss-Prot

Q3TCD9, Q8K4Q5, Q9D906

UniProtKB/TrEMBL

Q3TAB9, Q3TM87

Related

ENSMUSP00000032457.10, ENSMUST00000032457.17

Conserved Domains (1) summary

TIGR01381
Location:11 → 697

E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p

RNA

NR_166516.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC122843, AC149276, AC170088

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

114620075..114837565

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152367.1 → XP_036008260.1 ubiquitin-like modifier-activating enzyme ATG7 isoform X1

UniProtKB/Swiss-Prot

Q3TCD9, Q8K4Q5, Q9D906

UniProtKB/TrEMBL

Q3TAB9, Q3TM87

Conserved Domains (1) summary

TIGR01381
Location:11 → 697

E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
XM_036152368.1 → XP_036008261.1 ubiquitin-like modifier-activating enzyme ATG7 isoform X1

UniProtKB/Swiss-Prot

Q3TCD9, Q8K4Q5, Q9D906

UniProtKB/TrEMBL

Q3TAB9, Q3TM87

Related

ENSMUSP00000138779.2, ENSMUST00000182428.8

Conserved Domains (1) summary

TIGR01381
Location:11 → 697

E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
XM_036152370.1 → XP_036008263.1 ubiquitin-like modifier-activating enzyme ATG7 isoform X1

UniProtKB/Swiss-Prot

Q3TCD9, Q8K4Q5, Q9D906

UniProtKB/TrEMBL

Q3TAB9, Q3TM87

Conserved Domains (1) summary

TIGR01381
Location:11 → 697

E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
XM_036152369.1 → XP_036008262.1 ubiquitin-like modifier-activating enzyme ATG7 isoform X1

UniProtKB/Swiss-Prot

Q3TCD9, Q8K4Q5, Q9D906

UniProtKB/TrEMBL

Q3TAB9, Q3TM87

Related

ENSMUSP00000138651.2, ENSMUST00000182902.8

Conserved Domains (1) summary

TIGR01381
Location:11 → 697

E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p