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Mterf2 mitochondrial transcription termination factor 2 [ Mus musculus (house mouse) ]

Gene ID: 74238, updated on 5-Mar-2024

Summary

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Official Symbol
Mterf2provided by MGI
Official Full Name
mitochondrial transcription termination factor 2provided by MGI
Primary source
MGI:MGI:1921488
See related
Ensembl:ENSMUSG00000049038 AllianceGenome:MGI:1921488
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mterfd3; 1700007D05Rik
Summary
Predicted to enable DNA binding activity. Predicted to be involved in termination of mitochondrial transcription. Located in mitochondrial nucleoid. Orthologous to human MTERF2 (mitochondrial transcription termination factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 6.7), CNS E14 (RPKM 6.5) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 41.63 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (84951092..84963982, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (85119433..85128027, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27438 Neighboring gene predicted gene, 51826 Neighboring gene transmembrane protein 263 Neighboring gene four and a half LIM domains 4 Neighboring gene STARR-positive B cell enhancer ABC_E722 Neighboring gene cryptochrome circadian regulator 1 Neighboring gene STARR-seq mESC enhancer starr_27439 Neighboring gene STARR-seq mESC enhancer starr_27440 Neighboring gene predicted gene, 38575

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MTERF2 is a nucleoid component in mammalian mitochondria. Pellegrini M, et al. Biochim Biophys Acta, 2009 May. PMID 19366608
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in termination of mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription termination factor 2, mitochondrial
Names
MTERF domain containing 3
mTERF domain-containing protein 3, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379524.1 → NP_001366453.1  transcription termination factor 2, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC122238
    UniProtKB/Swiss-Prot
    Q8BKY8
    Conserved Domains (1) summary
    cl19765
    Location:58 → 360
    mTERF

  2. NM_001379525.1 → NP_001366454.1  transcription termination factor 2, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC122238
    UniProtKB/Swiss-Prot
    Q8BKY8
    Conserved Domains (1) summary
    cl19765
    Location:58 → 360
    mTERF

  3. NM_001379526.1 → NP_001366455.1  transcription termination factor 2, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC122238
    UniProtKB/Swiss-Prot
    Q8BKY8
    Conserved Domains (1) summary
    cl19765
    Location:58 → 360
    mTERF

  4. NM_028832.3 → NP_083108.1  transcription termination factor 2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_083108.1

    Status: VALIDATED

    Source sequence(s)
    AA285696, AC122238, AK047778
    Consensus CDS
    CCDS24088.1
    UniProtKB/Swiss-Prot
    Q8BKY8
    Related
    ENSMUSP00000062762.3, ENSMUST00000050813.4
    Conserved Domains (1) summary
    cl19765
    Location:58 → 360
    mTERF

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    84951092..84963982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245330.2 → XP_030101190.1  transcription termination factor 2, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl19765
    Location:75 → 377
    mTERF
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BKY8.1 GenPept UniProtKB/Swiss-Prot:Q8BKY8

Gene LinkOut

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